Upgrade of Console for 600 MHz MR Spectrometer

600 MHz 磁共振波谱仪控制台升级

• 批准号: 9272595
• 负责人: Leo L Cheng
• 金额: $ 60万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-17 至 2020-03-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9272595
• 关键词: Accounting; Advisory Committees; Automobile Driving; Award; Boston; Brain Mapping; Cardiology; Cardiovascular Diseases; Cell Nucleus; Communities; Computer software; Ensure; Evolution; Funding; Future; General Hospitals; Image; Imaging technology; Leadership; Magnetic Resonance Spectroscopy; Maintenance; Malignant Neoplasms; Manufacturer Name; Massachusetts; Medical; Medical Imaging; Methods; Minor; Mission; Operative Surgical Procedures; Pathology; Price; Radiology Specialty; Research; Research Personnel; Resolution; Resource Sharing; Role; Schedule; Services; System; Techniques; Technology; Temperature; Translations; United States National Institutes of Health; bench to bedside; bioimaging; cost effective; instrument; neurochemistry; operation; pre-clinical; technological innovation; technology development

Project Summary/Abstract We request funds to upgrade the console of the wide-bore 600MHz MR spectrometer and micro-imager, located in the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital. The current system acquired in 2003 with funds from an NIH SIG award and institutional support has been an essential component of a regional shared resource for pre-clinical medical imaging, and has contributed tremendously to the scientific discoveries and technological innovations of the Martinos Center and local investigators. However, after more than a decade in service, the current system is outdated. It is not only incompatible with the manufacturer's newly developed features and methods for cutting-edge MR spectroscopy and micro-imaging, but most dreadfully, the manufacturer has ceased to provide services on this vintage instrument due to the evolution of technologies and the lack of outdated replacement parts. To continue and enhance its integrated contributions to the Martinos Center's dual mission of imaging technology development and bench-to-bedside translation, this 600MHz system is in critical and urgent need of an upgrade. We request funds to upgrade the console, including its hardware and software, and necessary accompanying components, and will use its still functioning parts (magnet and NMR probes, etc.). Through this proposed upgrade, the system, with its high-field, high-resolution, multi-nucleus MR spectroscopy and micro- imaging capacities, and state-of-the-art techniques, will greatly benefit the NIH-funded projects proposed by the diverse user group, including 17 projects from 12 Major Users and 5 Minor Users. The proposed upgrade through this SIG has been supported by all levels of institutional administration, from the MGH leadership, to the Radiology Department, and the Martinos Center. This support covers every aspect related to the upgrade and its future operations, including allocation of instrument space and assistance for installation, operational support in terms of system scheduling, accounting, and maintenance, guarantees from the leaderships to supply additional funds, if necessary, for unexpected shortfalls, and lastly but most significantly, a commitment of up to $225,000 to cover the gap between the NIH SIG award and the purchasing price for the upgrade, in addition to the committed fund of $100,000 from the MGH Executive Committee for Research towards the maintenance of the system. Following the upgrade, the 600MHz MR spectrometer and micro-imager with the capability of temperature control (-80°C to 200°C), managed by the Martinos Center as a shared core, will be available to the broader research community, both within MGH and the Greater Boston region. The PI and Advisory Committee will ensure equitable and cost-effective operation of the system to achieve its essential role in driving new discoveries pertaining to a host of medically related issues covering the fields of radiology, pathology, cardiology, and surgery, and subjects including brain mapping, neurochemistry, photomedicine, cardiovascular disease, and cancer.

项目摘要/摘要 我们请求资金升级大口径600 MHz磁共振光谱仪和显微成像仪的控制台， 位于马萨诸塞州总医院的阿蒂努拉·A·马蒂诺斯生物医学成像中心。这个 目前的系统是在2003年用NIH SIG奖励和机构支持的资金获得的 临床前医学成像区域共享资源的基本组成部分，并做出了贡献 为马蒂诺斯中心和当地的科学发现和技术创新做出了巨大贡献 调查人员。然而，经过十多年的服务，目前的系统已经过时了。它不仅是 与制造商新开发的用于尖端磁共振的功能和方法不兼容 光谱学和显微成像，但最可怕的是，制造商已经停止提供这方面的服务 由于技术的发展和缺乏过时的替换部件，老式仪器。 继续并加强其对马蒂诺斯中心成像双重使命的综合贡献 技术开发和床边翻译，这一600 MHz系统迫切需要 一次升级。我们请求资金来升级游戏机，包括其硬件和软件，并需要 并将使用其仍在工作的部件(磁铁和核磁共振探头等)。通过这件事 拟议升级，该系统具有高场、高分辨率、多核磁共振波谱和微 成像能力和最先进的技术将极大地有利于NIH提出的由 多样化的用户群体，包括来自12个主要用户和5个次要用户的17个项目。 通过这一SIG提出的升级得到了各级机构管理部门的支持， 从MGH领导层，到放射科和马提诺斯中心。这项支持涵盖所有 与升级及其未来业务有关的方面，包括仪器空间的分配和援助 对于安装、系统调度、记账和维护方面的运营支持，保证 从领导层那里获得额外的资金，如有必要，为意外短缺提供资金，最后，但大多数 值得注意的是，高达225,000美元的承诺用于弥补NIH SIG奖励和采购之间的缺口 升级的价格，以及MGH执行委员会承诺的100,000美元 对系统的维护进行了研究。升级后，600 MHz磁共振光谱仪和 具有温度控制能力(-80°C至200°C)的微型成像仪，由Martinos中心作为 共享核心，将在MGH和大波士顿提供给更广泛的研究社区 区域。和平倡议和咨询委员会将确保该系统公平和具有成本效益的运作，以 在推动有关一系列与医学相关的问题的新发现方面发挥重要作用 放射学、病理学、心脏病学和外科等领域，以及脑成像、神经化学、 光医学、心血管疾病和癌症。

项目成果

Screening human lung cancer with predictive models of serum magnetic resonance spectroscopy metabolomics.

• DOI: 10.1073/pnas.2110633118
• 发表时间: 2021-12-21
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Schult, Tjada A;Lauer, Mara J;Cheng, Leo L
• 通讯作者: Cheng, Leo L