Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network

婴儿猝死综合症和死产中的产前酒精 (PASS) 网络

• 批准号: 7932581
• 负责人: William P. Fifer
• 金额: $ 116.54万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7932581
• 关键词: Abruptio Placentae; Adverse effects; Affect; Alcohol consumption; Alcohols; Alleles; American Indians; Anxiety; Apoptosis; Arteries; Autopsy; Birth; Blood flow; Brain; Brain Stem; Case Study; Cause of Death; Cerebral cortex; Child health care; Clinical assessments; Collaborations; Color; Communities; Coupling; Data; Development; Developmental Biology; Disease; Dysmorphology; Enrollment; Environmental Risk Factor; Ethanol Metabolism; Exhibits; Experimental Designs; Exposure to; Face; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Development; Fetal Growth Retardation; Fetus; Figs - dietary; Frequencies; Genes; Genetic; Genetic Polymorphism; Genotype; Glutamates; Goals; Head; Heart Rate; Hippocampus (Brain); Histopathology; Human; Impairment; Incidence; Infant; Infant Development; Infant Mortality; Infarction; Injury; Introns; Letters; Life; Life Stress; Link; Maternal Age; Measurement; Measures; Meconium; Methamphetamine; Minisatellite Repeats; Mission; Morbidity - disease rate; Mothers; Movement; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; National Institute of Child Health and Human Development; National Institute on Alcohol Abuse and Alcoholism; Neurologic Manifestations; Neurons; Neurotransmitters; Newborn Infant; Nicotinic Receptors; Nutritional status; Outcome; Pathogenesis; Pathology; Pattern; Perinatal; Physiological; Physiology; Placenta; Placentation; Population; Pregnancy; Pregnancy-Associated Plasma Protein-A; Promoter Regions; Prospective Studies; Recording of previous events; Research; Research Personnel; Respiration; Risk; Role; Scientist; Serotonin; Site; South Africa; Specific qualifier value; Stress; Structure of umbilical artery; Sudden Death; Sudden infant death syndrome; System; Testing; Time; Tobacco use; U-Series Cooperative Agreements; Ultrasonography; Unexplained stillbirth; Vasoactive Intestinal Peptide; alcohol effect; alcohol exposure; alcohol measurement; alpha-Fetoproteins; base; clinical research site; depression; drinking; fetal; heart rate variability; high risk; improved; maternal cigarette smoking; maternal serum; maternal stress; middle cerebral artery; mortality; neurobehavioral; neurochemistry; neurotransmitter uptake; northern plains; offspring; postnatal; premature; prenatal; programs; promoter; receptor expression; response; serotonin transporter; stillbirth

DESCRIPTION (provided by applicant): This application is in response to a Letter of Invitation (LOI-HD-05-111) to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FAS, and to determine how these different outcomes are inter-related. The proposed research will be conducted by the investigators the Prenatal Alcohol, SIDS, and Stillbirth (PASS) Research Network in a cooperative agreement with NICHD and NIAAA. This research involves the collaboration of: 1) two comprehensive clinical sites serving populations that are high risk for prenatal alcohol exposure, SIDS, and stillbirth, i.e. the American Indians in the Northern Plains and the Cape Coloured in Cape Town, South Africa; 2) a central Developmental Biology and Pathology Center (DBPC); 3) a central Data Coordinating and Analysis Center (DCAC); 4) a central Physiology Assessment Center (PAC); and 5) program scientists and officers at the NICHD and NIAAA. This particular application pertains to the Physiology Assessment Center (PAC) of the PASS Network. The experimental design involves a prospective study of 12,000 pregnancies, and two retrospective, autopsy-based studies of SIDS and stillbirth. The long-term goals of the SAFE PASSAGE STUDY are to decrease fetal and infant mortality and improve child health in communities at high risk for prenatal maternal alcohol consumption. The Specific Aims of the Network are as follows: 1. To determine the association between prenatal alcohol exposure and the risk for SIDS and; 2. To determine the role of the timing, pattern, and amount of prenatal alcohol exposure and other environmental factors in the risk for morbidity and mortality in early human life; 3. To determine the role of specific genes in modifying the risk for morbidity and mortality in early life that is associated with prenatal alcohol exposure; 4. To determine the role of alcohol exposure during pregnancy, and interactions among alcohol exposure and environmental and genetic modifiers, in altering profiles of autonomic activity of the fetus and infant, and neurobehavioral outcomes in the infant; 5. To determine the role of maternal alcohol exposure, as influenced by specific environmental and genetic factors, in the impairment of placental function, and thereby the increased risk for fetal and/or infant morbidity and mortality; and 6. To determine abnormalities in key neurotransmitter systems in the brains of fetuses and/or infants that convey risk for sudden death, and to determine the role of prenatal alcohol exposure, as influenced by specific environmental and genetic factors, in their pathogenesis. The mission of the PAC is to conduct sophisticated analyses of physiologic control based on the recordings obtained from subjects enrolled in the SAFE PASSAGE STUDY.

描述（由申请人提供）：本申请是对邀请函（LOI-HD-05-111）的回应，该邀请函旨在开展与社区相关的研究，调查产前酒精暴露在小岛屿发展中国家、死胎和FAS风险中的作用，并确定这些不同结果之间的相互关系。拟议的研究将由产前酒精、小岛屿发展中国家和死产研究网络（PASS）的研究人员与NICHD和NIAAA达成合作协议进行。本研究涉及以下合作：1)两个综合性临床站点，服务于产前酒精暴露、小岛屿发展中国家和死产的高风险人群，即北部平原的美洲印第安人和南非开普敦的开普有色人种；2)中央发育生物学和病理学中心（DBPC）；3)中央数据协调与分析中心（DCAC）；4)中央生理评估中心（PAC）；5) NICHD和NIAAA的项目科学家和官员。这个特殊的应用程序属于PASS网络的生理评估中心（PAC）。实验设计包括对12,000例妊娠的前瞻性研究，以及对SIDS和死产的两项回顾性尸检研究。