The Role of Viruses in Human Cancer

病毒在人类癌症中的作用

• 批准号: 7859417
• 负责人: F. Michael Hoffmann
• 金额: $ 36.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7859417
• 关键词: Antiviral Agents; Area; Communicable Diseases; Comprehensive Cancer Center; Educational process of instructing; Faculty; Funding; Goals; Grant; Hand; Heart; Home environment; Human; Immunology; Institutes; Interdisciplinary Study; Joints; Laboratories; Maintenance; Malignant Neoplasms; McArdle Laboratory for Cancer Research; Mentors; Minority; Molecular Virology; Natural Immunity; Oncogenic Viruses; Policies; Positioning Attribute; Process; Recruitment Activity; Research; Resources; Role; Scientist; Services; Systems Biology; Therapeutic; Time; Tumor Virus Infections; United States National Institutes of Health; Universities; Viral; Viral Genes; Virus; Virus Replication; Wisconsin; Woman; gene function; member; prevent; professor; programs; tumor; tumorigenesis; vaccine development; virology

DESCRIPTION (provided by applicant): We propose to recruit an outstanding junior scientist as a tenure track assistant professor to augment and strengthen our core center In tumor virology. To date, specific human tumor viruses have been causally associated with at least 15-20% of all human cancers and are widely suspected to contribute to additional cancers. We have identified three research areas as critical program needs: viral immunology (including Innate immunity and vaccine development), systems biology analysis of viral replication and oncogenesis, and antiviral therapeutics. Approval of this grant would trigger the creation of a new joint position between two world-renowned research centers at the University of Wisconsin-Madison, the Institute for Molecular Virology (IMV) and the McArdle Laboratory for Cancer Research (McArdle), with McArdle providing the official tenure home and IMV providing laboratory/office space and additional physical and administrative resources. Recruitment efforts would begin immediately after a positive funding decision and would follow our traditional, rigorous selection processes that have proven successful over many years in identifying and recruiting outstanding young faculty. As a key objective of this grant, we also would focus the recruitment on a junior woman and/or minority faculty member, consistent with the NIH goals. As with other IMV/McArdle faculty, the new hire would be integrated within the staff of the virology core provided by these two research centers. In addition, the new hire would become a member of campus-wide graduate programs, the Paul P. Carbone Comprehensive Cancer Center (UWCCC) and the Wisconsin Center for Infectious Disease. As has always been our policy all new faculty hires are provided extensive personal mentoring that is coordinated through a hands-on mentoring committee of 5 highly-involved senior faculty. Our young faculty are highly protected in their first 2-3 years from extensive teaching and administrative or committee service commitments to allow them time to focus on their new independent positions, and to establish their research into respected, productive world-class programs. Multiple mechanisms are in place for evaluating the impact of this program on our capability to conduct multidisciplinary research.

描述（由申请人提供）：我们建议招聘一位杰出的年轻科学家作为终身助理教授，以扩大和加强我们的肿瘤病毒学核心中心。迄今为止，特定的人类肿瘤病毒与至少15 - 20%的人类癌症有因果关系，并被广泛怀疑会导致其他癌症。我们已经确定了三个研究领域作为关键的计划需求：病毒免疫学（包括先天免疫和疫苗开发），病毒复制和肿瘤发生的系统生物学分析，以及抗病毒治疗。批准这笔赠款将触发威斯康星大学麦迪逊分校两个世界知名的研究中心，分子病毒学研究所（IMV）和麦卡德尔癌症研究实验室（McArdle）之间建立一个新的联合职位，McArdle提供官方任期，IMV提供实验室/办公空间以及额外的物理和行政资源。招聘工作将开始后，立即积极的资金决定，并将遵循我们的传统，严格的选拔程序，已被证明是成功的，多年来在确定和招聘优秀的年轻教师。作为这笔赠款的一个关键目标，我们还将重点招聘一名初级妇女和/或少数民族教师，与NIH的目标一致。与IMV/McArdle的其他教师一样，新员工将被整合到这两个研究中心提供的病毒学核心的工作人员中。此外，新员工将成为校园范围内的研究生课程，保罗P.卡伯恩综合癌症中心（UWCCC）和威斯康星州传染病中心的成员。与我们的一贯政策一样，所有新聘用的教师都将获得广泛的个人指导，并通过由5名高度参与的高级教师组成的亲力亲为的指导委员会进行协调。我们的年轻教师在他们的前2 - 3年从广泛的教学和行政或委员会服务承诺高度保护，让他们有时间专注于他们的新的独立职位，并建立他们的研究到受人尊敬的，富有成效的世界级计划。我们有多种机制来评估该计划对我们进行多学科研究的能力的影响。