Epidemiology of Cancer in a Cohort of Older Women

老年女性群体的癌症流行病学

• 批准号: 7887847
• 负责人: Kimberly Z Robien
• 金额: $ 47.1万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7887847
• 关键词: Address; Age; American; Ancillary Study; Area; Body fat; Cancer Survivor; Cancer Survivorship; Censuses; Cessation of life; Characteristics; Cohort Studies; Colorectal Cancer; Communities; Comorbidity; Data; Data Collection; Data Set; Data Sources; Diet; Dietary Factors; Disease; Division of Cancer Control and Population Sciences; Dysmyelopoietic Syndromes; Elderly; Elderly woman; Endometrial Carcinoma; Epidemiology; Female; Funding; Future Generations; Genetic Research; Healthcare; Incidence; Individual; Intervention; Investigation; Iowa; Life; Life Style; Link; Mails; Malignant Neoplasms; Malignant neoplasm of thyroid; Medical Surveillance; Modeling; Molecular Epidemiology; National Cancer Institute; Outcome; Paraffin Embedding; Participant; Pattern; Peer Review; Physical environment; Postmenopause; Prospective Studies; Public Health; Publications; Publishing; Quality of life; Questionnaires; Registries; Reporting; Research; Research Design; Resources; Retrieval; Risk; Risk Factors; Rural Developments; SEER Program; Site; Social Characteristics; Source; Surveys; Time; Tissues; United States Centers for Medicare and Medicaid Services; United States Dept. of Health and Human Services; Universities; Woman; Women' s Health; aged; base; cancer diagnosis; cancer epidemiology; cancer prevention; cancer risk; cohort; cost; diet and cancer; experience; follow-up; improved; indexing; interest; leukemia; malignant breast neoplasm; mortality; neoplasm registry; older women; population health; programs; prospective; public health relevance; social; survivorship

DESCRIPTION (provided by applicant): The Iowa Women's Health Study (IWHS) began in 1986 as a longitudinal cohort study to determine whether diet, body fat distribution, and other risk factors were related to cancer incidence among 41,836 post- menopausal women aged 55-69 years. Exposure and lifestyle information was collected in a baseline mailed survey in 1986, and five follow-up surveys in 1987, 1989, 1992, 1997 and 2004. Cancer incidence and mortality have been obtained by annual linkage with the Iowa Cancer Registry (a SEER cancer registry) and the National Death Index since 1986. The project has been extremely productive, with more than 260 research publications published to date. We propose, in this 5-year renewal, to continue to address important questions related to cancer in older women. The cohort is becoming especially informative with regard to less common cancers, and for lifestyle predictors of cancer occurrence and survival among the elderly. We also propose new linkages to sources of community-level data that will allow us to study how an individual's social and physical environment influences their cancer risk. These data sources include the Area Resource File (US Department of Health and Human Services), US Census Data, and data from the Rural Development Initiative Study based at Iowa State University. Our specific aims for the proposed funding period are to: 1) continue to follow the IWHS cohort, who are now 78-92 years old, through a total of 27 years (1986-2012), 2) expand our ongoing investigations of risk factors for incident cancers among women, 3) determine the factors associated with quality of life and mortality among female cancer survivors, and 4) determine the associations between community-level social and environmental characteristics and cancer outcomes and quality of life among elderly women. Continuation of funding for the IWHS is vital not only to completion of the research described in the specific aims, but is also key to supporting existing and several planned ancillary studies. The IWHS is also an active participant in several consortia of cohort studies. The combination of the extensive exposure and follow-up data already collected, linkage with community-level data that will be obtained at no cost, a productive research team, and the important research questions that are proposed make a 5-year continuation of the IWHS an extremely cost-effective means towards improving public health. PUBLIC HEALTH RELEVANCE: With the increasing number of Americans over the age of 65 years, prevention of cancer and its impact in later life is taking on greater importance. Research findings from the Iowa Women's Health Study will continue to add to our understanding of the potentially modifiable factors contributing to cancer prevention and survivorship, and will help public health and health care practitioners prioritize and better utilize health care resources.

描述（由申请人提供）：爱荷华州妇女健康研究（IWH）始于1986年，是一项纵向队列研究，旨在确定饮食，体内脂肪分布和其他危险因素是否与55-69岁的绝经后妇女之间的41,836名妇女之间的发生率是否与癌症发生率有关。在1986年的一项基线邮寄调查中收集了曝光和生活方式信息，1987年，1989年，1989年，1992年，1997年和2004年进行了五次随访调查。通过与爱荷华州癌症登记局（A SEER癌症登记局）的年度联系，已获得癌症的发病率和死亡率，自1986年以来，该项目自1986年以来。该项目与260年的研究出版物相比，该项目非常生产。我们建议在这个五年的续约中继续解决与老年妇女癌症有关的重要问题。对于较不常见的癌症，以及老年人之间癌症发生和生存的生活方式预测因素，该队列变得特别有用。我们还提出了与社区级数据来源的新联系，这将使我们能够研究个人的社会和身体环境如何影响其癌症风险。这些数据来源包括区域资源文件（美国卫生与公共服务部），美国人口普查数据以及位于爱荷华州立大学的农村发展计划研究中的数据。我们对拟议资助期的具体目的是：1）继续遵循IWH的同伴，他们现在已经78-92岁了，总计27岁（1986-2012）（1986-2012），2）扩大我们对妇女的危险因素的持续调查的持续调查，3）与环境之间的质量和环境之间的质量和4）确定了与环境的质量，并确定了与环境的质量，并确定了与环境之间的质量，并确定了癌症的质量，并确定了癌症的质量，并确定了癌症的质量，并确定了癌症的质量，并确定了癌症的质量，并确定了4）。老年妇女的生活。继续为IWH提供资金不仅对完成特定目的所述的研究至关重要，而且还是支持现有和几项计划的辅助研究的关键。 IWH也是几个队列研究财团的积极参与者。已经收集了广泛的曝光和随访数据的结合，与社区级别的数据联系在一起，这些数据将免费获得，一名富有成效的研究团队以及提出的重要研究问题，使IWH的5年延续为5年延续了一项非常具有成本效益的手段，以改善公共卫生。 公共卫生相关性：随着65岁以上的美国人数量的增加，预防癌症及其对以后的生活的影响变得更加重要。爱荷华州妇女健康研究的研究结果将继续增加我们对有助于预防癌症和生存的潜在可修改因素的理解，并将帮助公共卫生和卫生保健从业人员确定优先级，并更好地利用医疗保健资源。