UCLA Center for Excellence in Pancreatic Diseases

描述(由申请人提供)：加州大学洛杉矶分校胰腺疾病卓越中心是一个高度协作的多学科研究项目，旨在对胰腺疾病预防和治疗中的免费和替代医学的研究产生重大影响。植物性药物和膳食补充剂治疗胰腺疾病的生物学机制及代谢表型特征 作为对特定植物营养素的反应，可以形成以生物为基础的预防实践的理论基础 和治疗胰腺疾病。我们的中心包括加州大学洛杉矶分校生物医学分校的专业知识 港湾-加州大学洛杉矶分校医疗中心研究所和弗吉尼亚州大洛杉矶医疗系统-WEST 洛杉矶(VAGLAHS-WLA)。该中心由经验丰富的胰腺疾病研究人员领导，他们 组织调查小组开发高度互动和协同的研究方案。我们的目标是 研究植物营养素在炎症性和增生性疾病中的作用机制。 我们将在胰腺中使用分子生物学和代谢组学技术来研究改变的细胞 功能。可以测量对特定植物营养素反应的代谢表型的特征 通过示踪代谢组学。这些科学计划将研究药物的作用机制 利用这两种分子在胰腺炎性和增生性疾病中的植物营养素 生物工具和代谢组学技术。这些项目将侧重于：项目1-- 胰腺疾病中的植物化学物质和代谢，项目2--多酚在调节血脂中的作用 胰腺癌的炎症过程和项目3--黄酮类化合物对胰腺的影响 癌变和血管生成。这些项目将利用我们共享的核心资源，包括 管理核心、动物模型核心、植物营养核心和新陈代谢核心。行政部门 核心包括一个生物统计分核心，为所有研究项目和核心提供生物统计支持 中心的职能，以及研究和共享数据职能的管理。我们还计划 选择一个由国内和国际公认的翻译人员组成的外部咨询委员会 胰腺疾病研究人员。加州大学洛杉矶分校卓越中心旨在最大限度地整合和 多年来一直合作的关键调查人员的研究协同作用，使该中心能够 专注于最有前途、最具翻译潜力的NCCAM研究。

DESCRIPTION (provided by applicant): The UCLA Center for Excellence in Pancreatic Diseases constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of complimentary and alternative medicine in the prevention and therapy of pancreatic diseases. Biological mechanisms of action of botanicals and dietary supplements on pancreatic diseases and characterization of metabolic phenotypes in response to specific phytonutrients can form the rationale for biologically-based practices in the prevention and treatment of pancreatic diseases. Our Center includes expertise from the UCLA campus, LA BioMed Research Institute at Harbor-UCLA Medical Center, and VA Greater Los Angeles Healthcare System-West Los Angeles (VAGLAHS-WLA). The Center is led by experienced pancreatic disease researchers who have organized investigative teams to develop highly interactive and synergistic research programs. Our goal is to study the phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas in which we will use molecular biology and metabolomic technology to investigate altered cellular function. Characterization of metabolic phenotypes in response to specific phytonutrients can be measured by tracer metabolomics. These scientific programs will investigate the mechanisms of action of phytonutrients in both inflammatory and proliferative diseases of the pancreas utilizing both molecular biology tools and metabolomics technology. The projects will focus on: Project 1 - the effects of phytochemicals and metabolism in pancreatic diseases, Project 2 - role of polyphenols in regulating lipid inflammatory process in pancreatic cancer, and Project 3 - the effects of flavonoids on pancreatic carcinogenesis and angiogenesis. The projects will utilize our shared core resources including the Administrative Core, Animal Model Core, Phytonutrient Core, and Metabolomics Core. The Administrative Core includes a Biostatistics Sub-Core to provide biostatistical support to all the research projects and core functions, as well as the management of research and shared data functions of the Center. We also plan to select an External Advisory Board comprised of nationally and internationally recognized translational pancreatic disease researchers. The UCLA Center for Excellence is designed for maximum integration and synergy of research of key investigators who have been collaborating over the years so that the Center can be focused on the most promising investigations with the greatest NCCAM translational potential.