Addition and Expansion of Laboratory Animal Research Fa*

描述(由申请人提供)： 请求提供支持，通过在现有设施上增加一个四层楼的侧翼，来扩大福克斯·蔡斯癌症中心西楼现有的四层实验动物设施(LAF)。这一新增的25,290平方英尺将增加12,910平方英尺的动物研究净地。超过6000平方英尺的空间用于空气处理设备，以支持合并后的新设施(旧设施加上拟议的新增设施)。这一增加，加上现有设施的翻新(计划在2006-2007年)和增加使用高密度微型隔离笼(已经开始)，将使研究用小鼠的容量增加到25,600只。按照我们目前和预期的使用速度，这一扩展将满足fcc研究人员在2010年前的动物研究需求。 费城目前由中央管理的AAALAC认证计划的能力已被超过，现有设施的大部分过于拥挤，缺乏安全的微生物屏障，使研究面临因感染而无效的风险。拟议的增加将纠正动物空间的不足，并提供高质量的小鼠研究屏障设施，为在严格的微生物安全环境下扩大基因组服务提供空间。它紧挨着现有的设施，将能够利用中央洗碗机和支持服务。它还将为地下室、土拨鼠和鸭子区域增加一个小笼子区域，以更好地将它们与屏障老鼠研究设施分开。这一扩展将提供： -2,032 NSF的检疫空间，用于健康评估和进境小鼠的再衍生。 -4,967 NSF的额外鼠标保管室 -1,078个NSF额外的程序实验室 -额外的笼子清洗和程序区，以支持土拨鼠和鸭子病毒性肝炎研究 -在每个研究用鼠固定区的入口处具有高压灭菌、穿衣和消毒能力 除了上述设施外，扩建部分还将为检疫设施和整个LAF的空气处理设施提供机械空间。园区目前过度开发，因此提供机械支持设备的空间至关重要。因此，冷却塔将设在屋顶上，是支撑LAF的多余冷冻水能力所必需的。屋顶成为冷却塔的主要房地产，以支持这一快速增长的研究综合体。

DESCRIPTION (provided by applicant): Support is requested to expand the existing four-story Laboratory Animal Facility (LAF) in the West Building of the Fox Chase Cancer Center by adding a four-floor wing onto the current facility. This addition of 25,290 gross square feet will add 12,910 net square feet of animal research space. Over 6000 square feet of space is utilized for air handling equipment which supports the combined new facility (old facility plus the proposed addition). This addition, combined with renovation of the existing facility (planned for 2006-2007) and increased use of high density microisolator cages (already begun), will increase the research mouse capacity to 25,600 cages. At our current and expected rate of use this expansion will satisfy the animal research needs of research investigators at FCCC until 2010. Capabilities of the current centrally administered AAALAC accredited program in Philadelphia have been exceeded and much of the existing facility is overcrowded and lacks a secure microbiological barrier, placing studies at risk of being invalidated due to infections. The proposed addition will correct deficiencies in animal space, and provide a high quality mouse research barrier facility with space for expanding genomic services in a setting of stringent microbiological security. Located immediately adjacent to the existing facility, it will be able to utilize central cagewashing and support services. It will also add a small cagewash area for the basement woodchuck and duck area to better separate them from the barrier mouse research facilities. This expansion will provide: -2,032 nsf of quarantine space for the health evaluation and rederivation of incoming mice. -4,967 nsf of additional mouse holding rooms -1,078 nsf of additional procedural laboratories -additional cage washing and procedural areas for support to woodchuck and duck viral hepatitus studies -autoclave, gowning and sterilization capability at the entry to each research mouse holding area In addition to the above, the expansion will house mechanical space for the quarantine facility and air handling for the entire LAF. The campus is currently overdeveloped making available space for mechanical support equipment critical. Therefore, cooling towers will be located on the roof and are necessary for redundant chilled water capacity supporting the LAF. Rooftops become prime real estate for cooling towers to support this rapidly growing research complex.