Characterizing Prostate Cancer By ex vivo MRS Signatures

通过离体 MRS 特征表征前列腺癌

• 批准号: 7914796
• 负责人: Leo L Cheng
• 金额: $ 53.59万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7914796
• 关键词: Accounting; Adenocarcinoma; Adjuvant Therapy; Affect; American; Behavior; Benign; Benign Prostatic Hypertrophy; Biochemical; Biological; Biology; Biomedical Engineering; Biopsy; Biopsy Specimen; Cancer Etiology; Cancer Patient; Cells; Cessation of life; Chemicals; Clinical; Consultations; Data; Detection; Development; Diagnosis; Diagnostic; Diagnostic Neoplasm Staging; Diagnostic tests; Disease; Early Diagnosis; Engineering; Evaluation; Exploratory/Developmental Grant for Diagnostic Cancer Imaging; Gleason Grade for Prostate Cancer; Goals; Health behavior; Histologic; Histopathology; Human; Individual; Investigation; Knowledge; Laboratories; Magic; Magnetic Resonance Spectroscopy; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Measures; Metabolic; Methods; Modality; Morphology; Nature; Operative Surgical Procedures; Outcome; PSA screening; Pathological Staging; Patients; Personal Satisfaction; Population; Probability; Prostate; Prostate Adenocarcinoma; Prostatectomy; Prostatic Intraepithelial Neoplasias; Prostatic Neoplasms; Protocols documentation; Protons; Recurrent disease; Research; Research Personnel; Research Project Grants; Resolution; Risk; Sampling; Specificity; Specimen; Staging; Structure; System; Techniques; Testing; Tissues; Treatment Failure; United States National Institutes of Health; base; cancer care; cancer diagnosis; clinical practice; cost; experience; human tissue; improved; in vivo; men; outcome forecast; patient population; prevent; prognostic; success; tool; treatment planning; tumor

DESCRIPTION (provided by applicant): For two decades, PSA testing has been employed routinely in clinical practice. The outstanding success of this approach, with its emphasis on early detection of malignancy, can be judged by one key distinction between today's prostate cancer patient population and that of 20 years ago: today, >70% of prostate cancer patients are diagnosed with asymptomatic, moderately differentiating adenocarcinomas. Despite this accomplishment, prostate cancer remains the second leading cause of cancer death among American men. The diversity of outcomes observed for this >70% of PCa patients who seek treatment for Gleason score 6 and 7 tumors, as determined by tumor morphology, points to an underlying weakness in the evaluation of prostate tumors, and indicates insufficient specificity in their current description. It is likely that tumor aggressiveness, a crucially informative feature that cannot now be assessed without prostatectomy, accounts for the unpredictable outcomes experienced by these patients. For most of them, decisions on treatment must be determined in the absence of information about tumor behavior and aggressiveness, and in spite of the fact that the selected course may prove to be inappropriate. Preliminary studies of high resolution magic-angle-spinning proton magnetic resonance spectroscopy (HRMAS 1HMRS) as a tool for sensitively and quantitatively probing the underlying biology and behavior of prostate tumors have produced significant results. These results support the technique's potential value for prostate cancer diagnosis and treatment planning. This proposal seeks to correlate metabolic profiles of intact prostatectomy tissue, measured by HRMAS 1HMRS, with both prostate tissue histopathological features and the clinical status of individual patients, in order to establish prostate cancer metabolic profiles and to define cancer signatures. It then aims to test the diagnostic efficacy, confirmed by histopathology, of these respective markers for predicting pathological stage and patient clinical status in both prostatectomy specimens and biopsy samples. Finally, it plans to assess longitudinally the prognostic capability of tumor metabolic profiles, independent of histopathology, to predict specific tumor behavior and patient outcome. Relevance: the overall goal of the project is to improve the accuracy of prostate cancer diagnosis, to contribute to the patient well-being, as well as to reduce costs related prostate cancer cares.

描述（由申请人提供）：二十年来，PSA 检测已在临床实践中常规使用。这种强调早期发现恶性肿瘤的方法取得了巨大成功，可以通过当今前列腺癌患者群体与 20 年前的一个关键区别来判断：如今，>70% 的前列腺癌患者被诊断为无症状、中分化腺癌。尽管取得了这一成就，前列腺癌仍然是美国男性癌症死亡的第二大原因。对于格里森评分为 6 和 7 的肿瘤寻求治疗的 >70% 的 PCa 患者观察到的结果的多样性（根据肿瘤形态确定）表明前列腺肿瘤评估存在潜在的弱点，并表明目前的描述缺乏特异性。肿瘤侵袭性是一种至关重要的信息特征，如果不进行前列腺切除术就无法对其进行评估，这很可能解释了这些患者所经历的不可预测的结果。对于大多数人来说，治疗决定必须在缺乏有关肿瘤行为和侵袭性的信息的情况下做出，尽管所选择的疗程可能被证明是不合适的。高分辨率魔角旋转质子磁共振波谱（HRMAS 1HMRS）作为敏感和定量探测前列腺肿瘤的潜在生物学和行为的工具的初步研究已经产生了显着的结果。这些结果支持了该技术对于前列腺癌诊断和治疗计划的潜在价值。该提案旨在将 HRMAS 1HMRS 测量的完整前列腺切除组织的代谢特征与前列腺组织组织病理学特征和个体患者的临床状态相关联，以便建立前列腺癌代谢特征并定义癌症特征。然后旨在测试经组织病理学证实的这些各自标记物的诊断功效，以预测前列腺切除标本和活检样本中的病理阶段和患者临床状态。最后，它计划纵向评估肿瘤代谢谱的预后能力，独立于组织病理学，以预测特定的肿瘤行为和患者结果。相关性：该项目的总体目标是提高前列腺癌诊断的准确性，为患者的福祉做出贡献，并降低与前列腺癌护理相关的成本。