Support for the recruit of a tenure track faculty member, Lie Gao, M.D., Ph.D.

描述（由申请人提供）：此P30申请是对RFA-OD-09-005的响应。高列博士将被内布拉斯加大学医学中心（UNMC）细胞与综合生理学系（CIP）聘为终身助理教授，现申请50万美元/年的工资支持和启动资金。在过去的40年里，CIP一直专注于心血管和肾脏生理学。在1989年Irving Zucker博士成为董事长后，心血管生理学在战略招聘和获得计划项目资助后变得更加突出，以研究慢性心力衰竭循环的神经控制。高博士从研究助理教授的职位上被招募，这是该机构对终身教职助理教授的特殊任命，将有助于心血管和肾脏生理学的战略招聘。高博士将为我们的团队带来他评估大鼠和小鼠交感神经功能的能力以及他在心力衰竭动物的中央记录方面的专业知识。他的腺病毒转染实验将为血管紧张素II受体在心力衰竭交感神经兴奋过程中的作用提供重要的新数据。他的实验将围绕脑干和下丘脑自主调节区域血管紧张素受体的调节区域展开。在这些研究中，他将特别关注血管紧张素2型受体。目前，他的工作正在太空中进行，使用的是祖克博士的设备。为了实现独立，他需要自己的空间和设备。UNMC将在本P30项目完成后为高博士提供两年的工资支持。CIP部将为高博士提供自己的实验室和办公场所。所有的资源都在UNMC和CIP中存在，以最大限度地提高他的研究成功的可能性。

DESCRIPTION (provided by applicant): This P30 application Is in response to RFA-OD-09-005. We request approximately $500,000/year for salary support and startup funds to elevate Dr. Lie Gao to a tenure track Assistant Professor in the Department of Cellular and Integrative Physiology (CIP) at the University of Nebraska IVIedical Center (UNMC). CIP has had a focus of cardiovascular and renal physiology for the past 40 years. Upon Dr. Irving Zucker becoming Chairman in 1989 cardiovascular physiology became even more prominent following strategic recruitments and the acquisition of a Program Project Grant to study the neural control of the circulation in chronic heart failure. The recruitment of Dr. Gao from a Research Assistant Professor, which is a special appointment at this institution to an Assistant Professor on the Tenure Track will contribute to the strategic recruitments in cardiovascular and renal physiology. Dr. Gao will bring specific expertise to our group in his ability to evaluate sympathetic function in rats and mice and his expertise at central recording in animals with heart failure. His adenoviral transfection experiments will provide important new data on the contribution of Angiotensin II receptors to the sympatho-excitatory process in heart failure. His experiments will revolve around the area of the regulation of angiotensin receptors in the autonomic regulatory areas in the brain stem and hypothalamus. He will especially focus on the Angiotensin Type 2 receptor in these studies. Currently, his work is being carried out in space and with equipment that belongs to Dr. Zucker. In order to achieve independence he will need his own space and equipment. UNMC will provide support for Dr. Gao's salary for 2 years following the completion of this P30. The Department of CIP will provide Dr. Gao with his own laboratory and office space. All the resources exist at UNMC and in CIP to maximize the likelihood of success in his research. Support for the recruitment of a tenure track faculty member, Lie Gao, M.D., Ph.D. for salary support and startup funds to elevate Dr. Lie Gao to a tenure track Assistant Professor in the Department of Cellular and Integrative Physiology (CIP) at the University of Nebraska Medical Center (UNMC).