Familial Female Sexual Orientation Phenotypes

家族性女性性取向表型

• 批准号: 7774285
• 负责人: Alan R Sanders
• 金额: $ 30.5万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-05 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7774285
• 关键词: Address; Adult; Affect; Alleles; Attention; Basic Science; Behavior; Behavioral; Biocompatible Materials; Biology; Bisexual; Brain; Brothers; Characteristics; Childhood; Chromosome Mapping; Communities; Complement; Complex; DNA; Data; Databases; Development; Diabetes Mellitus; Employee Strikes; Etiology; Event; Exploratory/Developmental Grant; Family; Family Study; Family history of; Family member; Feeling; Female; Festival; Funding; Future; Gays; Gender; Genes; Genetic; Genome; Goals; Handedness; Heterosexuals; Homosexuality; Homosexuals; Human; Individual; Journals; Knowledge; Learning; Lesbian; Life; Literature; Methods; Mind; Minority; Molecular; Molecular Genetics; Paper; Patient Self-Report; Phenotype; Population; Principal Investigator; Psychology; Publishing; Questionnaires; Relative (related person); Reporting; Saliva; Sample Size; Sampling; Scanning; Science; Second Degree Relative; Sex Behavior; Sex Orientation; Sexual Development; Sexuality; Siblings; Site; Societies; Twin Studies; Variant; Work; Xq28; case control; fluidity; genome wide association study; genotyping technology; indexing; informant; interest; male; non-genetic; population based; prevent; proband; public health relevance; sex; trait; willingness

DESCRIPTION (provided by principal investigator): This application consists of one site, complemented by three consultants, for the application "Familial Female Sexual Orientation Phenotypes" under the R21 mechanism. The long-term goal is to better understand genetic contributions to the trait of sexual orientation, one of the most important variations in human behavior, both in the realms of psychology and biology. Because sexuality is an essential part of human life, it is important to understand normal human sexual development, including sexual orientation. Female sexual orientation is strikingly different in some aspects, and understudied compared to male sexual orientation. This includes both pre-molecular approaches (e.g., family and twin studies) and especially in molecular approaches (i.e., genetic mapping). This R21 will address this knowledge gap by means of a family study to explore the relationship between female sexual orientation and associated phenotypes (fluidity, gender nonconformity, and handedness). This will guide further work with molecular approaches, especially a genome-wide association study (GWAS) that will be the focus of an ensuing R01 application. The current R21 study specific aims are: (A) to determine the most familial female sexual orientation phenotype. In a family study (N = 2,000) the following will be assessed: female sexual orientation, fluidity (i.e., fluctuation in aspects of sexual orientation), gender nonconformity, and handedness of probands (index family members) versus sexual orientation in the probands' female relatives; (B) to conduct the first family study of female sexual fluidity by comparing rates of fluidity in probands with fluidity in the probands' female relatives (by proband report, i.e., the family history method); and (C) to collect proband saliva-derived DNA samples as pilot data/biomaterials for an R01 application for a population-based case-control GWAS. Recruitment will include both 1,000 probands from Gay Pride festivals and 1,000 probands from general community festivals, resulting in ~1,000 lesbian or bisexual and ~1,000 heterosexual female probands. These probands complete questionnaires about their sexual orientation, fluidity, gender nonconformity, and handedness. The will also provide information on sexual orientation and fluidity of their female first- and second-degree relatives (expecting about 9 such relatives per proband). On a subset of ~500 probands, questionnaire data will also be collected directly from their relatives by means of the same anonymous questionnaire online to validate the information obtained by the family history method. Preliminary analyses suggest that for the proposed sample size, these aims can be achieved with high statistical power. PUBLIC HEALTH RELEVANCE: Contributions to the development of sexual orientation, one the most important variations in human behavior, are largely unknown, though more extensively studied in males compared to females. Because sexuality is an essential part of human life - for individuals and society - it is important to understand normal human sexual development, including sexual orientation. Furthermore, factual information about sexuality can help prevent distorted and hostile views.

描述（由主要研究者提供）：本申请由一个研究中心组成，由三名顾问补充，用于R21机制下的"家族性女性性取向表型"申请。长期目标是更好地了解遗传对性取向特征的贡献，这是人类行为中最重要的变化之一，无论是在心理学还是生物学领域。由于性是人类生活的重要组成部分，因此了解正常的人类性发育（包括性取向）非常重要。女性性取向在某些方面与男性性取向有着显著的不同，并且与男性性取向相比研究不足。这包括前分子方法（例如，家庭和双胞胎研究）并且尤其是在分子方法中（即，遗传作图）。这个R21将通过家庭研究来解决这个知识差距，以探索女性性取向和相关表型（流动性，性别不一致性和惯用手）之间的关系。这将指导分子方法的进一步工作，特别是全基因组关联研究（GWAS），这将是随后R01应用的重点。目前R21研究的具体目标是：（A）确定最具家族性的女性性取向表型。在一项家庭研究（N = 2,000）中，将评估以下内容：女性性取向、流动性（即，性取向方面的波动）、性别不一致性和先证者的惯用手（索引家族成员）与先证者的女性亲属的性取向;（B）通过比较先证者的性流动率与先证者的女性亲属的性流动率（根据先证者报告，即，家族史方法）;以及（C）收集先证者唾液来源的DNA样品作为R01应用的试点数据/生物材料，用于基于人群的病例对照GWAS。招募将包括来自同性恋骄傲节的1,000名先证者和来自一般社区节日的1,000名先证者，导致约1,000名女同性恋或双性恋者和约1,000名异性恋女性先证者。这些先证者完成了关于他们的性取向、流动性、性别不一致性和惯用手的问卷。他们还将提供有关其女性一级和二级亲属的性取向和流动性的信息（预计每个先证者约有9名此类亲属）。在约500名先证者的一个子集上，还将通过相同的匿名问卷在线直接从其亲属收集问卷数据，以验证通过家族史方法获得的信息。初步分析表明，对于拟议的样本量，这些目标可以实现高统计功效。 公共卫生关系：性取向是人类行为中最重要的变化之一，对性取向发展的贡献在很大程度上是未知的，尽管与女性相比，男性的研究更为广泛。由于性是人类生活的重要组成部分-对个人和社会-重要的是要了解正常的人类性发展，包括性取向。此外，关于性行为的事实信息有助于防止扭曲和敌对的观点。