FUNCTIONAL PROMISCUITY IN O-SUCCINYLBENZOATE SYNTHASE
FUNCTIONAL PROMISCUITY IN O-SUCCINYLBENZOATE SYNTHASE
批准号:
8170521
负责人:
PATRICIA CLEMENT BABBITT
金额:
$0.7万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-07-01 至 2011-06-30
关键词:
AcidsAffectCatalysisChimera organismComputer Retrieval of Information on Scientific Projects DatabaseComputer softwareDatabasesEnzymesEvolutionFamilyFundingGCG geneGoalsGrantInstitutionMediatingMutagenesisMutationPhylogenetic AnalysisReactionResearchResearch PersonnelResourcesSourceStructureUnited States National Institutes of Healthbasedesignenolasememberprotein structureracemization
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The goal of this project is to determine the structural basis of catalytic promiscuity in the enzyme o-Succinylbenzoate synthase (OSBS), a member of the enolase superfamily. Members of the OSBS family can share as little as 15% identity, and the only conserved residues in the family are also conserved in other members of the enolase superfamily which catalyze different reactions. This suggests that although OSBS function has been maintained during the course of evolution, the residues and structures that determine this function have evolved divergently and are not conserved. We are determining the structural basis for OSBS catalysis by using structural comparisons to rationally design mutations that are predicted to affect OSBS activity. In addition, many members of one branch of the OSBS family catalyze a second reaction, N-succinylamino acid racemization (NSAR). We are performing structural, phylogenetic, and mutagenesis studies to determine how some members of the OSBS family can catalyze the NSAR reaction while others cannot. This project will utilize several RBVI resources, including Chimera, the Structure Function Linkage Database, and software available through RBVI such as GCG and MrBayes. Comparing structures, function and evolution of the OSBS family will add to our understanding about the functional plasticity of proteins and how structure mediates function.
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THE STRUCTURE-FUNCTION LINKAGE DATABASE
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批准号:8363588
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项目类别:
-
资助金额:$2.79万
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财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
LAYING THE FOUNDATIONS FOR GENOMIC ENZYMOLOGY
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批准号:8363593
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项目类别:
-
资助金额:$1.68万
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财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ACTIVE SITE SIGNATURES FOR SFLD: ENOLASE SUPERFAMILY
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批准号:8363627
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项目类别:
-
资助金额:$1.68万
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财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ACTIVE SITE SIGNATURES FOR AUTOMATIC UPDATES OF SFLD SUPERFAMILIES
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批准号:8363621
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项目类别:
-
资助金额:$1.68万
-
财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ENZYME ACTIVE SITE TEMPLATES
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批准号:8363587
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项目类别:
-
资助金额:$1.68万
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财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
A COMPUTATIONAL ATLAS OF THE T BRUCEI DEGRADOME AS A GUIDE TO DRUG DISCOVERY
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批准号:8363620
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项目类别:
-
资助金额:$1.68万
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财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ACTIVE SITE SIGNATURES FOR SFLD: KINASE SUPERFAMILY
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批准号:8363628
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项目类别:
-
资助金额:$1.68万
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财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ENZYME FUNCTION INITIAVE
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批准号:8363638
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项目类别:
-
资助金额:$1.68万
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财政年份:2011
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负责人:PATRICIA CLEMENT BABBITT
-
依托单位:
ENZYME ACTIVE SITE TEMPLATES
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批准号:8170507
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项目类别:
-
资助金额:$1.79万
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财政年份:2010
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ACTIVE SITE SIGNATURES FOR SFLD: ENOLASE SUPERFAMILY
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批准号:8170567
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项目类别:
-
资助金额:$1.79万
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财政年份:2010
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负责人:PATRICIA CLEMENT BABBITT
-
依托单位:
ROADMAP FOR DRUG DISCOVERY IN SMALL MOLECULE METABOLISM
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批准号:8170555
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项目类别:
-
资助金额:$1.79万
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财政年份:2010
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
IGTC (PGA) TRAINING AND OUTREACH
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批准号:8170549
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项目类别:
-
资助金额:$1.89万
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财政年份:2010
-
负责人:PATRICIA CLEMENT BABBITT
-
依托单位:
LAYING THE FOUNDATIONS FOR GENOMIC ENZYMOLOGY
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批准号:8170514
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项目类别:
-
资助金额:$1.79万
-
财政年份:2010
-
负责人:PATRICIA CLEMENT BABBITT
-
依托单位:
THE STRUCTURE-FUNCTION LINKAGE DATABASE
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批准号:8170509
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项目类别:
-
资助金额:$2.66万
-
财政年份:2010
-
负责人:PATRICIA CLEMENT BABBITT
-
依托单位:
ACTIVE SITE SIGNATURES FOR AUTOMATIC UPDATES OF SFLD SUPERFAMILIES
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批准号:8170559
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项目类别:
-
资助金额:$1.79万
-
财政年份:2010
-
负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ACTIVE SITE SIGNATURES FOR SFLD: KINASE SUPERFAMILY
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批准号:8170568
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项目类别:
-
资助金额:$1.79万
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财政年份:2010
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
CYTOSCAPE AND BIOLOGICAL CONTEXT OUTREACH AND TRAINING
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批准号:8170550
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项目类别:
-
资助金额:$1.89万
-
财政年份:2010
-
负责人:PATRICIA CLEMENT BABBITT
-
依托单位:
A COMPUTATIONAL ATLAS OF THE T BRUCEI DEGRADOME AS A GUIDE TO DRUG DISCOVERY
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批准号:8170558
-
项目类别:
-
资助金额:$1.79万
-
财政年份:2010
-
负责人:PATRICIA CLEMENT BABBITT
-
依托单位:
THE STRUCTURE-FUNCTION LINKAGE DATABASE
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批准号:7955474
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项目类别:
-
资助金额:$5.03万
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财政年份:2009
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
ACTIVE SITE SIGNATURES FOR AUTOMATIC UPDATES OF SFLD SUPERFAMILIES
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批准号:7955530
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项目类别:
-
资助金额:$2.38万
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财政年份:2009
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负责人:PATRICIA CLEMENT BABBITT
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依托单位:
海外基金