Microarray Center for Research on the Nervous System

描述（由申请人提供）： 翻译基因组学研究所（TGen），目前的NINDS NIMH微阵列联盟中心，提供这种更新申请。将提供实验设计、数据生成、数据解释和数据传播方面的最高质量协助。TGen已经为NINDS和NIMH的校外研究者/财团履行了这些功能，并拥有完善的协议、网站和数据库以及生物信息学方法，这些方法允许以低成本实现高通量。TGen中心团队是唯一合格的，因为我们通过以下方式积累了大量的专业知识：1）在过去两年中作为联盟网站执行了相同的功能，2）成为Affytechnology技术的“卓越中心”，3）开发联盟门户网站（arrayconsortium.tgen.org），用于教程，透明的工作流程管理和进度监控，角色相关信息访问和数据传播，4）确保符合MIAME标准的数据，并为符合HIPAA标准的数据共享构建第一个MAGE-ML翻译引擎，5）精通表达式技术（Jeffrey Trent博士参与开发阵列技术，PI在过去七年中与Affyscreen技术合作），6）在联合体成立的头两年里，为联合体进行了超过2635次的Affyoung阵列实验，并获得了良好的评价，7）TGen中心的运营与商业基础设施，以及8）Stephan博士在整个3年的存在中担任联盟主席。我们建议继续运营我们的NINDS NIMH微阵列中心。拟议的结构/职能以经验为基础，但建议中的研究与发展部分除外。这些目标包括：1）通过网络提交教程和项目，2）由具有神经科学经验的内部审查委员会审查，3）整个联盟服务的标准化定价，4）在Affyoung股票芯片和分析上生成数据，5）6个月定时向公众发布的数据仓库，以及6）技术开发。

DESCRIPTION (provided by applicant): The Translational Genomics Research Institute (TGen), a current NINDS NIMH Microarray Consortium center, offers this renewal application. The highest quality assistance with experimental design, data generation, data interpretation, and data dissemination will be provided. TGen already fulfills these functions for NINDS and NIMH extramural investigators/consortia, and has well-established protocols, web site and data repository, and bioinformatic methods which permit a high degree of throughput at low cost. The TGen center team are uniquely qualified because we have amassed significant expertise through 1) having performed this identical function as a consortium site for the past two years, 2) becoming a "Center of Excellence" for Affymetrix technology, 3) development of the consortium web portal (arrayconsortium.tgen.org) for tutorials, transparent work-flow management and progress monitoring, role dependent information access, and data dissemination, 4) ensuring MIAME compliant data and building the first MAGE-ML translation engine for HIPAA-compliant data sharing, 5) being well-versed in expression technology (Dr. Jeffrey Trent was involved in developing array technologies and the PI working with Affymetrix technology for the past seven years), 6) having performed over 2635 Affymetrix array experiments for the consortium in its first two years and receiving excellent reviews, 7) operation of the TGen center with a business infrastructure, and 8) having Dr. Stephan Chair the consortium for its entire 3 year existence. We propose to continue operating our NINDS NIMH Microarray Center. The proposed structure/function is anchored in experience, except for the R&D portions of the proposal. The goals include: 1) tutorials and project submission via the web, 2) review by an internal review committee with neuroscience experience, 3) standardized pricing for services across the consortium, 4) data generation on Affymetrix stock chips and analysis, 5) data warehousing with 6 month timed release to the public, and 6) technology development.