Upgrade of Console for 600 MHz MR Spectrometer

600 MHz 磁共振波谱仪控制台升级

• 批准号: 9272595
• 负责人: Leo L Cheng
• 金额: $ 60万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-17 至 2020-03-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9272595
• 关键词: Accounting; Advisory Committees; Automobile Driving; Award; Boston; Brain Mapping; Cardiology; Cardiovascular Diseases; Cell Nucleus; Communities; Computer software; Ensure; Evolution; Funding; Future; General Hospitals; Image; Imaging technology; Leadership; Magnetic Resonance Spectroscopy; Maintenance; Malignant Neoplasms; Manufacturer Name; Massachusetts; Medical; Medical Imaging; Methods; Minor; Mission; Operative Surgical Procedures; Pathology; Price; Radiology Specialty; Research; Research Personnel; Resolution; Resource Sharing; Role; Schedule; Services; System; Techniques; Technology; Temperature; Translations; United States National Institutes of Health; bench to bedside; bioimaging; cost effective; instrument; neurochemistry; operation; pre-clinical; technological innovation; technology development

Project Summary/Abstract We request funds to upgrade the console of the wide-bore 600MHz MR spectrometer and micro-imager, located in the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital. The current system acquired in 2003 with funds from an NIH SIG award and institutional support has been an essential component of a regional shared resource for pre-clinical medical imaging, and has contributed tremendously to the scientific discoveries and technological innovations of the Martinos Center and local investigators. However, after more than a decade in service, the current system is outdated. It is not only incompatible with the manufacturer's newly developed features and methods for cutting-edge MR spectroscopy and micro-imaging, but most dreadfully, the manufacturer has ceased to provide services on this vintage instrument due to the evolution of technologies and the lack of outdated replacement parts. To continue and enhance its integrated contributions to the Martinos Center's dual mission of imaging technology development and bench-to-bedside translation, this 600MHz system is in critical and urgent need of an upgrade. We request funds to upgrade the console, including its hardware and software, and necessary accompanying components, and will use its still functioning parts (magnet and NMR probes, etc.). Through this proposed upgrade, the system, with its high-field, high-resolution, multi-nucleus MR spectroscopy and micro- imaging capacities, and state-of-the-art techniques, will greatly benefit the NIH-funded projects proposed by the diverse user group, including 17 projects from 12 Major Users and 5 Minor Users. The proposed upgrade through this SIG has been supported by all levels of institutional administration, from the MGH leadership, to the Radiology Department, and the Martinos Center. This support covers every aspect related to the upgrade and its future operations, including allocation of instrument space and assistance for installation, operational support in terms of system scheduling, accounting, and maintenance, guarantees from the leaderships to supply additional funds, if necessary, for unexpected shortfalls, and lastly but most significantly, a commitment of up to $225,000 to cover the gap between the NIH SIG award and the purchasing price for the upgrade, in addition to the committed fund of $100,000 from the MGH Executive Committee for Research towards the maintenance of the system. Following the upgrade, the 600MHz MR spectrometer and micro-imager with the capability of temperature control (-80°C to 200°C), managed by the Martinos Center as a shared core, will be available to the broader research community, both within MGH and the Greater Boston region. The PI and Advisory Committee will ensure equitable and cost-effective operation of the system to achieve its essential role in driving new discoveries pertaining to a host of medically related issues covering the fields of radiology, pathology, cardiology, and surgery, and subjects including brain mapping, neurochemistry, photomedicine, cardiovascular disease, and cancer.

项目总结/摘要 我们申请资金来升级宽口径600兆赫磁共振光谱仪和显微成像仪的控制台， 位于Athinoula A。马萨诸塞州总医院马蒂诺生物医学成像中心。的 2003年，在NIH SIG奖和机构支持的资助下， 临床前医学成像区域共享资源的重要组成部分，并为 极大地促进了Martinos中心和当地的科学发现和技术创新， investigators.然而，经过十多年的使用，目前的系统已经过时。它不仅是 与制造商新开发的尖端MR功能和方法不兼容 光谱和显微成像，但最可怕的是，制造商已停止提供这方面的服务， 由于技术的发展和缺乏过时的替换零件， 继续并加强其对马蒂诺斯中心成像双重使命的综合贡献 技术发展和从工作台到床边的转变，这一600 MHz系统是关键和迫切需要的， 升级。我们要求资金升级控制台，包括其硬件和软件，以及必要的 它将使用其仍然功能正常的部件（磁体和NMR探头等）。通过这个 建议升级，该系统，其高场，高分辨率，多核磁共振波谱和微- 成像能力和最先进的技术，将大大有利于NIH资助的项目提出的 多样化的用户群，包括来自12个主要用户和5个次要用户的17个项目。 通过这一所指政府提出的升级建议得到了各级机构管理部门的支持， 从MGH领导层到放射科和Martinos中心。这种支持涵盖了所有 与升级及其未来运作有关的方面，包括仪器空间的分配和援助 在系统调度、会计和维护方面提供安装、操作支持，保证 从领导提供额外的资金，如果必要的话，意外的短缺，最后，但最重要的是 重要的是，高达225，000美元的承诺，以弥补NIH SIG奖励和购买之间的差距 除了MGH执行委员会承诺的100，000美元资金外， 对系统的维护进行了研究。升级后，600 MHz MR光谱仪和 具有温度控制能力（-80 ° C至200°C）的显微成像仪，由Martinos中心管理， 共享核心，将提供给更广泛的研究社区，无论是在MGH和大波士顿 地区PI和咨询委员会将确保该系统的公平和成本效益的运作， 在推动与一系列医学相关问题有关的新发现方面发挥重要作用， 放射学、病理学、心脏病学和外科学领域，以及包括脑映射、神经化学、 光医学、心血管疾病和癌症。

项目成果

Screening human lung cancer with predictive models of serum magnetic resonance spectroscopy metabolomics.

• DOI: 10.1073/pnas.2110633118
• 发表时间: 2021-12-21
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Schult, Tjada A;Lauer, Mara J;Cheng, Leo L
• 通讯作者: Cheng, Leo L