Development of a Total Artificial Lung

全人工肺的研制

• 批准号: 7824820
• 负责人: Robert H. Bartlett
• 金额: $ 2.17万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7824820
• 关键词: Adult; Air Embolism; Animal Model; Animals; Anticoagulation; Award; Biomedical Engineering; Blood; Blood Circulation; Blood flow; Carbon Dioxide; Cardiac; Cardiac Output; Cardiopulmonary; Characteristics; Chronic; Chronic lung disease; Clinical; Clinical Trials; Computer Simulation; Development; Device Designs; Devices; Doctor of Medicine; Doctor of Philosophy; Engineering; Extracorporeal Membrane Oxygenation; Failure; Fiber; Gases; Goals; Grant; Heart Atrium; Heart failure; Heart-Lung Transplantation; Implant; Industry; Laboratories; Life; Liquid substance; Lung; Lung Transplantation; Mechanical ventilation; Mechanics; Membrane; Michigan; Modeling; Nitric Oxide; Operative Surgical Procedures; Organ; Outcome; Patients; Phase; Physiology; Postoperative Period; Pulsatile Flow; Recovery of Function; Rehabilitation therapy; Research; Research Personnel; Resistance; Respiratory Failure; Respiratory physiology; Right Ventricular Function; Series; Sheep; Silicones; Solid; Staging; Surface; Surgeon; System; Techniques; Technology; Testing; Thrombosis; Transplantation; Universities; Waiting Lists; Work; artificial lung; clinical application; cooking; design; electric impedance; experience; hemodynamics; implantation; meetings; programs; prototype; respiratory; ventricular assist device

DESCRIPTION (provided by applicant): Lung transplantation is very successful but limited by availability of donors during the short window between listing and fatal lung failure. This problem is worsened because many potential lung donors are not accepted as borderline lung function might prove fatal in the postoperative period without mechanical support. Extracorporeal Life Support (ECLS) can replace lung function for weeks but is not an appropriate bridge to transplantation. An implantable, total artificial lung (TAL) that could function for 3-6 months would allow more patients to undergo successful lung transplantation, just as the ventricular assist device has been applied to cardiac failure and transplantation. In 2001, we began a ten year project to develop a clinical TAL. We were awarded a bioengineering research partnership (BRP) grant to design and test an implantable total artificial lung (TAL) through the prototype stage. We have completed the goals of that project. Specifically we have developed computer models of device gas exchange and hemodynamics with pulsatile flow to apply to TAL design. We have designed, fabricated, and tested devices, resulting in a prototype (the "Biolung") which meets the specifications for a functional TAL. We developed a servoregulation system to control CO2 clearance by regulating the sweep gas flow. We have routinely implanted the TAL into healthy sheep for 7 days, allowing us to identify the remaining problems which must be solved before clinical trials. These problems are the potential for air embolism, anticoagulation and thrombosis, determining the ideal mode of attachment and TAL blood flow rate, and durability in a 30 day application. With support from renewal of the BRP, we now propose to solve those problems, with the goal of proceeding to clinical trials in five years. Our team of research surgeons, bioengineers, and industry has completed the first half of this project and is ready to bring it to completion. This research team from the University of Michigan includes Robert Bartlett, M.D., a clinician-researcher renowned for his work in ECMO and respiratory failure; Keith Cook, Ph.D., a biomedical engineer with 13 years of experience in the development of total artificial lungs; Jonathan Haft, M.D., a cardiac surgeon with experience in artificial lung testing and clinical heart and lung transplantation; and Ronald Hirschl, M.D., a clinician with 15 years of investigative experience in advanced respiratory support techniques. In addition, Scott Merz, Ph.D., of MC3, Inc., is a biomedical engineer with 16 years experience in the developing artificial lungs and other cardiopulmonary devices.

描述（由申请人提供）：肺移植非常成功，但在列表和致死性肺衰竭之间的短暂窗口期内，供体的可用性受到限制。这个问题变得更加严重，因为许多潜在的肺供体不被接受，因为在没有机械支持的情况下，临界肺功能可能在术后期间被证明是致命的。体外生命支持（ECLS）可以替代肺功能数周，但不是移植的适当桥梁。一种可植入的、可工作3-6个月的全人工肺（TAL）将使更多的患者能够成功进行肺移植，就像心室辅助装置已应用于心力衰竭和移植一样。2001年，我们开始了一个为期十年的项目，以开发临床TAL。我们获得了生物工程研究合作伙伴（BRP）的资助，以设计和测试植入式全人工肺（TAL）的原型阶段。我们已经完成了这个项目的目标。具体而言，我们已经开发了设备气体交换和脉动流的血液动力学的计算机模型，以应用于TAL设计。我们设计、制造和测试了设备，从而产生了符合功能TAL规格的原型（“Biolung”）。我们开发了一种伺服调节系统，通过调节吹扫气体流量来控制CO2清除。我们已经将TAL常规植入健康绵羊体内7天，使我们能够确定在临床试验之前必须解决的剩余问题。这些问题是空气栓塞、抗凝和血栓形成的可能性，确定理想的连接模式和TAL血液流速，以及30天应用的耐久性。在BRP更新的支持下，我们现在建议解决这些问题，目标是在五年内进行临床试验。我们的研究外科医生，生物工程师和行业团队已经完成了这个项目的前半部分，并准备完成它。这个来自密歇根大学的研究小组包括医学博士罗伯特·巴特利特，以ECMO和呼吸衰竭工作而闻名的临床研究员;基思库克博士，生物医学工程师，在全人工肺的开发方面有13年的经验; Jonathan Haft，M.D.，一位在人工肺测试和临床心肺移植方面有经验的心脏外科医生;和罗纳德赫歇尔，医学博士，一位在高级呼吸支持技术方面拥有15年研究经验的临床医生。此外，Scott Merz博士，关于MC 3，Inc是一位生物医学工程师，在开发人工肺和其他心肺设备方面拥有16年的经验。