The Role of Viruses in Human Cancer

描述（由申请人提供）：我们诚聘一名优秀的初级科学家担任终身助教，以扩大和加强我们在肿瘤病毒学方面的核心研究。迄今为止，特定的人类肿瘤病毒与至少15-20%的人类癌症有因果关系，并被广泛怀疑与其他癌症有关。我们已经确定了三个重要的研究领域：病毒免疫学（包括先天免疫和疫苗开发），病毒复制和肿瘤发生的系统生物学分析，以及抗病毒治疗。这笔拨款的批准将触发威斯康星大学麦迪逊分校的两个世界知名研究中心，分子病毒学研究所（IMV）和麦卡德尔癌症研究实验室（McArdle）之间建立一个新的联合职位，其中麦卡德尔提供正式的终身职位，而IMV提供实验室/办公空间以及额外的物理和行政资源。招聘工作将在积极的资助决定后立即开始，并将遵循我们传统的、严格的选拔程序，这些程序多年来在确定和招聘优秀的年轻教师方面被证明是成功的。作为这项拨款的一个关键目标，我们也将重点招聘一名初级女性和/或少数民族教员，与NIH的目标一致。与其他IMV/McArdle教员一样，新聘人员将被整合到这两个研究中心提供的病毒学核心人员中。此外，新员工将成为校园研究生项目、保罗·p·卡波恩综合癌症中心（UWCCC）和威斯康星传染病中心的一员。一如既往，我们的政策是为所有新聘用的教师提供广泛的个人指导，这是由5名高度参与的资深教师组成的实际指导委员会协调的。我们的年轻教师在前2-3年受到高度保护，不会承担大量的教学、行政或委员会服务承诺，让他们有时间专注于新的独立职位，并将他们的研究建立在受人尊敬的、富有成效的世界级项目上。我们有多种机制来评估这个项目对我们开展多学科研究能力的影响。

DESCRIPTION (provided by applicant): We propose to recruit an outstanding junior scientist as a tenure track assistant professor to augment and strengthen our core center In tumor virology. To date, specific human tumor viruses have been causally associated with at least 15-20% of all human cancers and are widely suspected to contribute to additional cancers. We have identified three research areas as critical program needs: viral immunology (including Innate immunity and vaccine development), systems biology analysis of viral replication and oncogenesis, and antiviral therapeutics. Approval of this grant would trigger the creation of a new joint position between two world-renowned research centers at the University of Wisconsin-Madison, the Institute for Molecular Virology (IMV) and the McArdle Laboratory for Cancer Research (McArdle), with McArdle providing the official tenure home and IMV providing laboratory/office space and additional physical and administrative resources. Recruitment efforts would begin immediately after a positive funding decision and would follow our traditional, rigorous selection processes that have proven successful over many years in identifying and recruiting outstanding young faculty. As a key objective of this grant, we also would focus the recruitment on a junior woman and/or minority faculty member, consistent with the NIH goals. As with other IMV/McArdle faculty, the new hire would be integrated within the staff of the virology core provided by these two research centers. In addition, the new hire would become a member of campus-wide graduate programs, the Paul P. Carbone Comprehensive Cancer Center (UWCCC) and the Wisconsin Center for Infectious Disease. As has always been our policy all new faculty hires are provided extensive personal mentoring that is coordinated through a hands-on mentoring committee of 5 highly-involved senior faculty. Our young faculty are highly protected in their first 2-3 years from extensive teaching and administrative or committee service commitments to allow them time to focus on their new independent positions, and to establish their research into respected, productive world-class programs. Multiple mechanisms are in place for evaluating the impact of this program on our capability to conduct multidisciplinary research.