Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network

婴儿猝死综合症和死产中的产前酒精 (PASS) 网络

• 批准号: 8701599
• 负责人: William P. Fifer
• 金额: $ 2.21万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8701599
• 关键词: Affect; Alcohol consumption; Alcohols; Anxiety; Autopsy; Biological Neural Networks; Brain; Brain Stem; Cerebral cortex; Child; Child health care; Clinical; Cognitive; Communities; Complex; Data; Data Analyses; Data Collection; Data Coordinating Center; Development; Developmental Biology; Early Intervention; Electroencephalography; Enrollment; Environmental Risk Factor; Face; Failure; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Death; Fetal Development; Fetal Growth; Fetal Ultrasonography; Fetus; Forensic Medicine; Functional disorder; Genetic; Goals; Growth; Hearing; Infant; Infant Development; Investigation; Knowledge; Life; Link; Maternal Age; Measures; Mediating; Medical; Mental Depression; Mission; National Institute of Child Health and Human Development; National Institute on Alcohol Abuse and Alcoholism; Neurotransmitters; Outcome; Participant; Pathologic; Pathology; Pattern; Performance; Perfusion; Perinatal; Phase; Physiological; Physiology; Placenta; Pregnancy; Pregnancy Outcome; Public Health; Reporting; Request for Applications; Research; Research Infrastructure; Risk; Role; Scientist; Site; Stress; Structure; Sudden infant death syndrome; Synapses; Testing; Time; Ultrasonography; Variant; Work; adverse outcome; aging nutrition; base; clinical research site; critical period; fetal; fetal tobacco exposure; follow-up; high risk; improved; in vivo; infant death; interest; neurobehavioral; northern plains; prenatal; prevent; programs; resilience; response; stillbirth; tobacco exposure

The goal of the PASS Network is to determine the role of prenatal alcohol exposure in the risk for the sudden infant death syndrome (SIDS) and adverse outcomes of pregnancy, particularly stillbirth and fetal alcohol spectrum disorders (FASD), and in the potential inter-relationships between SIDS, stillbirth, and FASD. This application is in response to the Request for Application (RFA-HD-10-018) entitled "Role of Prenatal Alcohol Exposure in SIDS and Stillbirth". As requested, it proposes the completion of enrollment and follow-up of study participants and the performance of data analysis in Phase II of the PASS Network by the current five clinical, physiologic, biologic/pathologic, and data coordinating centers. The mission of the network is to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FAS, and to determine how these different outcomes are inter-related. The PASS Network is a collaborative effort comprised of two Comprehensive Clinical Sites (CCS) - Northern Plains Comprehensive Clinical Site (NPCCS) and Stellenbosch Comprehensive Clinical Site (SCCS), a Developmental Biology and Pathology Center (DBPC), a Physiology Assessment Center (PAC), and a centralized Data Coordinating and Analysis Center (DCAC) and program scientists and officers at the NICHD and NIAAA. This particular application pertains to the Physiology Assessment Center (PAC) of the PASS Network. The role of the PAC is to oversee the data collection infrastructure and analyze the physiological data from the 12,000 subjects tested at the PASS Network Clinical Sites. These early assessments will define physiological consequences of prenatal alcohol and other exposures prior to the development of adverse outcomes. The potential impact of this work is that, in combination with pathological, environmental and genetic findings, we will be better able to define the mechanisms that underlie vulnerability to stillbirth SIDS and FASD. The information gained will provide the potential for prospectively identifying fetuses and infants at greatest risk and the possibility for more precise targeting of early interventions.

PASS 网络的目标是确定产前酒精暴露在婴儿猝死综合症 (SIDS) 和妊娠不良结局（特别是死产和胎儿酒精谱系障碍 (FASD)）风险中的作用，以及 SIDS、死产和 FASD 之间潜在的相互关系。本申请是对题为“产前酒精暴露在 SIDS 和死产中的作用”的申请请求 (RFA-HD-10-018) 的回应。根据要求，它建议由当前五个临床、生理、生物/病理和数据协调中心完成研究参与者的入组和随访以及 PASS 网络第二阶段的数据分析。该网络的使命是开展社区相关研究，调查产前酒精暴露在婴儿猝死综合症、死产和胎儿酒精综合症风险中的作用，并确定这些不同结果之间的相互关系。 PASS 网络是由两个综合临床中心 (CCS) - 北部平原综合临床中心 (NPCCS) 和斯泰伦博斯综合临床中心 (SCCS)、发育生物学和病理学中心 (DBPC)、生理学评估中心 (PAC) 和集中数据协调和分析中心 (DCAC) 以及 NICHD 和 NICHD 的项目科学家和官员组成的协作项目。 NIAAA。此特定应用程序属于 PASS 网络的生理学评估中心 (PAC)。 PAC 的作用是监督数据收集基础设施并分析 PASS 网络临床站点测试的 12,000 名受试者的生理数据。这些早期评估将在出现不良后果之前确定产前酒精和其他暴露的生理后果。这项工作的潜在影响是，结合病理、环境和遗传发现，我们将能够更好地确定死产 SIDS 和 FASD 脆弱性的机制。获得的信息将有可能前瞻性地识别风险最大的胎儿和婴儿，并有可能更精确地进行早期干预。