Strategic Vision & Impact on Environmental Health
战略愿景
基本信息
- 批准号:8055941
- 负责人:
- 金额:$ 23.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-04-01 至 2011-03-31
- 项目状态:已结题
- 来源:
- 关键词:AchievementAffectAreaBehaviorBiochemical PathwayBioinformaticsBiologicalBiological MarkersBiological PreservationBiologyBiomedical ResearchBiometryCancer Grant Supplements (P30)CardiologyCardiovascular DiseasesClinicalClinical MedicineCommunitiesCommunity IntegrationComplexComputational BiologyCountryCritical PathwaysDataData SetDevelopmentDiseaseDisease ProgressionEnvironmentEnvironmental HealthEnvironmental MedicineEnvironmental Risk FactorEpidemiologyFundingGene ProteinsGenesGeneticGenetic Crossing OverGenetic VariationGenomicsGoalsHealthHealth SciencesHumanInjuryInvestigationInvestmentsKnowledgeLifeMalignant NeoplasmsMass Spectrum AnalysisMediatingMessenger RNAMolecularMolecular BiologyMolecular GeneticsMolecular MedicineMolecular ProfilingNational Institute of Environmental Health SciencesPathogenesisPopulationProtein AnalysisProteomicsPublic HealthRecruitment ActivityResearchResearch ActivityResearch InfrastructureResearch PersonnelResearch SupportRoleSimulateSmall Interfering RNAStructureSystemSystems TheoryTalentsTechnologyThinkingTranslatingTranslationsUniversitiesVisionbasebench to bedsidecell growthclinical practiceenvironmental carcinogenesisgene environment interactionhuman diseaseimprovedinnovationmathematical modelmetabolomicsnovelprogramsprotein metaboliterepositoryresponse
项目摘要
Strategic Vision and Impact on Environmental Health
A. Overview
Environmental genomics focuses on the study of the gene-gene and gene-environment interactions that
mediate many of the complex diseases affecting human populations in today's world. This field combines the
knowledge derived from modern human and molecular genetics with studies of mRNA, protein and metabolite
profiling to understand how genes and genetic variations interact with environmental factors to cause disease.
Integrative biology is a closely related field focused on the application of systems theory to the study of
biological behavior and pathways critical to the preservation of health or the onset and progression of disease.
Advances in the fields of environmental genomics and integrative biology during the past five years have been
fueled by the need to translate molecular knowledge into concepts that impact our day-to-day lives and that
improve the practice of environmental medicine and public health. To this end, University of Louisville (UofL)
researchers have implemented academic and research programs in the areas of genetics and molecular
medicine leading to the development of a strong infrastructure in DMA sequencing technologies, siRNA
repositories, transcriptional profiling, mass-spectrometry (MS)-based protein analysis and proteomics, NMRand
MS-based metabolomics, and more recently, bioinformatics.
The establishment of a federally-funded Center for Environmental Genomics and Integrative Biology (CEGIB)
at UofL will help environmental health researchers with the management and interpretation of data emerging
from 'omic technologies and facilitate translation of these findings to public health and clinical practice. Full
realization of the benefits offered by molecular understanding of gene, protein and metabolite expression
profiles, the molecular circuitry that integrates the biological response to environmental injury, and the
identification of novel biomarkers of disease, will require strong infrastructure support in the areas of
bioinformatics, biostatistics, computational biology and bench-to-bedside or bench-to-community integration.
In this application, we seek funding to create a National Institute of Environmental Health Sciences (NIEHS)
Core Center at UofL that focuses on the application of genomics and integrative biology to problems in
environmental health. The UofL Center will promote scientific achievements that advance our molecular
understanding of human diseases and the role of environmental factors in the pathogenesis of disorders of
cellular growth and differentiation. The thematic areas of scientific focus at UofL are environmental
cardiology, environmental carcinogenesis and developmental origins of health and disease. These
NIEHS-funded areas of scientific activity are ripe for continued expansion and will be greatly facilitated by the
centralized infrastructure promoted by CEGIB. NIEHS investments at UofL will be leveraged by outstanding
institutional commitments to continue support of core functions in transcriptional profiling, proteomics and
metabolomics and to establish clinical and epidemiological research centers. Concerted efforts over the next
four years will be directed at the integration of disparate datasets to identify gene, protein and metabolite
networks, the development of mathematical models to simulate and predict biological behavior, and the
establishment of productive partnerships between basic and clinical researchers that advance research
findings in environmental genomics from the bench to the bedside. These efforts will help UofL environmental
health science investigators remain competitive and at the cutting edge of biomedical research.
Biological complexity is perhaps nothing more than a reflection of the complexities inherent to the natural
world. If environmental health researchers are to sustain their impact in advancing the biomedical research
agenda in this country, an integrated way of thinking that "marries" molecular biology to the higher levels of
biological organization needs to be nurtured and cultivated among the environmental health research
community. In this context, it is important to recognize that systems level thinking in environmental genomics
is not restricted to biomedical questions, but that it crosses over to the domains of clinical medicine and public
health. Indeed, realization of the potential of 'omic technologies will require creation of structures that support
the research enterprise and advance translation of molecular findings to practice. The team of UofL
researchers assembled in this application can contribute in meaningful ways to this goal.
对环境健康的战略愿景和影响
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kenneth S. Ramos其他文献
Health equity innovation in precision medicine: data stewardship and agency to expand representation in clinicogenomics
- DOI:
10.1186/s12961-024-01258-9 - 发表时间:
2024-12-19 - 期刊:
- 影响因子:3.200
- 作者:
Patrick J. Silva;Vasiliki Rahimzadeh;Reid Powell;Junaid Husain;Scott Grossman;Adam Hansen;Jennifer Hinkel;Rafael Rosengarten;Marcia G. Ory;Kenneth S. Ramos - 通讯作者:
Kenneth S. Ramos
Rabbit aortic smooth muscle cell culture. A model for the pharmacological study of diabetes-induced alterations in cell proliferation.
兔主动脉平滑肌细胞培养。
- DOI:
10.1016/0160-5402(91)90045-7 - 发表时间:
1991 - 期刊:
- 影响因子:0
- 作者:
C. Alipui;T. Tenner;Kenneth S. Ramos - 通讯作者:
Kenneth S. Ramos
Transcriptional Profiling and Functional Genomics Reveal a Role for AHR Transcription Factor in Nephrogenesis
转录谱和功能基因组学揭示 AHR 转录因子在肾发生中的作用
- DOI:
10.1196/annals.1371.045 - 发表时间:
2006 - 期刊:
- 影响因子:5.2
- 作者:
Kenneth S. Ramos - 通讯作者:
Kenneth S. Ramos
Osteopontin mRNA Expression in a Chemically‐Induced Model of Atherogenesis
化学诱导动脉粥样硬化模型中骨桥蛋白 mRNA 的表达
- DOI:
- 发表时间:
1995 - 期刊:
- 影响因子:5.2
- 作者:
A. Parrish;Kenneth S. Ramos - 通讯作者:
Kenneth S. Ramos
Allylamine enhances c-Ha-ras protooncogene expression in rat aortic smooth muscle cells.
烯丙胺增强大鼠主动脉平滑肌细胞中 c-Ha-ras 原癌基因的表达。
- DOI:
10.1016/0378-4274(93)90007-k - 发表时间:
1993 - 期刊:
- 影响因子:3.5
- 作者:
R. C. Bowes;Kenneth S. Ramos - 通讯作者:
Kenneth S. Ramos
Kenneth S. Ramos的其他文献
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{{ truncateString('Kenneth S. Ramos', 18)}}的其他基金
Functional Genomics of LINE-1 Retrotransposition
LINE-1 逆转录转座的功能基因组学
- 批准号:
10612492 - 财政年份:2022
- 资助金额:
$ 23.42万 - 项目类别:
Functional Genomics of LINE-1 Retrotransposition
LINE-1 逆转录转座的功能基因组学
- 批准号:
10337555 - 财政年份:2022
- 资助金额:
$ 23.42万 - 项目类别:
Role of Retroelements in Environmental Atherogenesis
逆转录因子在环境动脉粥样硬化形成中的作用
- 批准号:
7740689 - 财政年份:2009
- 资助金额:
$ 23.42万 - 项目类别:
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