Modeling Immunity for Biodefense

生物防御免疫建模

• 批准号: 8078296
• 金额: $ 161.94万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078296
• 关键词: Antigens; Biological Models; Categories; Dendritic Cells; Disease; Equilibrium; Foundations; Goals; Human; Immune; Immune response; Immunity; In Vitro; Infection; Influenza; Interferons; Knowledge; Laboratories; Mediating; Modeling; National Institute of Allergy and Infectious Disease; Newcastle disease virus; PTPN11 gene; Pathway interactions; Research Design; Signal Pathway; Signal Transduction; Simulate; Vaccinia; Viral; Viral Antigens; Viral Proteins; Virus Diseases; base; biodefense; immune function; improved; in vivo; mathematical model; model development; novel; pathogen; programs; research study; vector

The program, Modeling Immunity for Biodefense, will develop novel or improved highly predictive mathematical models that simulate immune function. These model systems will be developed for analysis of host immune responses to NIAID category A-C pathogens, and may apply to other infectious and immune-mediated diseases. Knowledge gained from these studies will: advance our understanding of the delicate balance required to induce protective immunity; guide laboratory experiments of host immune responses; and lay the foundation for development of models that can extrapolate human immune responses to infection or immune-mediated diseases based on results from relevant in vitro and in vivo studies.

该计划，生物防御免疫建模，将开发新的或改进的高度预测的数学模型，模拟免疫功能。这些模型系统将被开发用于分析宿主对NIAID A-C类病原体的免疫反应，并可能适用于其他传染病和免疫介导的疾病。从这些研究中获得的知识将：促进我们对诱导保护性免疫所需的微妙平衡的理解;指导宿主免疫反应的实验室实验;并为开发模型奠定基础，该模型可以根据相关的体外和体内研究结果推断人类对感染或免疫介导的疾病的免疫反应。