Animal Behavioral Phenotyping

该补充和替代医学卓越研究中心的总体目标 （CERC）在阿尔茨海默病中的应用是鉴定具有生物活性的葡萄衍生多酚在AD预防中的作用 在阿尔茨海默病型Ap神经病理学和认知功能障碍的Tg 2576小鼠模型中， 恶化该中心的整体研究活动将探索葡萄多酚 化合物对降低Tg 2576中阿尔茨海默病型认知恶化的潜在作用 小鼠通过减少可溶性细胞外寡聚物A|大脑中的三个物种基于此 考虑到，核心C（小鼠表型核心）的目的是直接支持整个中心 通过促进Tg 2576小鼠响应于以下治疗的认知功能的表征， 从葡萄汁/葡萄酒中提取的多酚制剂（项目1），葡萄衍生的多酚，白藜芦醇 （项目2）和葡萄籽提取物多酚制剂（项目3）。认识到， 认知和行为模式有助于高等动物的整体认知功能状态， 包括人类和AO小鼠模型，核心C将使用多种行为模式，以提供更多的 全面和敏感的措施，改变认知功能，响应多酚治疗。 因此，核心C的活动将把各个项目的具体目标与以下总体目标结合起来： 这种CERC在阿尔茨海默病中的应用。CERC在阿尔茨海默病方面的集体努力 将为开发葡萄多酚的单一或组合提供合理的依据 用于通过调节一种或多种AD相关的 机制等

The overall objective of this Center of Excellence for Research on Complementary and Alternative Medicine (CERC) in Alzheimer's disease application is to identify bioactive grape-derived polyhenols in AD prevention and/or therapy in the Tg2576 mouse model of Alzheimer's disease-type Ap neuropathology and cognitive deterioration. The overall research activities in this Center will explore grape-derived polyphenolic compounds for their potential roles of reduce Alzheimer's disease type cognitive deterioration in Tg2576 mice by reducing the accumulation of soluble extracellular oligomeric A|3 species in the brain. Based on this consideration, the purpose of Core C (Mouse Phenotyping Core) is to directly support the overall Center effort by facilitating the characterization of cognitive functions in Tg2576 mice in response to treatments with polyphenolic preparations from grape juice/wine (Project 1), the grape-derived polyphenolic, resveratrol (Project 2) and polyphenolic preparations from grape seed extract (Project 3). In recognition that multiple cognitive and behavioural modalities contribute to the overall cognitive functional status in higher animals, including human and AO mouse models, Core C will use multiple behavioural paradigms to provide a more comprehensive and sensitive measure of changes cognition function in response to polyphenolic treatments. Thus, the activity of Core C will integrate the specific goals of individual projects with the overall objective of this CERC in Alzheimer's disease application. The collective effort from the CERC in Alzheimer's disease will provide the rational basis for developing individual or a combination of grape-derived polyphenolic compounds for Alzheimer's disease prevention and/or therapy by modulating one or more of the AD-related mechanisms.