Trajectories of Urologic Disease: Follow-up of BACH

波士顿地区社区卫生(BACH)研究正在填补在流行性感冒流行病学方面的知识空白 泌尿系统问题--尤其是不同种族/民族、性别、年龄和性别的患病率和危险因素的差异。 社会经济地位。随机抽样5,506名成年人(3,205名女性，2,301名男性；1,770名 (黑人，1,877名西班牙裔，1,859名白人)被成功招募(2002-2005年)。两个小时的面谈 获得有关泌尿系统症状、社会人口统计学、测量的人体测量学、健康状况的信息 和药物使用(处方药和非处方药)、生活方式和心理社会因素以及保健 利用率。从大多数(70%)受试者身上获得静脉血样(20mis)。论文主题 由科学咨询委员会确定并确定优先事项：43张海报和摘要已被 在国家和国际会议上提交；发表/接受了6篇同行审议的论文；13 已提交并正在审查中；8个正在积极制定中；已确定59个主题供今后的文件使用。 我们建议将巴赫从横截面设计转变为前瞻性队列设计：努力保持在 与受试者接触，最近(2006)非常成功地尝试重新采访500名受试者(在4+ (n=4.130)表明，80%以上(n=4.130)可以重新征聘。特征性好的患者的前瞻性随访 主题提供了一个机会来解决有关泌尿系统症状流行病学的问题： 同一主题内的自然病史(进展/缓解)，与主要慢性疾病的纵向关系 疾病，药物流行病学，生活经历/事件的作用，寻求帮助的行为，以及正式和 非正式费用(烦恼、痛苦和生活质量)。它将提供亟需的发病率，以及 有机会测试基线关联的稳健性，并帮助解开病理生理途径。 面试将继续面对面进行(通常使用相同的基线面试者)，以避免 由于数据收集模式不同而产生的差异。对基线数据的分析为许多小说提供了依据 纵向问题。 巴赫的独特特征包括：？以社区为基础的随机样本：？包括种族/民族 少数群体；有足够数量的男性和女性：30-80岁的广泛年龄段：其重点 关于症状(而不是定义不清的情况)；？使用经过验证的现场仪器：？其多学科 定位：其代表性和普适性：生物标本的现成；以及 努力保持与所有巴赫主题的当前联系。 这项研究将检验“泌尿系统冰山”--人群中泌尿系统症状的发生率、风险 因素，随时间变化，对生活质量的影响，卫生保健的使用，以及新出现的负担 暗示有泌尿系统疾病的症状。

The Boston Area Community Health (BACH) study is filling knowledge gaps in the epidemiology of urologic problems - especially variations in prevalence and risk factors by race/ethnicity, gender, age, and socioeconomic status. A random population sample of 5,506 adults (3,205 females, 2,301 males; 1,770 Black, 1,877 Hispanic, 1,859 White) was successfully recruited (2002-2005). A 2-hour in-person interview obtained information on urologic symptoms, sociodemographics, measured anthropometries, health status and pharmaceutical usage (both prescribed and OTC), lifestyles and psychosocial factors, and health care utilization. A venous blood sample (20 mis) was obtained from a majority (70%) of subjects. Paper topics were identified and prioritized by a Scientific Advisory Committee: 43 posters and abstracts have been presented at national and international meetings; 6 peer-reviewed papers have appeared/been accepted; 13 submitted and under review; 8 are in active development; 59 topics have been identified for future papers. We propose to transition BACH from a cross-sectional to a prospective cohort design: efforts to remain in contact with subjects and a recent (2006) highly successful attempt to re-interview 500 subjects (after 4+ years) show that over 80% (n=4.130) can be re-recruited. Prospective follow-up of well-characterized subjects provides an opportunity to address questions concerning the epidemiology of urological symptoms: natural history (progression/remission) within the same subject, longitudinal relationship with major chronic diseases, pharmacoepidemiology, the role of life experiences/events, help-seeking behavior, and formal and informal costs (bother, distress and quality of life). It will provide much needed incidence rates, an opportunity to test the robustness of baseline associations, and help unravel pathophysiologic pathways. Interviews will continue to be conducted in-person (often using the same baseline interviewer) to avoid variations due to different data gathering modes. Analyses of the baseline data have informed many novel longitudinal questions. Unique features of BACH include: ¿ a random community-based sample: ¿ inclusion of race/ethnic minorities; ¿ sufficient numbers of both males and females: ¿ the broad age-span of 30-80 years: ¿ its focus on symptoms (rather than ill-defined conditions); ¿ use of validated field instruments: ¿ its multidisciplinarv orientation: ¿ its representativeness and generalizabilitv: ¿ the ready availability of biologic specimens: and the efforts to remain in current contact with all BACH subjects. This study will examine the "urologic iceberg" - the incidence of urologic symptoms in the population, risk factors, changes over time, impact on quality of life, use of health care, and the emerging burden of symptoms suggestive of urologic disease.