Passive Foot Movement and Sleep-Disordered Breathing in Heart Failure
心力衰竭患者的被动足部运动和睡眠呼吸障碍
基本信息
- 批准号:7979474
- 负责人:
- 金额:$ 25.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-12 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdverse effectsAgeAir SacsAnimalsApneaAreaArousalBloodBrainBreathingCarbon DioxideCentral Sleep ApneaCerebellumClinicalComorbidityContinuous Positive Airway PressureDataDevicesDisease ProgressionEconomic InflationEffectivenessEnvironmental air flowExperimental DesignsFunctional disorderHeart failureHourHumanIncidenceInterventionLeft Ventricular Ejection FractionLinkMagnetic Resonance ImagingMeasuresMethodsMorbidity - disease rateMotor CortexMovementMuscle TonusObstructive Sleep ApneaOutcomeOxygenPainPatientsPersonsPhasePolysomnographyPre-Post TestsQuestionnairesRandomizedRecording of previous eventsRecruitment ActivityRelative (related person)ReportingRespirationRiskSensorySleepSleep Apnea SyndromesSleep StagesStructureSymptomsTimeUnited Statesclinical practicecompliance behaviordesignexpirationfootfoot solehigh riskimprovedindexinginnovationmortalitynon-compliancenovelpatient populationpreferencepressurepublic health relevancerespiratory
项目摘要
DESCRIPTION (provided by applicant): Sleep-disordered breathing (SDB) is common in heart failure (HF) patients and associated with increased morbidity and mortality. Current treatments for SDB have not been shown to improve survival and often have high non-compliance, lack of efficacy in SDB alleviation, and/or associated with pain. Passive foot movement, the rhythmic movement of feet without voluntary effort, is known to increase ventilation but has not been examined in HF patients. We hypothesize that passive foot movement will decrease SDB (decrease in Apnea-Hypopnea Index [AHI]) with little or no impact on sleep state (fewer arousals during sleep), better sleep (measured by the Pittsburgh Sleep Quality Index Questionnaire) and greater preference for passive foot movement compared to continuous/biphasic positive airway pressure (CPAP/BiPAP - traditional SDB treatment methods). Using a one-group, quasi-experimental, pre- and post-test design, we will examine 26 subjects with advanced HF (left ventricular ejection fraction < 0.40, dilated systolic dysfunction, not in acute HF, age 40-65 years) and SDB (AHI > 5 via overnight polysomnography in the previous 6 months) who will be randomized to undergo passive foot movement either during the first or last half of the night during overnight polysomnography. The specific aims for this study are to: 1) Examine the association between SDB (as indicated by AHI), blood oxygen desaturation, carbon dioxide blood levels and passive foot movement; 2) Examine the association between passive foot movement and changes in sleep stage during an overnight sleep study (polysomnography) in HF patients with SDB; 3) Determine the impact of passive foot movement on subjective reports of sleep quality in HF patients with a history of SDB. The objective is of this study is to determine the relationships between a novel treatment option, passive foot movement, and SDB in HF patients. If passive foot movement decreases SDB and is tolerable to persons with HF, this intervention could have change clinical practice and improve outcomes in this high risk patient population.
PUBLIC HEALTH RELEVANCE: Sleep-disordered breathing is common in heart failure and is associated with increased morbidity and mortality. Current treatments for sleep-disordered breathing have not demonstrated improvement in heart failure outcomes and often are associated with high non-compliance, ineffectiveness, and/or increased risk for pain. Passive foot movement is the rhythmic movement of the feet without voluntary effort, which results in increased ventilation. It is an innovative treatment option for sleep-disordered breathing which has the potential to effectively treat heart failure patients with dramatically decreased risk of adverse effects. If effective, passive foot movement could have important impact on heart failure disease progression and survival.
描述(由申请人提供):睡眠呼吸障碍(SDB)在心力衰竭(HF)患者中很常见,并与发病率和死亡率增加相关。目前的SDB治疗尚未显示出改善生存率,并且通常具有高不依从性,在SDB缓解中缺乏功效,和/或与疼痛相关。被动的足部运动,即无意识的足部节律性运动,已知可增加通气,但尚未在HF患者中进行检查。我们假设被动足部运动将减少SDB(呼吸暂停低通气指数[AHI]下降),对睡眠状态影响很小或没有影响(睡眠期间觉醒次数减少)、睡眠更好(通过匹兹堡睡眠质量指数问卷测量)以及与持续/双相气道正压通气(CPAP/BiPAP -传统的SDB治疗方法)相比,更喜欢被动足部运动。采用单组、准实验、前测和后测设计,我们将检查26名晚期HF受试者(左心室射血分数< 0.40,扩张性收缩功能障碍,不存在于急性HF中,年龄40-65岁)和SDB(过去6个月通过夜间多导睡眠图AHI > 5)在夜间多导睡眠描记期间,这些患者将被随机分配在前半夜或后半夜进行被动足部运动。本研究的具体目的是:1)考察SDB与(如AHI所示)、血氧饱和度下降、二氧化碳血液水平和被动足部运动; 2)检查夜间睡眠研究期间被动足部运动与睡眠阶段变化之间的关联(多导睡眠图); 3)确定被动足部运动对具有SDB病史的HF患者的睡眠质量的主观报告的影响。 本研究的目的是确定一种新的治疗选择,被动足部运动,和SDB在HF患者之间的关系。如果被动足部运动降低SDB并且HF患者可以耐受,则该干预可能会改变临床实践并改善该高风险患者人群的结局。
公共卫生相关性:睡眠呼吸障碍在心力衰竭中很常见,并与发病率和死亡率增加相关。目前对睡眠呼吸障碍的治疗尚未显示出心力衰竭结局的改善,并且通常与高不依从性、无效性和/或疼痛风险增加相关。被动足部运动是足部的有节奏的运动,没有自愿的努力,这导致增加通风。这是一种治疗睡眠呼吸障碍的创新选择,有可能有效地治疗心力衰竭患者,并显著降低不良反应的风险。如果有效,被动足部运动可能对心力衰竭疾病进展和生存率产生重要影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
RONALD Marven HARPER其他文献
RONALD Marven HARPER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('RONALD Marven HARPER', 18)}}的其他基金
Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
截瘫儿童睡眠呼吸障碍和被动肢体运动
- 批准号:
8241281 - 财政年份:2012
- 资助金额:
$ 25.33万 - 项目类别:
Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
截瘫儿童睡眠呼吸障碍和被动肢体运动
- 批准号:
8463626 - 财政年份:2012
- 资助金额:
$ 25.33万 - 项目类别:
Passive Foot Movement and Sleep-Disordered Breathing in Heart Failure
心力衰竭患者的被动足部运动和睡眠呼吸障碍
- 批准号:
8127821 - 财政年份:2010
- 资助金额:
$ 25.33万 - 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
7724342 - 财政年份:2008
- 资助金额:
$ 25.33万 - 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
7627699 - 财政年份:2007
- 资助金额:
$ 25.33万 - 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
7369437 - 财政年份:2006
- 资助金额:
$ 25.33万 - 项目类别:
Neural Sites Mediating Obstructive Sleep Apnea
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
6741089 - 财政年份:2003
- 资助金额:
$ 25.33万 - 项目类别:
NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
6505104 - 财政年份:2001
- 资助金额:
$ 25.33万 - 项目类别:
NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
6349180 - 财政年份:2000
- 资助金额:
$ 25.33万 - 项目类别:
NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
6202626 - 财政年份:1999
- 资助金额:
$ 25.33万 - 项目类别:
相似海外基金
Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
- 批准号:
10591918 - 财政年份:2023
- 资助金额:
$ 25.33万 - 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
- 批准号:
23K15383 - 财政年份:2023
- 资助金额:
$ 25.33万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
- 批准号:
23H03556 - 财政年份:2023
- 资助金额:
$ 25.33万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
- 批准号:
23K17212 - 财政年份:2023
- 资助金额:
$ 25.33万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
- 批准号:
22H03519 - 财政年份:2022
- 资助金额:
$ 25.33万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
- 批准号:
563657-2021 - 财政年份:2022
- 资助金额:
$ 25.33万 - 项目类别:
Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 25.33万 - 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10671022 - 财政年份:2022
- 资助金额:
$ 25.33万 - 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
- 批准号:
10670918 - 财政年份:2022
- 资助金额:
$ 25.33万 - 项目类别:
Adverse Effects of Using Laser Diagnostics in High-Speed Compressible Flows
在高速可压缩流中使用激光诊断的不利影响
- 批准号:
RGPIN-2018-04753 - 财政年份:2022
- 资助金额:
$ 25.33万 - 项目类别:
Discovery Grants Program - Individual