Administrative Core

行政核心

• 批准号: 8373951
• 负责人: Vay Liang W Go
• 金额: $ 15.13万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8373951
• 关键词: Advisory Committees; Alcohols; Animal Model; Animals; Area; Autophagocytosis; Biometry; Budgets; California; Collaborations; Computer software; Consultations; Core Facility; Data; Data Analyses; Development; Diet; Digestive System Disorders; Disease; Ensure; Fish Oils; Funding; Future; Goals; Grant; Head; Healthcare Systems; Inflammation; Institution; Instruction; Laboratory Animals; Liver; Los Angeles; Malignant neoplasm of pancreas; Manuscripts; Metformin; Methodology; Minority; Monitor; National Cancer Institute; National Center for Complementary and Alternative Medicine; National Institute on Alcohol Abuse and Alcoholism; Occupational activity of managing finances; Pancreatic Adenocarcinoma; Policies; Preparation; Prevention; Principal Investigator; Process; Program Research Project Grants; Progress Reports; Prostaglandins; Protocols documentation; Records; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Schedule; Services; Signal Transduction; Specific qualifier value; Woman; computerized data processing; daily functioning; data management; data sharing; design; gang; in vivo; information organization; meetings; member; professor; programs; symposium

instmctions); The Administrative Core will be responsible for overseeing the daily functions of the programs in fulfilling the goal of this program project grant. The Core will provide administrative support, including support for grants and financial management; scheduling of meetings and seminars; coordination of activifies between this POI and UCLA academic and administrative bodies, and the VA Greater Los Angeles Healthcare System-West Los Angeles. The Core will also provide biostatisfical support for all research projects and the management of research data and shared data function of the program. It will have the responsibility of managing details of the budget, appropriately filing budgetary informafion, and will file progress reports and communicate with NCI. The scheduling, dissemination of information, and organization of the program project Symposium, including the participafion of the External Advisory Board, and oversight all of the established policies for recruitment of women and minorities, and interacfion with other NCI programs will also be the responsibilities of the Administrative Core. The Administrative Core, under the direcfion of Dr. Vay Liang W. Go and Dr. Gang Li will provide biostatistical support: The research projects are: Project 1 investigates the importance of inflammation on diet-induced pancreatic cancer development and explores the role of prostaglandin signaling in this process, Project 2 explores in the intracellular signaling processes that are operafive in diet- induced pancreatic cancer development and the efficacy of fish oil (1) and metformin (2) in diet-induced pancreatic cancer development, Project 3 will examine the importance of autophagy, and Project 4 is the role of desmoplasia in diet-induced pancreatic cancer development. All projects are integrated and synergisfic and utilize two Cores, an Administrative (Core A) and Animal Core (Core B). The projects will also ufilize our shared core, including those at NCCAM funded UCLA Center for Excellence in Pancreafic Diseases, NDDK supported Digestive Disease Core Center, NIAAA funded Southern California Center for Alcohol Liver and Pancreafic Disease, other UCLA shared core resources in fulfilling the program project's goal in targeting diet-induced promotion of Kras-induced pancreatic cancer. RELEVANCE (See instructions): It is the Administrative Core's goal to provide the key management responsibilities to accomplish this program project's goal in investigafing the underiying mechanism in vivo animal model, to provide specific translational potential and future projects in the prevention and treatment of pancreatic cancer.

说明)； 行政核心将负责监督方案的日常职能，以履行 这项计划项目资助的目标。核心将提供行政支助，包括赠款支助。 和财务管理；安排会议和研讨会；协调本POI之间的活动 和加州大学洛杉矶分校的学术和行政机构，以及退伍军人事务部大洛杉矶医疗保健系统-West 洛杉矶。核心还将为所有研究项目和管理提供生物统计支持 研究数据和共享数据的程序功能。它将负责管理细节 预算，适当地提交预算信息，并将提交进度报告，并与 美国国家情报局。计划项目研讨会的日程安排、信息传播和组织， 包括外部咨询委员会的参与，并监督所有关于 招募妇女和少数民族，以及与其他NCI方案互动也将是责任 管理核心。行政核心，在魏良伟博士和郭伟强博士的指导下。 李刚将提供生物统计学支持：研究项目有：项目1调查 炎症在饮食诱导的胰腺癌发生中的作用及前列腺素的作用 在这个过程中，项目2探索了在饮食中操作的细胞内信号传递过程- 饮食诱导胰腺癌的发生及鱼油(1)和二甲双胍(2)的作用 胰腺癌的发展，项目3将检查自噬的重要性，项目4是 在饮食诱导的胰腺癌发展中的促结缔组织增生。所有项目都是集成和协同的 并利用两个核心，管理核心(核心A)和动物核心(核心B)。这些项目还将使我们的 共享核心，包括NCCAM资助的加州大学洛杉矶分校胰腺疾病卓越中心 支持消化疾病核心中心，NIAAA资助的南加州酒精肝脏和 胰腺疾病，其他加州大学洛杉矶分校共享核心资源，以实现该计划项目的目标 饮食诱导促进Kras诱导的胰腺癌。 相关性(请参阅说明)： 行政核心的目标是提供关键的管理责任来实现这一点 计划项目的目标是在活体动物模型中研究基础机制，为 胰腺癌预防和治疗中的翻译潜力和未来项目。