Lung Desease Models Core

这个核心的长期目标是为对环境肺病感兴趣的研究人员提供 在小鼠体内进行机械学研究所需的资源和技术专长。以下是 将提供核心服务：1)老鼠的进口和出口；2)野生鼠的繁育 机理研究，3)遗传操作小鼠品系的培育和基因分型 机制研究，4)用急性和慢性致敏/激发建立过敏性小鼠 方案，5)动物暴露于模型环境污染物，6)治疗干预措施，以测试 新疗法的有效性、毒性和作用机制，以及7)小鼠的生理表型 在诱发环境肺疾病后评估呼吸道阻力、顺应性和呼吸道 对乙酰甲胆碱的高反应性。这一核心支持了NIAID研究遗传和 与环境肺病相关的环境相互作用。动物的机械学研究， 尤其是使用基因操纵的小鼠，对于开发新的治疗方法是必不可少的 改善公共卫生。

The long-term objective of this core is to provide investigators interested in environmental lung disease the resources and technical expertise required to conduct in vivo mechanistic studies in mice. The following core services will be provided: 1) importation and exportation of mice, 2) breeding of wild type mice for mechanistic studies, 3) breeding and genotying of genetically manipulated mouse lines for use in mechanistic studies, 4) development of allergic mice using both acute and chronic sensitization/challenge protocols, 5) exposure of animals to model environmental pollutants, 6) treatment interventions to test the efficacy, toxicity, and mechanisms of action of novel therapies, and 7) physiological phenotyping of mice after the induction of environmental lung disease for evaluation of airway resistance, compliance, and airway hyperresponsiveness to methacholine. This core supports the mission of NIAID to study genetic and environmental interactions as they relate to environmental lung disease. Mechanistic studies in animals, particularly the use of genetically manipulated mice, is essential for the development of new therapies to improve public health.