Conduct of Studies to Evaluate the Transcriptomic Changes and Toxicologic Potential of Per/Polyfluorinated Alkyl Substances (PFAS) in Laboratory Animals via Gavage

通过灌胃法评估实验动物体内全氟烷基物质/多氟烷基物质 (PFAS) 的转录组变化和毒理学潜力

• 批准号: 10281193
• 负责人: BARNEY SPARROW
• 金额: $ 90.86万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2020-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10281193
• 关键词: Clinical Chemistry; Data; Female; Health; Hepatic; Human; Kidney; Laboratory Animals; Organ Weight; Pathway interactions; Phenotype; Rattus; Risk; Toxicology; base; in vivo; male; primary endpoint; transcriptomics

Selected PFAS with no in vivo toxicology data are being evaluated. The primary endpoints in these studies are hepatic and renal high throughput transcriptomics, in male and female rats exposed for 5 days. Traditional toxicological endpoints (eg organ weights and clinical chemistry) have been added to the studies to provide additional contextualizaing information (i.e., phenotypic anchoring).These data will be used for determining provisional pathway-based transcriptomic BMDs for use in human health risk estimations.

正在评价无体内毒理学数据的选定PFAS。这些研究的主要终点是暴露5天的雄性和雌性大鼠的肝脏和肾脏高通量转录组学。研究中增加了传统毒理学终点（例如器官重量和临床化学），以提供额外的背景信息（即，这些数据将用于确定用于人类健康风险估计的基于临时途径的转录组BMD。