Research Supplement to Promote Diversity Supplement for the ECMO without Anticoagulation

研究补充促进无抗凝 ECMO 的多样性补充

基本信息

  • 批准号:
    10712181
  • 负责人:
  • 金额:
    $ 4.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Nitric Oxide (NO) is a gaseous radical continuously produced by the endothelial nitric oxide synthase (eNOS) enzyme within the walls of the blood vessels and is an essential molecule to maintain homeostasis and prevent blood clot formation. NO is an extremely reactive molecule with only 2 ms half-life and can form various metabolites in the blood. The artificial surfaces of blood contacting devices can activate platelets and induce thrombus formation. This is a not desired side effect of Extracorporeal Life Support (ECLS) circuits and is typically prevented by systemic anticoagulation, which however increases the risk of hemorrhagic complications. Hence, there is an effort to create more biocompatible artificial surfaces that obviate the need for systemic anticoagulation. NO emitting artificial surfaces offer attractive solution to this problem. However, the NO payload of such surfaces is inherently limited. In this research supplement we would like to explore an alternative approach, where the available NO payload is circulating within the blood in the form of NO metabolites (e.g., nitrite, small and large molecular weight S-nitroso thiols) as reservoirs and is released upon contact with the chemically modified artificial surface of the biomedical device. We would like to achieve this goal through the following aims: Aim 1: Develop analytical methods to measure circulating NO donors in the blood. Selective analytical methods will be developed to quantify potential circulating NO donors (nitrite, small and large molecular weight S-nitroso thiols) in the blood. Aim 2: Modulate concentration of circulating NO reservoirs in the blood. This aim is to assess the effect of the delivered NO gas on the quantity of individual NO metabolites within the blood. NO gas will be delivered to pre-conditioned blood via an in vitro membrane oxygenator setup. This will allow for precise control of the delivery of NO to the blood (partial pressure of NO and O2, flow rate of sweep gas and blood). Aim 3: Modify EC surfaces that can induce NO release from circulating NO reservoirs. We will coat PVC tubing with a polymer coating doped/covalently modified with divalent metal ions (Cu2+) and assess its ability to induce NO release from the circulating NO reservoirs and to prevent blood clot formation in vitro in Chandler loop model.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Robert H. Bartlett其他文献

Extracorporeal Life Support Organization 1993.
体外生命支持组织 1993。
  • DOI:
  • 发表时间:
    1993
  • 期刊:
  • 影响因子:
    0
  • 作者:
    C. J. Stolar;Thomas Delosh;Robert H. Bartlett
  • 通讯作者:
    Robert H. Bartlett
Extracorporeal life support for status asthmaticus.
哮喘持续状态的体外生命支持。
  • DOI:
  • 发表时间:
    1993
  • 期刊:
  • 影响因子:
    9.6
  • 作者:
    Michael B. Shapiro;Andrew C. Kleaveland;Robert H. Bartlett
  • 通讯作者:
    Robert H. Bartlett
Twenty-Four Hour Normothermic Ex Vivo Heart Perfusion With Hemofiltration In an Adult Porcine Model
  • DOI:
    10.1016/j.transproceed.2023.08.014
  • 发表时间:
    2023-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Brianna L. Spencer;Spencer K. Wilhelm;Kristopher A. Urrea;Vikramjit Chakrabortty;Sebastian J. Sewera;Daniel E. Mazur;Robert H. Bartlett;Alvaro Rojas-Peña;Daniel H. Drake
  • 通讯作者:
    Daniel H. Drake
The Artificial Placenta Rescues Premature Lambs from Ventilatory Failure
  • DOI:
    10.1016/j.jamcollsurg.2017.07.354
  • 发表时间:
    2017-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Joseph T. Church;Jennifer S. McLeod;Elena M. Perkins;Robert H. Bartlett;George B. Mychaliska
  • 通讯作者:
    George B. Mychaliska
Development of a membrane oxygenator: overcoming blood diffusiolimitation.
膜氧合器的开发:克服血液扩散限制。
  • DOI:
    10.1016/s0022-5223(19)42526-9
  • 发表时间:
    1969
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Robert H. Bartlett;Diane Kittredge;Bertram S. Noyes;Ralph H. Willard;Philip A. Drinker;Dwight E. Harken
  • 通讯作者:
    Dwight E. Harken

Robert H. Bartlett的其他文献

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{{ truncateString('Robert H. Bartlett', 18)}}的其他基金

ECMO without Anticoagulation
无抗凝的 ECMO
  • 批准号:
    10293106
  • 财政年份:
    2021
  • 资助金额:
    $ 4.32万
  • 项目类别:
Low Cost Electrochemical Gas Phase Nitric Oxide Generator for Biomedical Applications
用于生物医学应用的低成本电化学气相一氧化氮发生器
  • 批准号:
    10026450
  • 财政年份:
    2019
  • 资助金额:
    $ 4.32万
  • 项目类别:
Low Cost Electrochemical Gas Phase Nitric Oxide Generator for Biomedical Applications
用于生物医学应用的低成本电化学气相一氧化氮发生器
  • 批准号:
    10328221
  • 财政年份:
    2019
  • 资助金额:
    $ 4.32万
  • 项目类别:
Electrochemical Generation of Nitric Oxide for Gas Phase Biomedical Applications
用于气相生物医学应用的电化学生成一氧化氮
  • 批准号:
    9243306
  • 财政年份:
    2016
  • 资助金额:
    $ 4.32万
  • 项目类别:
Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest (EROCA) Trial Planning Grant
难治性院外心脏骤停 (EROCA) 体外心肺复苏 (EROCA) 试验计划补助金
  • 批准号:
    9182635
  • 财政年份:
    2016
  • 资助金额:
    $ 4.32万
  • 项目类别:
Bactericidal, Nonthrombogenic Intravascular Catheters
杀菌、不形成血栓的血管内导管
  • 批准号:
    9119055
  • 财政年份:
    2015
  • 资助金额:
    $ 4.32万
  • 项目类别:
Bactericidal, Nonthrombogenic Intravascular Catheters
杀菌、不形成血栓的血管内导管
  • 批准号:
    9316710
  • 财政年份:
    2015
  • 资助金额:
    $ 4.32万
  • 项目类别:
Combined Nitric Oxide Release and Argatroban for Thromboresistant Coatings
结合一氧化氮释放和阿加曲班用于抗血栓涂层
  • 批准号:
    8692758
  • 财政年份:
    2013
  • 资助金额:
    $ 4.32万
  • 项目类别:
Combined Nitric Oxide Release and Argatroban for Thromboresistant Coatings
结合一氧化氮释放和阿加曲班用于抗血栓涂层
  • 批准号:
    8580797
  • 财政年份:
    2013
  • 资助金额:
    $ 4.32万
  • 项目类别:
Mini ECMO Life Support System
迷你ECMO生命支持系统
  • 批准号:
    8453060
  • 财政年份:
    2013
  • 资助金额:
    $ 4.32万
  • 项目类别:

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与血小板反应性相关的各种器官内皮细胞中的碳水化合物分布
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