Cross-species meta-analysis tool for high throughput genomic and proteomic resear

用于高通量基因组和蛋白质组研究的跨物种荟萃分析工具

• 批准号: 7795072
• 负责人: SAEID AKHTARI
• 金额: $ 48.95万
• 依托单位: NEXTBIO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-10 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795072
• 关键词: Achievement; Adoption; Agriculture; American; Animal Model; Arabidopsis; Award; Biological; Biological Sciences; Biology; Birds; Canis familiaris; Collection; Communities; Data; Databases; Development; Diagnostic; Disease; Ensure; Foundations; Gene Proteins; Genes; Genomics; Human; Imagery; Incentives; Industry; Information Systems; Intention; Knowledge; Letters; Link; Macaca mulatta; Meta-Analysis; Methodology; Methods; Mus; Ontology; Organism; Orthologous Gene; Pathway interactions; Phase; Physiology; Plant Genes; Plant Genome; Plant Physiology; Plants; Positioning Attribute; Primates; Production; Proteins; Proteomics; Rattus; Reporting; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rice; Science; Scientist; Secure; Services; Small Business Innovation Research Grant; Soybeans; Support System; System; Taxonomy; Technology; Tertiary Protein Structure; Translations; Update; Visual; Work; Yeasts; Zebrafish; commercialization; data integration; design; experience; flexibility; fly; indexing; novel; public health relevance; statistics; tool

DESCRIPTION (provided by applicant): We propose to continue the development of our novel application that enables scientists to search and correlate information across studies in different model organisms. NextBio will develop methods that combine the power of genomic and proteomic studies in different organisms to perform exploratory science and generate novel hypothesis. As part of phase II NextBio will incorporate support for additional vertebrate organisms, such as Zebrafish, dog and rhesus monkey. Above organisms, in addition to currently supported human, mouse, rat, fly, worm and yeast will enable a powerful framework for using information from model organisms to better understand human physiology and disease. In addition, NextBio will develop infrastructure to support plant research by incorporating Arabidopsis, corn, rice and soy bean plant genomes into its cross-species framework. This will enable the use of collective knowledge across these species to help agricultural researchers in their research projects. As part of this proposal NextBio will develop gene and protein indexes, as well as translation methodology to link similar sets of genes and proteins from different organisms. Furthermore, it will develop advanced statistical and visualization methods to help correlate and interpret the data. PUBLIC HEALTH RELEVANCE: Project Narrative Large quantities of critical biological information pertaining to human and plant physiology is generated in studies from diverse model organisms. We propose to develop a platform in which researchers can use combined power of these studies to better understand disease development and compound effects on human and plant physiology. This will help scientific community design better diagnostic and treatment options for humans and develop superior agricultural products.

描述（由申请人提供）：我们建议继续开发我们的新应用程序，使科学家能够在不同模式生物的研究中搜索和关联信息。NextBio将开发联合收割机，结合不同生物体的基因组和蛋白质组学研究的力量，进行探索性科学和产生新的假设。作为第二阶段的一部分，NextBio将支持其他脊椎动物生物，如斑马鱼、狗和恒河猴。上述生物，除了目前支持的人类，小鼠，大鼠，苍蝇，蠕虫和酵母将使一个强大的框架，使用来自模型生物的信息，以更好地了解人类的生理和疾病。此外，NextBio将开发基础设施，通过将拟南芥、玉米、水稻和大豆植物基因组纳入其跨物种框架，支持植物研究。这将使跨这些物种的集体知识的使用，以帮助农业研究人员在其研究项目。作为该提案的一部分，NextBio将开发基因和蛋白质索引，以及翻译方法，以连接来自不同生物体的类似基因和蛋白质。此外，它将开发先进的统计和可视化方法，以帮助关联和解释数据。公共卫生关系：项目叙述大量关于人类和植物生理学的重要生物学信息是在对不同模式生物的研究中产生的。我们建议开发一个平台，使研究人员可以利用这些研究的综合力量，更好地了解疾病的发展和对人类和植物生理的复合影响。这将有助于科学界为人类设计更好的诊断和治疗方案，并开发出上级农产品。