Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
麻醉手术刺激下正常衰老和阿尔茨海默病的代谢组学特征
基本信息
- 批准号:10350570
- 负责人:
- 金额:$ 78.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-15 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:AD transgenic miceAftercareAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease diagnosisAlzheimer&aposs disease patientAnesthesia proceduresAnimal BehaviorAnimal ModelAnimalsAnti-Inflammatory AgentsBloodBrainBrain regionClinicClinicalClinical ProtocolsCyclosporineDevelopmentDiffusion Magnetic Resonance ImagingElectron MicroscopeEvaluationFoundationsFunctional Magnetic Resonance ImagingGluconeogenesisGlucoseGoalsHomeostasisHourHumanImageImmunochemistryImpairmentIndividualInterventionKnock-outLabelLeadLongevityMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMetabolicMethodsMitochondriaMonitorMusOnset of illnessOperative Surgical ProceduresOrganPathogenesisPathway interactionsPatientsPredispositionPreventiveProceduresProtocols documentationRestSerumStimulusTechnologyTestingTimeTissue HarvestingTissuesTrainingTransgenic OrganismsTranslatingValidationVitamin K 2Wild Type Mousearmbasebehavior testbrain tissuecohortdesignin vivoin vivo imagingin vivo magnetic resonance spectroscopymetabolomicsmitochondrial dysfunctionmorris water mazemouse modelmultimodalitymyelinationneuroinflammationnoninvasive diagnosisnormal agingnovelsuccesstool
项目摘要
We propose to quantify aging- and AD-associated brain and blood metabolic changes through ex vivo and in
vivo multimodality MR measurements in mouse models after an AD-promoting stimuli, anesthesia-surgery,
with-or-without preventive, protective treatments. This approach recognizes that AD onset, pathogenesis and
progression must produce alterations in the overall metabolic status, or metabolomics, of brain and other
organs in AD patients, as compared with normal homeostasis in healthy individuals, and our understanding of
the urgent need to develop non-invasive AD diagnosis tools. In the three proposed Aims, we will (1)
Characterize age-associated metabolomic changes ex vivo using tissues from different brain regions and blood
serum obtained from wild-type and AD mice after administration of anesthesia-surgery stimuli; (2) Develop
multimodality in vivo MR protocols for non-invasive evaluations of age- and AD-associated brain metabolic
changes induced by anesthesia-surgery stimuli; and (3) Investigate the effect of an AD protective intervention
on metabolomic changes after administration of anesthesia-surgery stimuli. The success of this project will
lead us to establish translational protocols that can guide and interpret multimodality in vivo MR imaging results
by obtaining accurate ex vivo MRS, EM, and immunochemistry measurements in the proposed animal models,
and translating these findings into clinical protocols for human AD non-invasive diagnosis.
我们建议通过体外和体内实验来量化衰老和AD相关的大脑和血液代谢变化。
在AD促进刺激,麻醉手术,
不管有没有预防性保护性治疗这种方法认识到AD的发病、发病机制和
疾病的进展必然会导致大脑和其他组织的整体代谢状态或代谢组学的改变。
与健康个体的正常稳态相比,我们对AD患者的器官的了解
迫切需要开发非侵入性AD诊断工具。在这三个目标中,我们将(1)
使用来自不同脑区和血液的组织离体表征年龄相关的代谢组学变化
在给予麻醉-手术刺激后从野生型和AD小鼠获得的血清;(2)开发
用于年龄和AD相关脑代谢非侵入性评价的多模态体内MR方案
麻醉-手术刺激引起的变化;(3)研究AD保护性干预的效果
对麻醉手术刺激后代谢组学变化的影响。该项目的成功将
引导我们建立可以指导和解释多模态体内MR成像结果的翻译协议
通过在所提出的动物模型中获得精确的离体MRS、EM和免疫化学测量,
并将这些发现转化为人类AD非侵入性诊断的临床方案。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Leo L Cheng其他文献
Leo L Cheng的其他文献
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{{ truncateString('Leo L Cheng', 18)}}的其他基金
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
麻醉手术刺激下正常衰老和阿尔茨海默病的代谢组学特征
- 批准号:
10556362 - 财政年份:2021
- 资助金额:
$ 78.67万 - 项目类别:
Upgrade of Console for 600 MHz MR Spectrometer
600 MHz 磁共振波谱仪控制台升级
- 批准号:
9272595 - 财政年份:2017
- 资助金额:
$ 78.67万 - 项目类别:
Development of Metabolomic and Molecular Probes for Prostate Cancer Assessment
用于前列腺癌评估的代谢组学和分子探针的开发
- 批准号:
8205493 - 财政年份:2011
- 资助金额:
$ 78.67万 - 项目类别:
Development of Metabolomic and Molecular Probes for Prostate Cancer Assessment
用于前列腺癌评估的代谢组学和分子探针的开发
- 批准号:
8332771 - 财政年份:2011
- 资助金额:
$ 78.67万 - 项目类别:
Detection of Lung Cancer Risks for Serum Metabolomics
血清代谢组学检测肺癌风险
- 批准号:
7787700 - 财政年份:2010
- 资助金额:
$ 78.67万 - 项目类别:
Detection of Lung Cancer Risks for Serum Metabolomics
血清代谢组学检测肺癌风险
- 批准号:
8010636 - 财政年份:2010
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
7914796 - 财政年份:2009
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
8530894 - 财政年份:2006
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
7893739 - 财政年份:2006
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
9248210 - 财政年份:2006
- 资助金额:
$ 78.67万 - 项目类别:
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