Developing Implantable Miniature Temperature Sensors for Cryosurgery Control

开发用于冷冻手术控制的植入式微型温度传感器

• 批准号: 7787703
• 负责人: YOED RABIN
• 金额: $ 23.3万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7787703
• 关键词: Biological; Brachytherapy; Brachytherapy Seeds; Cancerous; Cereals; Characteristics; Clinical; Communication; Computer Systems Development; Coupling; Cryosurgery; Custom; Data; Development; Devices; Electronics; Elements; Equilibrium; Evaluation; Feedback; Foundations; Freezing; Frequencies; Goals; Heating; High temperature of physical object; Image; Imaging Device; Imaging Techniques; Implant; Incineration; Individual; Interdisciplinary Study; Lasers; Link; Location; Magnetism; Measurement; Measures; Medical; Medicine; Methods; Miniaturization; Modality; Modeling; Monitor; Nature; Operative Surgical Procedures; Organ; Outcome; Outcome Study; Output; Phase; Procedures; Process; Prostate; Radiation; Radio; Radiofrequency Interstitial Ablation; Reading; Regulation; Research; Rice; Risk; Seeds; Sensory; Silicon; Staging; Sum; Surgeon; System; Techniques; Technology; Temperature; Temperature Sense; Testing; Time; Tissues; Translating; Ultrasonography; Urethra; Wireless Technology; base; design; experience; follow-up; improved; innovation; magnetic field; minimally invasive; model development; nanoparticle; operation; programs; prototype; public health relevance; reconstruction; sensor; simulation; success; tumor

DESCRIPTION (provided by applicant): The development of wireless implantable temperature sensors is proposed, for the purpose of evaluation and control of thermal surgery. Thermal surgery, or the thermal destruction of undesired biological tissues- such as cancerous tumors-can be achieved by either freezing (also known as cryosurgery), or by heating, with the examples of high frequency ultrasound (HIFU), radio-frequency ablation (RFA), laser probes, and magnetic nanoparticles in an AC magnetic field. Thermal surgery is a minimally invasive procedure by nature, where its successful application is dependent upon the ability to measure temperatures at critical locations and reconstruct the temperature field in real time. The goal in this line of research is to make temperature-field reconstruction in real time a practical reality. Proof-of-concepts for two key elements are proposed to be developed in the current exploratory study: a miniature wireless temperature-sensing unit and a method to translate temperature data-collected from multiple sensors-to a reconstructed temperature field. While this proposal uses cryosurgery of the prostate as a research model, results of this study are translational to other thermal modalities in medicine. The groundbreaking conceptual design of the new temperature-sensing unit originates from advances in electronics miniaturization and wireless communication. The sensing-unit design consists of three main components: a temperature-sensing core, a wireless transceiver, and a power link. The innovation in this system design is four-fold: (i) the sensor is ultra-miniature-being implanted on a monolithic piece of silicon, where the sensor is of a rice-grain size; (ii) the sensor is passive, receiving its electrical power by means of wireless inductive coupling; (iii) many sensors can communicate simultaneously with a single data receiver; and, (iv) sensor localization can be done under imaging guidance, for example, similarly to radiation seeds localization during brachytherapy (local radiation treatment of the prostate). Three specific aims are set forth in this exploratory study: (1) to develop a wireless temperature-sensing unit, comprising a silicon implant with on-chip inductively-coupled power regulation, a temperature sensor, and a wireless communication interface; (2) to demonstrate feasibility of temperature sensing on a phantom material, using a prostate-cryosurgery simulator, which is an established experimental testing platform, designed to create a 2D-thermal field simulative of prostate cryosurgery; and, (3) to develop a mathematical technique for real-time temperature-field reconstruction for cryosurgery applications. The wider impact of the proposed line of research far exceeds the application of temperature monitoring, where remote power excitation, combined with wireless communication, can serve as a platform for a battery of sensors, and for a wide range of medical applications. PUBLIC HEALTH RELEVANCE: The objective of this study is to develop a wireless implantable temperature sensor for the purpose of feedback and control of thermal surgery. Two key elements are proposed to be developed in this study: a miniature wireless temperature sensor and a method to collect data from multiple sensors, for temperature field reconstruction. While this proposal uses cryosurgery (i.e., the destruction of tissue by freezing) of the prostate as a research model, the outcomes of this study are expected to be translational to high-temperature thermal-surgery applications, such as high-frequency ultrasound, radio-frequency, and laser probes.

描述（由申请人提供）：拟开发无线植入式温度传感器，用于评价和控制热外科手术。热外科手术，或不需要的生物组织的热破坏-如癌性肿瘤-可以通过冷冻（也称为冷冻手术）或通过加热来实现，例如高频超声（HIFU），射频消融（RFA），激光探针和AC磁场中的磁性纳米颗粒。热手术本质上是一种微创手术，其成功应用取决于在关键位置测量温度并真实的重建温度场的能力。 这一研究方向的目标是使真实的温度场重建成为现实。 在目前的探索性研究中，提出了两个关键要素的概念验证：微型无线温度传感单元和将从多个传感器收集的温度数据转换为重建温度场的方法。虽然该提议使用前列腺冷冻手术作为研究模型，但该研究的结果可转化为医学中的其他热模式。 新的温度传感单元的突破性概念设计源于电子小型化和无线通信的进步。 传感单元设计由三个主要组件组成：温度传感核心、无线收发器和电源链路。 该系统设计的创新有四个方面：（i）传感器是超微型的-植入在单片硅上，其中传感器的尺寸为米粒大小;（ii）传感器是无源的，通过无线感应耦合接收其电力;（iii）许多传感器可以同时与单个数据接收器进行通信;以及（iv）可以在成像引导下进行传感器定位，例如类似于近距离放射治疗（前列腺的局部放射治疗）期间的放射种子定位。 本探索性研究提出了三个具体目标：（1）开发一种无线温度传感单元，包括具有片上电感耦合功率调节的硅植入物、温度传感器和无线通信接口;（2）使用前列腺冷冻手术模拟器来证明在体模材料上进行温度感测的可行性，这是一个建立的实验测试平台，旨在创建一个二维热场模拟前列腺冷冻手术;和，（3）开发一种数学技术，用于实时温度场重建冷冻手术的应用。 拟议研究的更广泛影响远远超过了温度监测的应用，其中远程功率激励与无线通信相结合，可以作为传感器电池的平台，并用于广泛的医疗应用。 公共卫生关系：本研究的目的是开发一种无线植入式温度传感器，用于热手术的反馈和控制。提出了两个关键要素，在这项研究中的发展：一个微型无线温度传感器和一种方法，从多个传感器收集数据，温度场重建。虽然该提议使用冷冻手术（即，冷冻对组织的破坏）作为研究模型，该研究的结果有望转化为高温热外科应用，例如高频超声、射频和激光探针。