Genome Characterization Unit

基因组表征单位

• 批准号: 10294887
• 负责人: David W Craig
• 金额: $ 171.95万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294887
• 关键词: Address; Area; Automation; Behavioral Sciences; Bioinformatics; California; Cancer Biology; Clinical; Clinical Data; Collaborations; Collection; Colorectal Cancer; Communication; Communities; Complement; Copy Number Polymorphism; DNA Methylation; DNA analysis; DNA methylation profiling; Data; Data Set; Detection; Development; Diagnosis; Emerging Technologies; Ensure; Epidemiology; Event; Feedback; Foundations; Funding Opportunities; Gene Mutation; Generations; Genes; Genetic Counseling; Genome; Genomic Data Commons; Genomics; Goals; Guidelines; Hispanics; Knowledge; Latino; Lead; Leadership; Malignant Neoplasms; Measurement; Mission; Molecular; Oncology; Patient Recruitments; Patients; Performance; Population; Predictive Value; Process; Program Evaluation; Publications; Quality Control; Reporting; Reproducibility; Research; Research Institute; Resources; Scanning; Scientist; Services; Specimen; Strategic Planning; Structure; Supervision; Transcript; Universities; Untranslated RNA; Validation; Variant; Vision; Work; base; cancer genome; cancer genomics; clinical sequencing; clinically relevant; colon cancer patients; exome sequencing; experience; flexibility; genome sequencing; genome-wide; implementation strategy; improved; mRNA sequencing; medical schools; member; next generation sequencing; novel; patient engagement; patient population; prognostic value; research clinical testing; transcriptome sequencing; translational genomics; tumor; tumor DNA; tumor exome; whole genome

ABSTRACT: ADMINISTRATIVE CORE (AC) The mission of the University of Southern California (USC) Center for Optimization of Participant Engagement for Cancer Characterization (USC COPECC) is to provide both the biomedical and patient communities with optimized best practices for Participant Engagement in genomic research, specifically in the context of Hispanic patients diagnosed with Colorectal Cancer (CRC). USC COPECC will operate as an NCI U2C Participant Engagement in Cancer Genome Sequencing (PE-CGS) Center, and will participate as a member of the NCI PE- CGS Network. COPECC will be locally managed by the Administrative Core (AC), which will serve as the hub of the Center's activities, including the management, coordination, supervision and promotion of the Center activities. USC COPECC builds on the strong foundation of a significantly diverse and Hispanic enriched patient population, established standard processes for Participant Engagement and recruitment into genomic studies, highly experienced genome scientists with vast experience in clinical cancer genomics, and strong leadership in the areas of oncology, genetic counseling, epidemiology, and behavioral science. The administrative leadership will be primarily responsible for the Center's strategic planning, including: defining and upholding its mission and objectives, conducting environmental scanning for strategy development, directing and managing strategy implementation, and ensuring adjustments are made for continuous quality improvement (CQI) based on program evaluation.

摘要：行政核心(AC) 南加州大学(USC)参与者参与度优化中心的使命 癌症表征(USC COPECC)是为生物医学和患者社区提供 优化参与者参与基因组研究的最佳做法，特别是在西班牙裔背景下 诊断为结直肠癌(CRC)的患者。南加州大学COPECC将作为NCI U2C参与者运营 参与癌症基因组测序(PE-CGS)中心，并将作为NCI PE- CGS网络。COPECC将由行政核心(AC)在当地管理，AC将作为 中心的活动，包括中心的管理、协调、监督和促进 活动。南加州大学COPECC建立在显著多样化和拉美裔患者的坚实基础上 人口，建立了参与者参与和招募到基因组研究中的标准程序， 经验丰富的基因组科学家，在临床癌症基因组学方面拥有丰富的经验，并在 肿瘤学、遗传咨询、流行病学和行为科学领域。行政领导 将主要负责中心的战略规划，包括：确定和维护其使命和 目标，进行战略制定的环境扫描，指导和管理战略 实施，并确保针对持续质量改进(CQI)进行调整 计划评估。