Disorders of Syntactic Comprehension

句法理解障碍

• 批准号: 7850346
• 负责人: David Norman Caplan
• 金额: $ 34万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850346
• 关键词: Accounting; Affect; Aphasia; Area; Behavioral; Brain; Brain Part; Brain region; Complex; Comprehension; Data; Disease; Hearing; Impairment; Individual; Lesion; Magnetic Resonance Imaging; Methods; Modems; Nature; Operative Surgical Procedures; Patients; Performance; Perfusion; Process; Research; Series; Short-Term Memory; Stroke; Structure; Testing; aphasic; base; lexical processing; neural model; phonology; processing speed; relating to nervous system; response; syntax

The long term objective of the research is to understand the nature of aphasic impairments in sentence comprehension, in particular the use of syntactic structure to determine sentence meaning, and the way the processes involved in sentence comprehension are organized in the brain. This project will examine aphasic patients with single strokes for their abilities to use differentsyntactic structures to determine aspects of sentence meaning, testing their use in a number of tasks. The result of these behavioral studies will be a detailed picture of what a patient can understand, and how s/he processes syntactic structures as s/he hears them (on-line processing) as well as when a sentence is over (off-line processing). We will obtain MR images of the structure and perfusion of regions of the patients' brains, and will identify the areas affected by the stroke, using modem analysis methods. Wewill then look for the brain regions in which lesion size accounts for significant amounts of the variance in performance. In the course of the research, we will provide data regarding both questions about the behavioral natureof sentence comprehension impairments (such as whether individual patients lose the ability to accomplish particular syntactic operations or whether their difficulties are best viewed as due to pathological limitations in their ability to accomplish operations in general, which affect more complex structures first), and about neural issues, such as whether aspects of the sentence comprehension process are always located in the same brain regions in all individuals. The results could have important consequences for howwe think of these disorders and the neural organization that supports these functions.

该研究的长期目标是了解句子失语症的本质 理解，特别是使用句法结构来确定句子含义，以及理解句子的方式 句子理解所涉及的过程是在大脑中组织的。该项目将检查失语症 单次中风患者能够使用不同的句法结构来确定中风的各个方面 句子的意思，测试它们在一些任务中的使用。这些行为研究的结果将是 患者能够理解的内容以及他/她如何处理所听到的句法结构的详细图片 它们（在线处理）以及句子结束时（离线处理）。我们将获得 MR 图像 患者大脑区域的结构和灌注，并将识别受影响的区域 中风，使用现代分析方法。然后我们将寻找病变大小所占的大脑区域 对于性能上的显着差异。在研究过程中，我们将提供数据 关于句子理解障碍的行为本质的两个问题（例如 个别患者是否失去了完成特定句法操作的能力，或者他们的 最好将困难视为由于他们完成行动的能力的病态限制。 一般，首先影响更复杂的结构），以及神经问题，例如是否 所有个体的句子理解过程总是位于相同的大脑区域。结果 可能会对我们如何看待这些疾病以及神经组织产生重要影响 支持这些功能。