Training Program in Quantitative Biology and Physiology

描述（由申请人提供）：本提案寻求五年以上的支持，以继续我们新成立的培训计划，题为定量生物学和生理学（QBP）。我们的使命是培养博士。研究科学家，他们有：（1）对分子生物学、细胞生物学和生理学的基本原理有定量的理解;（2）将现代方法与生物学和生理学相结合的能力;（3）将基于机械的建模技能与生物和物理系统相结合的能力，以及（4）通过系统或过程的多个层次（分子-细胞-组织-器官）的整合来评估涌现行为的能力。我们更新的具体目标是： * 维持一个跨学科的导师队伍，导师来自生物医学工程，生物学，物理学，化学，数学，制造工程，电气与计算机工程和机械工程。 * 提供一个程序课程，包括在定量分子生物学，细胞生物学和生理学包括严格的培训：分子和遗传系统，细胞到组织系统，组织到器官/感觉系统，尺度独立的分析和建模，和多尺度测量技术。 * 提供实验室轮换，确保接触到与生物学和生理学多尺度问题相关的定量和系统/动力学研究技术。 * 为研究生提供机会进行论文研究，是跨学科的，定量的，综合的，并必须与实验数据。 * 通过互动组件建立QBP计划的独特身份和影响，包括期刊俱乐部，年度QBP研讨会，学生教师科学课程务虚会和每月晚餐。 我们的第一个培训赠款周期是成功的。我们正在吸引高素质的学员谁组织创造一个授权的身份。这些学员解决非常具有挑战性的问题，从生物材料，神经生物学，基因组工程和系统生物学等领域的综合生物力学，这些学员还保持促进QBP计划的主题，以丰富整个机构的活动。我们扩大了我们的培训导师库，提高了整个部门的质量，并根据经验和反馈成熟了我们的管理方法。我们期待有机会在下一个赠款周期继续保持这一势头。

DESCRIPTION (provided by applicant): This proposal seeks five more years of support to continue our newly established training program entitled Quantitative Biology and Physiology (QBP). Our mission is to train Ph.D. research scientists who have: (1) a quantitatively-based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the capacity to synthesize modern methods with biology and physiology; (3) the capacity to synthesize mechanistic based modeling skills with biological and physical systems, and (4) the capacity to assess emergent behavior via integration across multiple levels (molecular-cellular-tissue-organ) of a system or process. The specific objectives of our renewal are: * To maintain an interdisciplinary faculty of mentors from Biomedical Engineering, Biology, Physics, Chemistry, Mathematics, Manufacturing Engineering, Electrical & Computer Engineering and Mechanical Engineering. * To provide a program curriculum that includes rigorous training in quantitative molecular biology, cell biology, and physiology inclusive of: Molecular and Genetic Systems, Cellular-to-Tissue Systems, Tissue-to-Organ/Sensory Systems, Scale-Independent Analysis and Modeling, and Multi-Scale Measurement Techniques. * To provide lab rotations that ensure exposure to quantitative and systems/dynamics research techniques relevant to problems at multiple scales of biology and physiology. * To provide graduate trainees with the opportunity to conduct thesis research that is interdisciplinary, quantitative, integrative, and necessarily linked to experimental data. * To establish a unique identity and impact of the QBP program via interactive components, including a Journal Club, Yearly QBP Symposium, Student-Faculty Science-Curriculum Retreats, and Monthly Dinners. Our first training grant cycle was successful. We are attracting high caliber trainees who have organized to create an empowering identity. These trainees address very challenging problems in areas ranging from biomaterials to neurobiology to genomic engineering and systems biology to integrated biomechanics, etc. These trainees also sustain activities that foster the themes of the QBP program so as to enrich the entire institution. We expanded our training mentor pool, improved the quality of the department as a whole, and matured our administrative approach based on experience and feedback. We look forward to the opportunity to continue this momentum during our next grant cycle.