Lung Desease Models Core
Lung Desease Models Core
批准号:
7977207
负责人:
STEPHEN Lloyd TILLEY
金额:
$22.16万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-03-01 至 2013-02-28
关键词:
AcuteAirway ResistanceAllergensAllergicAnimal ModelAnimalsAntigensAsthmaBiochemicalBiologyBreedingCell CountChronicComputersDataDevelopmentDiseaseDisease modelEndotoxinsEnvironmental PollutantsEosinophiliaEvaluationExposure toFormalinFreezingGenesGeneticGoalsHarvestHistologyHumanImmunobiologyIndividualInflammationInterventionLaboratory miceLipidsLungLung InflammationLung Lavage FluidLung diseasesMeasurableMeasurementMeasuresMechanicsMessenger RNAMissionModelingMouse StrainsMucous body substanceMusNational Institute of Allergy and Infectious DiseaseObstructionParalysedPathogenesisPeripheralPhasePhenotypePhysiologicalProductionProteinsProtocols documentationPublic HealthResearch PersonnelResistanceResourcesRoleSerumServicesSignal PathwayStructure of parenchyma of lungTechnical ExpertiseTestingTissue BanksTissuesToxic effectTransgenic OrganismsVentilatorWild Type MouseWorkairway hyperresponsivenessairway inflammationairway remodelingdesignefficacy testingembryonic stem cellenvironmental agentgenetic technologyhuman diseaseimprovedin vivointerestmeetingsmethacholinemolecular phenotypemouse modelnovelprotein expressionresponse
中文摘要
这个核心的长期目标是为对环境肺病感兴趣的研究人员提供
在小鼠体内进行机械学研究所需的资源和技术专长。以下是
将提供核心服务:1)老鼠的进口和出口;2)野生鼠的繁育
机理研究,3)遗传操作小鼠品系的培育和基因分型
机制研究,4)用急性和慢性致敏/激发建立过敏性小鼠
方案,5)动物暴露于模型环境污染物,6)治疗干预措施,以测试
新疗法的有效性、毒性和作用机制,以及7)小鼠的生理表型
在诱发环境肺疾病后评估呼吸道阻力、顺应性和呼吸道
对乙酰甲胆碱的高反应性。这一核心支持了NIAID研究遗传和
与环境肺病相关的环境相互作用。动物的机械学研究,
尤其是使用基因操纵的小鼠,对于开发新的治疗方法是必不可少的
改善公共卫生。
英文摘要
The long-term objective of this core is to provide investigators interested in environmental lung disease the
resources and technical expertise required to conduct in vivo mechanistic studies in mice. The following
core services will be provided: 1) importation and exportation of mice, 2) breeding of wild type mice for
mechanistic studies, 3) breeding and genotying of genetically manipulated mouse lines for use in
mechanistic studies, 4) development of allergic mice using both acute and chronic sensitization/challenge
protocols, 5) exposure of animals to model environmental pollutants, 6) treatment interventions to test the
efficacy, toxicity, and mechanisms of action of novel therapies, and 7) physiological phenotyping of mice
after the induction of environmental lung disease for evaluation of airway resistance, compliance, and airway
hyperresponsiveness to methacholine. This core supports the mission of NIAID to study genetic and
environmental interactions as they relate to environmental lung disease. Mechanistic studies in animals,
particularly the use of genetically manipulated mice, is essential for the development of new therapies to
improve public health.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Adenosine receptors as therapeutic targets for chronic rhinosinusitis
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批准号:8415507
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项目类别:
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资助金额:$22.2万
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财政年份:2012
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负责人:STEPHEN Lloyd TILLEY
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依托单位:
Role of Adenosine in Allergic Lung Disease
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批准号:7822528
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项目类别:
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资助金额:$1.72万
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财政年份:2009
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负责人:STEPHEN Lloyd TILLEY
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依托单位:
Lung Desease Models Core
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批准号:7476122
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项目类别:
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资助金额:$21.24万
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财政年份:2008
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负责人:STEPHEN Lloyd TILLEY
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依托单位:
Role of propionibacteria in sarcoidosis
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批准号:6941641
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项目类别:
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资助金额:$21.9万
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财政年份:2004
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负责人:STEPHEN Lloyd TILLEY
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依托单位:
Role of Adenosine in Allergic Lung Disease
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批准号:6987162
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项目类别:
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资助金额:$32.08万
-
财政年份:2004
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负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of Adenosine in Allergic Lung Disease
-
批准号:6729839
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项目类别:
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资助金额:$18.25万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of Adenosine in Allergic Lung Disease
-
批准号:7667775
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项目类别:
-
资助金额:$37.0万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of Adenosine in Allergic Lung Disease
-
批准号:7882355
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项目类别:
-
资助金额:$37.0万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of Adenosine in Allergic Lung Disease
-
批准号:6839463
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项目类别:
-
资助金额:$32.85万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of propionibacteria in sarcoidosis
-
批准号:6816509
-
项目类别:
-
资助金额:$14.6万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of Adenosine in Allergic Lung Disease
-
批准号:7148686
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项目类别:
-
资助金额:$31.15万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of Adenosine in Allergic Lung Disease
-
批准号:7528924
-
项目类别:
-
资助金额:$36.88万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Role of Adenosine in Allergic Lung Disease
-
批准号:8100394
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项目类别:
-
资助金额:$37.0万
-
财政年份:2004
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
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批准号:6536631
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项目类别:
-
资助金额:$12.5万
-
财政年份:2000
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
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批准号:6388641
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项目类别:
-
资助金额:$12.22万
-
财政年份:2000
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
-
批准号:6735644
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项目类别:
-
资助金额:$12.6万
-
财政年份:2000
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
-
批准号:6638150
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项目类别:
-
资助金额:$12.6万
-
财政年份:2000
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
-
批准号:6086057
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项目类别:
-
资助金额:$11.02万
-
财政年份:2000
-
负责人:STEPHEN Lloyd TILLEY
-
依托单位:
Lung Desease Models Core
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批准号:8019516
-
项目类别:
-
资助金额:$25.94万
-
财政年份:--
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负责人:STEPHEN Lloyd TILLEY
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依托单位:
Lung Desease Models Core
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批准号:8229936
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项目类别:
-
资助金额:$22.38万
-
财政年份:--
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负责人:STEPHEN Lloyd TILLEY
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依托单位:
海外基金