Chromosome Metabolism and Cancer

描述（由申请人提供）： 本申请旨在根据通知NOT-OD-09-058“NIH宣布恢复法案资金用于竞争性修订申请”的支持，为另外两名博士后研究员提供资金。我们已经确定了两名有价值的学员和优秀的导师，他们将在2011年3月31日结束的当前奖项期间加入培训计划。增加这些受训人员将扩大研究和培训的范围，包括对人类细胞核内染色体定位调节机制的研究，以及对microRNA如何调节癌细胞基因表达的研究。这两个项目都与癌症高度相关，两位候选人都非常合格。重要的是，其中一名受训人员是代表性不足的少数民族。如果获得资助，该奖项将通过为两名受训人员提供约18个月的就业机会来实现《恢复法》的目标（取决于奖项的开始日期），并将帮助这些杰出的候选人在癌症生物学和染色体代谢方面的职业生涯中取得进展。 相关性：授予所要求的补充将允许立即资助两名优秀的合格学员，并为国家的癌症研究工作提供持久的投资。

DESCRIPTION (provided by applicant): This application seeks funding for two additional postdoctoral research fellows under the aegis of Notice NOT-OD-09-058, "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications". We have identified two worthy trainees and outstanding mentors who would be added to the Training Program for the duration of the current award, which ends 03/31/2011. Adding these trainees would expand the scope of the research and training to include studies on mechanisms that regulate chromosome location within the human cell nucleus and research on how microRNA's regulate gene expression in cancer cells. Both projects are highly cancer relevant, and both candidates are very highly qualified. Importantly, one of the trainees is an under-represented minority. If funded, this award would achieve the goals of the Recovery Act by providing employment to two trainees, for approximately 18 months (depending on the award start date), and would help these outstanding candidates forward in their careers in cancer biology and chromosome metabolism. RELEVANCE: Award of the requested supplement would allow the immediate funding of two excellent, qualified trainees and provide a lasting investment in the Nation's cancer research effort.