Regulation of blood feeding behavior in the malaria mosquito Anopheles gambiae

疟疾蚊冈比亚按蚊吸血行为的调节

• 批准号: 7535622
• 负责人: Shelli Farhadian
• 金额: $ 4.62万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7535622
• 关键词: Accounting; Address; Africa; Anopheles Genus; Anopheles gambiae; Behavior; Behavioral; Bite; Blood; Candidate Disease Gene; Chemicals; Cues; Culicidae; Development; Disease; Down-Regulation; Drosophila genus; Drosophila melanogaster; Feeding behaviors; Female; Gene Expression; Gene Expression Profiling; Genes; Goals; Hour; Human; In Situ Hybridization; Insect Bites; Insecta; Laboratories; Ligands; Malaria; Mediating; Molecular; Nervous system structure; Neurons; Odorant Receptors; Odors; Otters; Ovarian; Oviposition; Parasites; Perception; Peripheral; Play; RNA; RNA Interference; Receptor Down-Regulation; Receptor Gene; Regulation; Reporting; Role; Sensory; Smell Perception; System; Testing; Time; Transgenic Organisms; Tropical Disease; Work; base; behavior measurement; falls; feeding; in vivo; receptor expression; response; vector

DESCRIPTION (provided by applicant): Olfactory cues guide mosquitoes toward humans, from which the mosquitoes derive the blood they need to complete ovarian development. In the malaria mosquito, Anopheles gambiae, host-seeking is suppressed or inhibited for about 72 hours after the mosquito takes a blood meal. The molecular basis for this behavior remains unknown, but may be explained by a humoral control mechanism in which the sensitivity of the olfactory system is altered following blood-feeding. In this project, I will examine the hypothesis that down-regulation of specific odorant receptors modifies the host-seeking behavior of female Anopheles gambiae after blood-feeding. Many of the world's most devastating tropical diseases are spread by the bite of an insect. One of these insects, the Anopheles mosquito, is responsible for spreading the malaria parasite. By understanding how Anopheles mosquitoes use chemical cues to find humans, it may be possible to limit the spread of diseases such as malaria by controlling the biting behaviors of these insects.

描述（由申请人提供）：嗅觉线索引导蚊子接近人类，蚊子从中获得完成卵巢发育所需的血液。在疟疾蚊子中，冈比亚按蚊，在蚊子吸食血液后约72小时，宿主寻找被抑制或抑制。这种行为的分子基础仍然未知，但可能是由体液控制机制解释的，其中嗅觉系统的敏感性在吸血后改变。在这个项目中，我将检验特定气味受体的下调改变雌性冈比亚按蚊吸血后寻找宿主行为的假设。世界上许多最具破坏性的热带疾病都是通过昆虫叮咬传播的。这些昆虫之一，按蚊，是负责传播疟疾寄生虫。通过了解按蚊如何使用化学线索来寻找人类，通过控制这些昆虫的叮咬行为来限制疟疾等疾病的传播是可能的。