NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA

调节阻塞性睡眠呼吸暂停的神经部位

基本信息

项目摘要

The objectives are to determine, using functional magnetic resonance (fMRI) techniques, the location and time course of activation of brain structures activated during obstructive sleep apnea. We hypothesize that particular regions of the orbital frontal cortex, rostral hypothalamus, amygdala, locus coeruleus, midline raphe, and dorsal and ventral pons, which activate to simulated obstructive apnea in waking control subjects, will fail to activate, or respond with reduced activity during sleep apnea events of patients, but will continue to activate during simulated obstructive apnea during sleep in controls. Other regions involved in the suppression of muscle tone may show excessive activation in patients, thereby inducing obstructive apnea. A time series of 30 repetitions of 20 image slices across the entire brain will be obtained in the sagittal plane using blood oxygen level dependent (BOLD) Echo Planar-Imaging pulse sequences, optimal for sensing perfusion alterations, in 20 obstructive apnea patients and 20 age- and sex-matched controls during apnea events of sleep (patients) and during inspiratory loads (20 cM water) applied at the onset of an inspiratory effort during sleep (controls). To partition effects of sleep, both groups will undergo a baseline waking recording, followed by inspiratory loading, and Valsalva pressor challengers, which simulate sensory and autonomic aspects of obstructive apnea. Heart rate, flow, non-invasive blood pressure, arm sweating, and digit oximetry will be measured concurrently with image scans. The MR signal changes will be assessed with software optimized for fMRI processing to gauge regional activation changes during apneic events, inspiratory loading and sympathetic challenges. Cross correlations of regional image changes with respiratory, cardiovascular and sympathetic outflow induces will be calculated. The studies have the potential to identify brain regions involved in mediating upper airway atonia, to provide insights into pharmacologic intervention for obstructive sleep apnea, and to determine the neural sites involved in autonomic concomitants of airway obstruction.
目的是用功能性磁共振来确定

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

RONALD Marven HARPER其他文献

RONALD Marven HARPER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('RONALD Marven HARPER', 18)}}的其他基金

Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
截瘫儿童睡眠呼吸障碍和被动肢体运动
  • 批准号:
    8241281
  • 财政年份:
    2012
  • 资助金额:
    $ 23.08万
  • 项目类别:
Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
截瘫儿童睡眠呼吸障碍和被动肢体运动
  • 批准号:
    8463626
  • 财政年份:
    2012
  • 资助金额:
    $ 23.08万
  • 项目类别:
Passive Foot Movement and Sleep-Disordered Breathing in Heart Failure
心力衰竭患者的被动足部运动和睡眠呼吸障碍
  • 批准号:
    7979474
  • 财政年份:
    2010
  • 资助金额:
    $ 23.08万
  • 项目类别:
Passive Foot Movement and Sleep-Disordered Breathing in Heart Failure
心力衰竭患者的被动足部运动和睡眠呼吸障碍
  • 批准号:
    8127821
  • 财政年份:
    2010
  • 资助金额:
    $ 23.08万
  • 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
  • 批准号:
    7724342
  • 财政年份:
    2008
  • 资助金额:
    $ 23.08万
  • 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
  • 批准号:
    7627699
  • 财政年份:
    2007
  • 资助金额:
    $ 23.08万
  • 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
  • 批准号:
    7369437
  • 财政年份:
    2006
  • 资助金额:
    $ 23.08万
  • 项目类别:
Neural Sites Mediating Obstructive Sleep Apnea
调节阻塞性睡眠呼吸暂停的神经部位
  • 批准号:
    6741089
  • 财政年份:
    2003
  • 资助金额:
    $ 23.08万
  • 项目类别:
NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
  • 批准号:
    6505104
  • 财政年份:
    2001
  • 资助金额:
    $ 23.08万
  • 项目类别:
NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
  • 批准号:
    6349180
  • 财政年份:
    2000
  • 资助金额:
    $ 23.08万
  • 项目类别:

相似海外基金

Exploring the Neural Mechanisms Underlying Visuospatial Working Memory using 4D Brain Mapping.
使用 4D 大脑映射探索视觉空间工作记忆背后的神经机制。
  • 批准号:
    23KJ2197
  • 财政年份:
    2023
  • 资助金额:
    $ 23.08万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Naturalistic Brain Mapping in Children with Diffuse Optical Tomography
利用漫射光学断层扫描对儿童进行自然脑图绘制
  • 批准号:
    10720660
  • 财政年份:
    2023
  • 资助金额:
    $ 23.08万
  • 项目类别:
Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients
改善术前儿科患者大脑功能图谱的行为反馈和奖励
  • 批准号:
    10707227
  • 财政年份:
    2022
  • 资助金额:
    $ 23.08万
  • 项目类别:
Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients
改善术前儿科患者大脑功能图谱的行为反馈和奖励
  • 批准号:
    10546990
  • 财政年份:
    2022
  • 资助金额:
    $ 23.08万
  • 项目类别:
A generative approach to human brain mapping
人脑绘图的生成方法
  • 批准号:
    RGPIN-2022-04692
  • 财政年份:
    2022
  • 资助金额:
    $ 23.08万
  • 项目类别:
    Discovery Grants Program - Individual
Dissemination of MAPseq and BARseq for high-throughput brain mapping
传播用于高通量脑图谱的 MAPseq 和 BARseq
  • 批准号:
    10440138
  • 财政年份:
    2022
  • 资助金额:
    $ 23.08万
  • 项目类别:
Dissemination of MAPseq and BARseq for High-Throughput Brain Mapping
传播用于高通量脑图谱的 MAPseq 和 BARseq
  • 批准号:
    10669012
  • 财政年份:
    2022
  • 资助金额:
    $ 23.08万
  • 项目类别:
The Development of Tabletop Brain-Mapping Platform
桌面脑图平台的开发
  • 批准号:
    10553063
  • 财政年份:
    2022
  • 资助金额:
    $ 23.08万
  • 项目类别:
CREST Center for Dynamic Multiscale and Multimodal Brain Mapping Over The Lifespan [D-MAP]
CREST 生命周期动态多尺度和多模式脑图谱中心 [D-MAP]
  • 批准号:
    2112455
  • 财政年份:
    2021
  • 资助金额:
    $ 23.08万
  • 项目类别:
    Continuing Grant
The Development of Tabletop Brain-Mapping Platform
桌面脑图平台的开发
  • 批准号:
    10487512
  • 财政年份:
    2021
  • 资助金额:
    $ 23.08万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了