Chromosome Metabolism and Cancer

描述（由申请人提供）：本申请在通知 NOT-OD-09-058“NIH 宣布为竞争性修订申请提供恢复法案资金”的支持下寻求为另外两名博士后研究员提供资金。我们已经确定了两名有价值的学员和杰出导师，他们将在当前奖励期间（截至 2011 年 3 月 31 日结束）加入培训计划。增加这些学员将扩大研究和培训的范围，包括对调节人类细胞核内染色体位置的机制的研究以及对 microRNA 如何调节癌细胞中基因表达的研究。这两个项目都与癌症高度相关，而且两位候选人都非常合格。重要的是，其中一名受训者是少数族裔。如果获得资助，该奖项将为两名受训者提供约 18 个月的就业机会（取决于奖项开始日期），从而实现《康复法案》的目标，并将帮助这些杰出候选人在癌症生物学和染色体代谢领域的职业生涯中取得进步。 相关性：所要求的补助金的授予将允许立即资助两名优秀、合格的学员，并为国家的癌症研究工作提供持久的投资。

DESCRIPTION (provided by applicant): This application seeks funding for two additional postdoctoral research fellows under the aegis of Notice NOT-OD-09-058, "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications". We have identified two worthy trainees and outstanding mentors who would be added to the Training Program for the duration of the current award, which ends 03/31/2011. Adding these trainees would expand the scope of the research and training to include studies on mechanisms that regulate chromosome location within the human cell nucleus and research on how microRNA's regulate gene expression in cancer cells. Both projects are highly cancer relevant, and both candidates are very highly qualified. Importantly, one of the trainees is an under-represented minority. If funded, this award would achieve the goals of the Recovery Act by providing employment to two trainees, for approximately 18 months (depending on the award start date), and would help these outstanding candidates forward in their careers in cancer biology and chromosome metabolism. RELEVANCE: Award of the requested supplement would allow the immediate funding of two excellent, qualified trainees and provide a lasting investment in the Nation's cancer research effort.