Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses

功能性和功能失调的人类 CD4 T 细胞和 B 细胞对细菌和病毒的反应

• 批准号: 10285994
• 负责人: Shane P Crotty
• 金额: $ 126.39万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-17 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285994
• 关键词: 2019-nCoV; Address; B-Lymphocytes; Bacteria; CD4 Positive T Lymphocytes; COVID-19; COVID-19 pandemic; COVID-19 severity; Clinical; Common Cold; Contracts; Coronavirus Infections; Human; Immune; Individual; Infection; Longitudinal Studies; Measurement; Politics; Reporting; Risk; Role; SARS-CoV-2 infection; T cell response; T memory cell; Viral Load result; Virus; cohort; experimental study; memory CD4 T lymphocyte; response

PROJECT SUMMARY Pre-existing T cell memory to SARS-CoV-2 is detectable in ~50% of people. We first reported this, and we have since shown that this may largely be due to crossreactive memory CD4+ T cells from common cold coronavirus (CCC) infections. While this observation has been reproduced on three continents, the big unanswered question is whether these crossreactive memory T cells (i) confer some form of protection against COVID-19 disease severity, (ii) have no impact on COVID-19 severity, or (iii) increase COVID-19 disease severity. This issue has been widely discussed in scientific, public, and political spheres, and it potentially has major ramifications for understanding the COVID-19 pandemic. The direct experiment to address this topic is a longitudinal study of uninfected individuals at risk for acquisition of SARS-CoV-2, then assessing COVID-19 disease severity in individuals who contract SARS-CoV-2 infection, stratified between individuals who did or did not have pre- existing T cell memory to SARS-CoV-2.

项目总结