Conduct of studies to evaluate the toxic potential of N-BUTYLBENZENE SULFONAMIDE (NBBS) in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估正丁基苯磺酰胺 (NBBS) 对实验动物的潜在毒性

• 批准号: 10213569
• 负责人: BARNEY SPARROW
• 金额: $ 80万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2020-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213569
• 关键词: Animals; Chemicals; Data; Data Analyses; Databases; Development; Dose; Evaluation; Goals; Human; Laboratory Animals; National Toxicology Program; Pathology; Phase; Plasticizers; Production; Reporting; Risk; Sulfonamides; Toxic effect; Toxicity Tests; hazard; neurobehavioral; reproductive

The goal of this project is to evaluate the subchronic, reproductive, developmental and neurobehavioral toxicity of NBBS following exposure in dosed feed. These studies are in the pathology/data analysis/reporting phase. There is extensive used of NBBS and its toxicity database is limited. It is a common plasticizer and high production volume chemical. The limited toxicity data suggest multiple targets. The NTP studies will provide valuable data to on a wide variety of endpoints to provide a thorough evaluation of potential hazards. Keywords: toxicity, neurobehavioral, developmental, reproductive, dosed feed, N-BUTYLBENZENE SULFONAMIDE.

本项目的目标是评估NBBS在投喂饲料中暴露后的亚慢性、生殖、发育和神经行为毒性。这些研究处于病理学/数据分析/报告阶段。NBBS应用广泛，但其毒性数据库有限。它是一种常见的增塑剂和高产量化学品。有限的毒性数据表明存在多个靶点。NTP研究将为各种终点提供有价值的数据，以全面评估潜在危害。 关键词：毒性，神经行为，发育，生殖，投喂，N-丁基苯磺酰胺。