A new non-invasive technology to diagnose preterm labor

诊断早产的新型非侵入性技术

• 批准号: 7944038
• 负责人: Curtis L Lowery
• 金额: $ 47.06万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944038
• 关键词: Abdomen; Accounting; Action Potentials; Anogenital region; Birth; Cells; Cervical; Clinical; Data; Development; Devices; Diagnosis; Early Diagnosis; Emotional; Environment; Family; Fetal Development; Fetal Research; Fetus; Financial cost; Fundus; Hospitals; Hour; Human; Impairment; Incidence; Individual; Infant; Investigation; Knowledge; Labor Onset; Lead; Length; Location; Magnetism; Measurement; Measures; Medicine; Membrane; Methodology; Methods; Morbidity - disease rate; Mothers; Myometrial; Neonatal Intensive Care; Nervous System Physiology; Newborn Infant; Outcome; Patients; Perinatal; Physiological; Physiology; Predictive Value; Pregnancy; Premature Birth; Premature Infant; Premature Labor; Premature Rupture Fetal Membranes; Process; Published Comment; Resolution; Respiratory System; Risk Factors; Rupture; Smooth Muscle; Squid; System; Technology; Testing; Therapeutic Intervention; Time; Ultrasonography; United States; Uterine Contraction; Uterine Monitoring; Uterus; base; design; fetal fibronectin; high risk; innovation; insight; instrument; magnetic field; medical complication; mortality; premature; prevent; public health relevance; reproductive; sensor; uterine smooth muscle cell

DESCRIPTION (provided by applicant): Premature delivery accounts for 12% of all births in the United States and is identified as the leading cause of perinatal morbidity and mortality. Despite advancements in medicine and technology, the incidence of preterm birth has not decreased in recent years and knowledge of the physiological mechanism of the onset and propagation of uterine contractions of preterm labor remains incomplete. Current uterine monitoring methodologies have low positive predictive values and lack the sensitivity to study and plan appropriate therapeutic interventions. We propose to use a non-invasive technology device called SARA (Squid Array for Reproductive Assessment) to study the physiological mechanism of uterine contractions by non-invasively recording magnetic fields (Magnetomyography-MMG) corresponding to electrical activity of the uterine smooth muscle. SARA was designed to cover the entire maternal abdomen with 151 individual sensors. By simultaneously recording uterine MMG from multiple points, we gain access to spatial-temporal information unattainable prior to SARA. Its location within the labor and delivery unit provides unique access to preterm patients. The array design provides non-invasive magnetic recording of the initiation and propagation of uterine electrical activity resulting from excitation and propagation of action potentials in uterine smooth muscle cells. The detailed spatial-temporal resolution of SARA can determine regions of localized activation, propagation velocity and direction, and spread of activity as a function of distance. This data will be used to define physiological steps leading to organized uterine contractions, thus providing the basis for the development of a methodology to accurately predict the onset of active labor. New insight into the initiation and propagation of uterine electrophysiological activity may also provide innovative approaches toward suppression of preterm labor and induction of labor. The specific aims of the proposed project are: 1. Determine if serial uterine MMG measurements can be used to predict the onset of labor in patients with prolonged premature rupture of membranes. 2. Determine if uterine MMG recordings can be used to discern false preterm labor from true preterm labor. In addition, we plan to compare the predictive power of MMG to standards tests for pre-term labor. PUBLIC HEALTH RELEVANCE:A new non-invasive technology to better diagnosis of preterm labor which can lead to development of strategies that can prevent or control preterm labor thereby reducing the incidence of preterm birth.

描述（由申请人提供）：早产占美国所有出生的12%，并被确定为围产期发病率和死亡率的主要原因。尽管医学和技术的进步，早产的发生率并没有减少，在最近几年和知识的发病和传播的子宫收缩早产的生理机制仍然是不完整的。目前的子宫监测方法具有较低的阳性预测值，并且缺乏研究和计划适当治疗干预的敏感性。我们建议使用一种称为SARA（Squid Array for Reproductive Assessment）的非侵入性技术设备，通过非侵入性记录与子宫平滑肌电活动相对应的磁场（Magnetomyography-MMG）来研究子宫收缩的生理机制。SARA设计用于覆盖整个孕妇腹部，有151个单独的传感器。通过同时从多个点记录子宫MMG，我们获得了SARA之前无法获得的时空信息。它在分娩和分娩单位内的位置为早产患者提供了独特的通道。该阵列设计提供了对子宫平滑肌细胞中动作电位的激发和传播引起的子宫电活动的启动和传播的非侵入性磁记录。详细的空间-时间分辨率的SARA可以确定区域的局部激活，传播速度和方向，以及作为距离的函数活动的蔓延。这些数据将用于定义导致有组织子宫收缩的生理步骤，从而为开发准确预测活跃分娩开始的方法提供基础。对子宫电生理活动的启动和传播的新认识也可能为抑制早产和引产提供创新的方法。拟议项目的具体目标是：1。确定连续子宫MMG测量是否可用于预测长期胎膜早破患者的分娩开始。2.确定子宫MMG记录是否可用于区分假早产和真早产。此外，我们计划将MMG的预测能力与早产的标准测试进行比较。 公共卫生相关性：一种新的非侵入性技术，可以更好地诊断早产，从而制定预防或控制早产的策略，从而降低早产的发生率。