Stressful Life Events, Genetic Variants and Obesity in Chinese Adolescents

描述（由申请人提供）：随着中国经济的快速发展和社会文化的变化，肥胖和压力，特别是学业压力和家庭冲突，在中国青少年中已成为日益严重的公共卫生问题。由于紧张的生活事件或日常麻烦引起的慢性压力与肥胖的病因学有关，这是通过多巴胺和5-羟色胺参与情绪调节导致能量平衡的破坏。一些调节多巴胺和5-羟色胺合成、释放、摄取和转运的候选基因已被确定与肥胖和体重指数（BMI）相关，在有限但不断增长的文献中发现了混合结果。针对NIDDK计划宣布的肥胖、糖尿病、消化和肾脏疾病的二次分析，（PA-09-131），我们建议对现有的遗传和环境数据进行二次分析，以调查压力生活事件、遗传变异及其相互作用对抑郁症状、食物消耗、体力活动和不活动的影响，和肥胖在中国武汉的中国青少年的代表性样本。我们打算（1）描述一系列压力性生活事件对四个领域的影响（学校、家庭、同伴和个人）对抑郁症状体验、食物消耗、身体活动和不活动以及超重和肥胖状况的影响;（2）系统地研究调节大脑5-羟色胺和多巴胺系统的特定候选基因对抑郁症状、饮食、（3）探讨X基因应激事件对抑郁症状、进食、体力活动与超重和肥胖表型的交互作用;以及（4）探索性别的其他潜在调节作用，家庭和谐和社会支持的感知可用性与压力事件和抑郁症状，饮食，体育活动和超重和肥胖表型的特定基因。 公共卫生相关性：随着我国经济的快速发展和社会文化的变迁，肥胖和压力，尤其是学业压力和家庭矛盾已成为我国青少年日益严重的公共卫生问题。这项拟议的研究将推进我们对基因和压力生活事件对青少年肥胖和相关行为的联合和交互作用的认识，对改善青少年的身体发育和心理健康具有重要的公共卫生意义。

DESCRIPTION (provided by applicant): As China undergoes rapid economic development nd sociocultural change both obesity and stress, especially academic stress and family conflicts, among Chinese adolescents have become an increasing public health problem. Chronic stress due to stressful life events or daily hassles has been linked to the etiology of obesity through involvement of dopamine and serotonin for mood regulation leading to the disruption of energy balance. A few candidate genes regulating dopamine and serotonin synthesis, release, uptake and transportation have been identified to be associated with obesity and body mass index (BMI) with mixed findings in a limited but growing body of literature. In response to the NIDDK program announcement of Secondary Analysis in Obesity, Diabetes and Digestive and Kidney Diseases (PA-09-131), we propose to conduct a secondary analysis with existing genetic and environmental data to investigate effects of stressful life events, genetic variants and their interactions on depressive symptoms, food consumption, physical activity and inactivity, and obesity in a representative sample of Chinese adolescents living in Wuhan, China. We intend to (1) delineate effects of a battery of stressful life events assessed on four domains (school, family, peer and individual) on depressive symptom experience, food consumption, physical activity and inactivity, and overweight and obesity status; (2) systematically examine the potential impacts of specific candidate genes regulating brain serotonin and dopamine systems on depressive symptoms, eating, physical activity and overweight and obesity phenotypes; (3) investigate gene X stressful events interactions on depressive symptoms, eating, physical activity and overweight and obesity phenotypes; and (4) explore other potential moderating effects of gender, family harmony and perceived availability of social support with stressful events and specific genes on depressive symptoms, eating, physical activity and overweight and obesity phenotypes. PUBLIC HEALTH RELEVANCE: As China undergoes rapid economic development and ociocultural change both obesity and stress, especially academic stress and family conflicts among Chinese adolescents have become an increasing public health problem. The proposed study will advance our knowledge of the joint and interactive effects of genes and stressful life events on obesity and related behaviors among adolescents, with important public health implications for improving the physical development and mental well-being of adolescents.