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Exploring the Potential of Glia for Regulating Clinically Relevant Opiod Actions

探索神经胶质细胞调节临床相关阿片类药物作用的潜力

基本信息

批准号：
7768258
负责人：
LINDA WATKINS
金额：
$ 7.17万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-01 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7768258
关键词：
Adverse effects Analgesics Animal Welfare Astrocytes Bibliography Blood - brain barrier anatomy Brain Clinical Country Data Dependence Development Dose Drug usage Employee Strikes Environment Environmental Impact Equipment Exposure to Fibrinogen Goals IACUC International Investigation Knowledge Laboratories Mediating Microglia Morphine Morphine Dependence Naloxone Neuroglia Neurons Opiate Addiction Opioid Opioid Receptor Pain Pharmaceutical Preparations Physiological Play Principal Investigator Regulation Relative (related person)Research Research Ethics Committees Resources Rewards Role Spinal Spinal Cord Staging Stimulus Substance Withdrawal Syndrome Testing United States Up-Regulation Vertebrates Withdrawal abstracting addiction cell type clinically relevant cytokine drug craving expiration high risk human subject inhibitor/antagonist neurochemistry novel opioid abuse phrases prevent programs relating to nervous system

项目摘要

It has recently been discovered that glia become progressively more activated upon repeated exposure to morphine, & that this glial activation, in turn, modulates morphine's effects. This discovery was originally made in the context of studying the pain suppressive effects of morphine in spinal cord. The possibility that glia may be fundamentally important in determining the effects of opioids such as morphine is novel & important in its implications. Because of this, we propose to explore whether glia may profoundly alter the effects of repeated morphine in brain, as well. We believe that glia will prove to be powerfully involved in several phenomena currently thought to arise purely as a result of opioid effects on neurons; that is, dependence/withdrawal, reward & aversion. If this were true, it would provide evidence that glia are critically involved, not only in modulating the pain-suppressive effects of opioids, but also in

最近发现，神经胶质细胞在反复接触吗啡后变得越来越活跃，这种神经胶质细胞的激活反过来又调节了吗啡的作用。这一发现最初是在研究吗啡在脊髓中的疼痛抑制作用时发现的。胶质细胞在决定阿片类药物（如吗啡）的作用方面可能具有根本性的重要性，这种可能性是新颖的，其意义也是重要的。正因为如此，我们建议探索胶质细胞是否也会深刻地改变大脑中重复吗啡的作用。我们相信，胶质细胞将被证明是强大的参与几种现象，目前认为纯粹是由于阿片类药物对神经元的影响而产生的;即依赖/撤回，奖励和厌恶。如果这是真的，它将提供证据表明，胶质细胞不仅在调节阿片类药物的疼痛抑制作用中起着关键作用，而且在调节阿片类药物的疼痛抑制作用中也起着关键作用。