INFLUENCE OF PENTOBARBITAL ON UPPER AIRWAY RESISTANCE AND COLLABSIBILITY

戊巴比妥对上呼吸道阻力和塌陷性的影响

• 批准号: 7606977
• 负责人: Atul Malhotra
• 金额: $ 2.17万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606977
• 关键词: Airway Resistance; Breathing; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Disease; Dose; Funding; Grant; Institution; Lung; Muscle; Muscle function; Obstructive Sleep Apnea; Patients; Pentobarbital; Pharmaceutical Preparations; Purpose; Research; Research Personnel; Resources; Risk; Sales; Sleep; Sleeplessness; Source; United States Food and Drug Administration; United States National Institutes of Health; falls; sedative

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine how the muscles of the upper airway, the upper airway itself, and the lung respond to low doses of the sedative drug pentobarbital. Pentobarbital is approved by the FDA for sale as a medication against 'insomnia' (patient's dissatisfaction with the quality of sleep). Pentobarbital has been used frequently and safely for decades in patients with insomnia, and recent findings suggest that this drug may also be useful for treatment of patients with a disease called obstructive sleep apnea (OSA). Patients with OSA are not able to breathe normally during sleep, resulting in severe daytime sleepiness and an increased risk of developing cardiovascular diseases. Typically, the muscles that hold open the upper airway, relax in patients with OSA while falling asleep resuting in an upper airway collapse. This causes the patietns to stop breathing and to wake up some seconds later. It has been shown that this brief awakening at the end of an obstructive sleep apnea episode makes it more likely to develop breathing problems in the next several breaths. Pentobarbital may be useful for treatmetn of OSA, because this drug makes patients wake up less easilty and may alsoimprove the function of the muscles that open the airway.

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