NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
基本信息
- 批准号:6202626
- 负责人:
- 金额:$ 23.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-01 至 2000-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objectives are to determine, using functional magnetic resonance
(fMRI) techniques, the location and time course of activation of brain
structures activated during obstructive sleep apnea. We hypothesize that
particular regions of the orbital frontal cortex, rostral hypothalamus,
amygdala, locus coeruleus, midline raphe, and dorsal and ventral pons,
which activate to simulated obstructive apnea in waking control subjects,
will fail to activate, or respond with reduced activity during sleep apnea
events of patients, but will continue to activate during simulated
obstructive apnea during sleep in controls. Other regions involved in the
suppression of muscle tone may show excessive activation in patients,
thereby inducing obstructive apnea. A time series of 30 repetitions of 20
image slices across the entire brain will be obtained in the sagittal
plane using blood oxygen level dependent (BOLD) Echo Planar-Imaging pulse
sequences, optimal for sensing perfusion alterations, in 20 obstructive
apnea patients and 20 age- and sex-matched controls during apnea events of
sleep (patients) and during inspiratory loads (20 cM water) applied at the
onset of an inspiratory effort during sleep (controls). To partition
effects of sleep, both groups will undergo a baseline waking recording,
followed by inspiratory loading, and Valsalva pressor challengers, which
simulate sensory and autonomic aspects of obstructive apnea. Heart rate,
flow, non-invasive blood pressure, arm sweating, and digit oximetry will
be measured concurrently with image scans. The MR signal changes will be
assessed with software optimized for fMRI processing to gauge regional
activation changes during apneic events, inspiratory loading and
sympathetic challenges. Cross correlations of regional image changes with
respiratory, cardiovascular and sympathetic outflow induces will be
calculated. The studies have the potential to identify brain regions
involved in mediating upper airway atonia, to provide insights into
pharmacologic intervention for obstructive sleep apnea, and to determine
the neural sites involved in autonomic concomitants of airway obstruction.
目的是用功能性磁共振来确定
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RONALD Marven HARPER其他文献
RONALD Marven HARPER的其他文献
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{{ truncateString('RONALD Marven HARPER', 18)}}的其他基金
Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
截瘫儿童睡眠呼吸障碍和被动肢体运动
- 批准号:
8241281 - 财政年份:2012
- 资助金额:
$ 23.08万 - 项目类别:
Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
截瘫儿童睡眠呼吸障碍和被动肢体运动
- 批准号:
8463626 - 财政年份:2012
- 资助金额:
$ 23.08万 - 项目类别:
Passive Foot Movement and Sleep-Disordered Breathing in Heart Failure
心力衰竭患者的被动足部运动和睡眠呼吸障碍
- 批准号:
7979474 - 财政年份:2010
- 资助金额:
$ 23.08万 - 项目类别:
Passive Foot Movement and Sleep-Disordered Breathing in Heart Failure
心力衰竭患者的被动足部运动和睡眠呼吸障碍
- 批准号:
8127821 - 财政年份:2010
- 资助金额:
$ 23.08万 - 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
7724342 - 财政年份:2008
- 资助金额:
$ 23.08万 - 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
7627699 - 财政年份:2007
- 资助金额:
$ 23.08万 - 项目类别:
NEURAL SITES MEDIATING OBSTGRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
7369437 - 财政年份:2006
- 资助金额:
$ 23.08万 - 项目类别:
Neural Sites Mediating Obstructive Sleep Apnea
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
6741089 - 财政年份:2003
- 资助金额:
$ 23.08万 - 项目类别:
NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
6505104 - 财政年份:2001
- 资助金额:
$ 23.08万 - 项目类别:
NEURAL SITES MEDIATING OBSTRUCTIVE SLEEP APNEA
调节阻塞性睡眠呼吸暂停的神经部位
- 批准号:
6349180 - 财政年份:2000
- 资助金额:
$ 23.08万 - 项目类别:
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