Chromosome Metabolism and Cancer

描述(由申请人提供)：本申请寻求在NOT-OD-09-058通知的支持下，为另外两名博士后研究员提供资金，“NIH宣布恢复法案资金可用于竞争性修订申请”。我们已经确定了两名称职的学员和杰出的导师，他们将被添加到当前奖项的培训计划中，该奖项将于2011年3月31日结束。增加这些受训者将扩大研究和培训的范围，包括关于调节人类细胞核内染色体位置的机制的研究，以及关于microRNA如何调节癌细胞中基因表达的研究。这两个项目都与癌症高度相关，两位候选人都非常合格。重要的是，其中一名受训人员是代表不足的少数群体。如果得到资助，这项奖励将通过为两名受训人员提供就业机会来实现恢复法的目标，为期约18个月(取决于奖励开始日期)，并将帮助这些杰出的候选人在癌症生物学和染色体新陈代谢领域的职业生涯中前进。 相关性：授予所要求的补充资金将允许立即资助两名优秀的、合格的受训人员，并为国家的癌症研究工作提供持久的投资。

DESCRIPTION (provided by applicant): This application seeks funding for two additional postdoctoral research fellows under the aegis of Notice NOT-OD-09-058, "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications". We have identified two worthy trainees and outstanding mentors who would be added to the Training Program for the duration of the current award, which ends 03/31/2011. Adding these trainees would expand the scope of the research and training to include studies on mechanisms that regulate chromosome location within the human cell nucleus and research on how microRNA's regulate gene expression in cancer cells. Both projects are highly cancer relevant, and both candidates are very highly qualified. Importantly, one of the trainees is an under-represented minority. If funded, this award would achieve the goals of the Recovery Act by providing employment to two trainees, for approximately 18 months (depending on the award start date), and would help these outstanding candidates forward in their careers in cancer biology and chromosome metabolism. RELEVANCE: Award of the requested supplement would allow the immediate funding of two excellent, qualified trainees and provide a lasting investment in the Nation's cancer research effort.