Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
基本信息
- 批准号:7905316
- 负责人:
- 金额:$ 17.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAmoxicillinApplications GrantsBloodCessation of lifeChildhoodChronicClavulanateClinicalClinical DataCollectionConsensusCoupledData QualityDatabasesDelawareDetectionDevelopmentDiseaseFundingGrantHealth PersonnelHealth systemHealthcare SystemsHepaticHepatologyInjuryInternetLiverMaintenanceMarylandNew JerseyPatientsPennsylvaniaPharmaceutical PreparationsPharmacogeneticsPharmacogenomicsPharmacologic SubstancePhenytoinPhiladelphiaPopulation HeterogeneityProviderQuality of lifeReportingResearch PersonnelResolutionResourcesSamplingSpecimenSymptomsSystemTissuesUnited States National Institutes of HealthUniversitiesUrineValproic AcidWorkbasecase-basedinterestisoniazidliver transplantationmemberprospectiverepositorysocioeconomicsweb site
项目摘要
The Drug Induced Liver Injury Network (DILIN), funded by the National Institutes of Health in 2002,
represents a critical strategy to mitigate the adverse consequences of DILI. Already, this extensive network
of centers around the U.S. has cultivated an impressive repertoire of case-based clinical information and
samples which will broaden our understanding of DILI. Initial work centered around retrospectivedata
collection on DILI attributable to four drugs; amoxicillin/clavulanate, valproic acid, phenytoin, and isoniazid.
Subsequent work, which is ongoing, involves the prospective accrual of incident cases of DILI from any drug
or complementary and alternative medication. The purpose of this grant application is to contribute to the
expansion of the DILIN through the participation of a large Philadelphia-based consortium; the Jefferson and
University of Pennsylvania Health Systems represent the largest and second largest health care systems in
the region, respectively. They draw adult and pediatric patients with hepatic disease from the region
comprising Eastern Pennsylvania, Delaware, Southern and Central New Jersey, and Northern Maryland.
Hepatology leaders from these health care systems have agreed to collaborate as a single clinical center for
this grant. In addition, the Geisinger Health System will participate as a subsite of Jefferson; this component
will extend the consortium's reach to include a large part of central Pennsylvania. The consortium will bring
to DILIN a large ethnically and socioeconomically diverse population of patients. The specific aims of this
proposal are as follows: 1) To identify bona fide adult and pediatric cases of DILI within the region
comprising Eastern and Central Pennsylvania, Maryland, Delaware,and Southern and Central NewJersey;
2) To validate the accuracy of disease attribution, in conjunction with other members of DILIN; 3) To support
a national network of centers devoted to the advancement of pharmacogenetic and
pharmacoepidemiological study of DILI, by providing clinical information and samples; and 4) 4. To
participate in the development and maintenance of a website for use as an educational resource on DILI.
RELEVANCE (Seeinstructions): '
This large network of clinical centers interested in identifying and recording cases of drug induced liver injury
will provide unique observations on pharmacoepidemiology.the clinical manifestations,and the
consequences of such inury. It will help create a unique data base and repository of samplesfor any
subsequent pharmacogenomic analysis.
2002年由美国国立卫生研究院资助的药物性肝损伤网络(DILIN)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('VICTOR J NAVARRO', 18)}}的其他基金
Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
- 批准号:
8029391 - 财政年份:2010
- 资助金额:
$ 17.81万 - 项目类别:
Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
- 批准号:
8330956 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Prospective Surveillance Drug and HDS-Induced Liver Injury
药物和 HDS 引起的肝损伤的前瞻性监测
- 批准号:
9132249 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Prospective Surveillance Drug and HDS-Induced Liver Injury
药物和 HDS 引起的肝损伤的前瞻性监测
- 批准号:
8627315 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Prospective Surveillance Drug and HDS-Induced Liver Injury
药物和 HDS 引起的肝损伤的前瞻性监测
- 批准号:
8729480 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
- 批准号:
8132963 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
- 批准号:
7693777 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
- 批准号:
7928727 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
- 批准号:
7595298 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
Continuation and Expansion of the Drug Induced Liver Injury Network(PHILLY-DILIN)
药物性肝损伤网络的延续和扩展(PHILLY-DILIN)
- 批准号:
8625650 - 财政年份:2008
- 资助金额:
$ 17.81万 - 项目类别:
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