The Effect of Aging and Vascular Occlusion on Gait Variability

衰老和血管闭塞对步态变异的影响

• 批准号: 7670722
• 负责人: Sara A Myers
• 金额: $ 2.86万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7670722
• 关键词: Accounting; Address; Affect; Age; Aging; Atherosclerosis; Biological Phenomena; Biological Rhythm; Biomechanics; Biomedical Research; Blood Pressure; Blood Vessels; Blood flow; Brain Ischemia; Buttocks; Cardiovascular Diseases; Cardiovascular system; Clinical; Complex; Data; Development; Diagnosis; Diagnostic; Disease; Elderly; Entropy; Epilepsy; Foundations; Fracture; Functional disorder; Future; Gait; Gender; Health; Heart Rate; Height; Individual; Injury; Intermittent Claudication; Intervention; Ischemia; Joints; Laboratories; Lead; Leg; Link; Lower Extremity; Measures; Mentors; Methods; Morbidity - disease rate; Movement; Muscle Cramp; Muscle function; Nonlinear Dynamics; Outcome; Pain; Pain-Free; Pathology; Patients; Pattern; Peripheral; Peripheral arterial disease; Persons; Physical Function; Physical activity; Physiological; Population; Posture; Procedures; Protocols documentation; Receiver Operating Characteristics; Rehabilitation therapy; Research; Research Personnel; Research Training; Rest; Risk; Rotation; Scientist; Screening procedure; Sensitivity and Specificity; Series; Simulate; Staging; Students; Symptoms; Syndrome; System; Techniques; Therapeutic; Thigh structure; Time; Training; Treatment Effectiveness; Treatment Protocols; United States; Walking; Weight; age effect; age related; biological systems; blood pressure regulation; cost; disability; equilibration disorder; experience; falls; functional disability; gait examination; improved; insight; mortality; motor control; neuromuscular; neuroregulation; older patient; pathological aging; prognostic; research and development; research study; response; sudden cardiac death; tool

DESCRIPTION (provided by applicant): The primary objective is to train the candidate to perform research as a productive, independent investigator in gait function of persons with age related diseases and disabilities. The candidate is pursuing backgrounds in biomechanics and motor control. She is a student at the dissertation research stage of her doctoral training who plans to apply her analytical background to biomedical research questions in clinical populations. The candidate will complete strategically selected coursework and receive intensive research training related with aging and pathological populations. She will enhance her research experience by completing lab rotations in four state-wide laboratories, where she will interact with other scientists. Dr. Nick Stergiou and Dr. Iraklis Pipinos will mentor the candidate's research development and guide her in rigorous research training for the study of gait function in persons with age related diseases and disabilities. The primary objective of this research is to determine the effect of age and restricted blood flow on gait parameters by examining gait variability during walking. The specific mechanisms that contribute to gait dysfunction in peripheral arterial disease (PAD) patients are unclear, despite considerable research efforts. Mobility problems in PAD patients are most commonly attributed to intermittent claudication, however, other manifestations of PAD could be contributing to the problem. Identifying the mechanisms leading to functional problems and determining how much disease is exaggerating the problem is vital to establishing proper screening and treatment protocols for PAD. Methods from nonlinear dynamics, which are being used progressively more in the study of biological phenomena, will be used to analyze and quantify gait variability from joint angle data during walking. Gait variability during normal walking will be compared to walking following induced ischemia in healthy young and older subjects. Data will be subsequently compared to gait variability in PAD patients, who experience ischemia as a result of the disease. We hypothesize that the induced ischemia conditions will lead to altered gait variability in both healthy young and older subjects, and that gait variability will be similar in the induced ischemia condition compared to the natural ischemia experienced by PAD. The proposed research will further our understanding of the effect of blood flow on functional impairments in PAD patients. This information will influence diagnosis procedures and may identify risk of falling in older persons who have PAD but may not experience symptoms. Results of this research will lay the groundwork for future studies evaluating treatment effectiveness and developing rehabilitation protocols to improve physical function and decrease injury risk in older patients.

描述（由申请人提供）：主要目标是培养候选人作为一个富有成效的，独立的研究人员在与年龄相关的疾病和残疾人的步态功能进行研究。候选人正在追求生物力学和运动控制的背景。她是一名学生，在她的博士培训的论文研究阶段谁计划将她的分析背景，以临床人群的生物医学研究问题。候选人将完成战略选择的课程，并接受与老龄化和病理人群相关的强化研究培训。她将通过在四个全州范围的实验室完成实验室轮换，在那里她将与其他科学家互动，以提高她的研究经验。Nick Stergiou博士和Dr. Dr. Dr. Reklis Pipinos将指导候选人的研究开发，并指导她进行严格的研究培训，以研究患有年龄相关疾病和残疾的人的步态功能。本研究的主要目的是通过检查步行过程中的步态变异性来确定年龄和血流受限对步态参数的影响。尽管进行了大量的研究，但导致外周动脉疾病（PAD）患者步态功能障碍的具体机制尚不清楚。PAD患者的活动性问题最常归因于间歇性跛行，然而，PAD的其他表现可能导致该问题。确定导致功能问题的机制，并确定疾病在多大程度上夸大了问题，这对建立适当的PAD筛查和治疗方案至关重要。非线性动力学的方法，这是越来越多地用于生物现象的研究，将被用来分析和量化步态的变化，从关节角度数据在行走。将健康年轻和老年受试者正常行走期间的步态变异性与诱导缺血后行走进行比较。随后将数据与PAD患者的步态变异性进行比较，PAD患者因疾病而发生缺血。我们假设，诱导的缺血条件将导致健康的年轻和老年受试者的步态变异性改变，并且与PAD经历的自然缺血相比，诱导的缺血条件下的步态变异性相似。这项研究将进一步了解血流对PAD患者功能障碍的影响。这些信息将影响诊断程序，并可能确定患有PAD但可能没有症状的老年人的跌倒风险。这项研究的结果将为未来的研究奠定基础，评估治疗效果和制定康复方案，以改善老年患者的身体功能和降低受伤风险。