Energy Expenditure and Metabolic Control among T1D Youth

T1D 青少年的能量消耗和代谢控制

• 批准号: 8213981
• 负责人: RANDI STREISAND
• 金额: $ 8.44万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2013-03-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8213981
• 关键词: Address; Adherence; Adolescent; Aerobic; Affect; Aftercare; American; Area; Attention; Back; Behavior Therapy; Behavioral; Behavioral Research; Biometry; Blood Glucose; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Complex; Comprehensive Health Care; Data; Data Analyses; Diabetes Mellitus; Diabetes prevention; Diet; Disease; Disease Management; Energy Metabolism; Equilibrium; Exercise; Failure; Family; Female; Frequencies; Future; General Population; Goals; Health; Insulin; Insulin-Dependent Diabetes Mellitus; Intake; Intervention; Knowledge; Lead; Life; Light; Literature; Maximum Heart Rate; Measurement; Measures; Medical; Mentors; Metabolic; Metabolic Control; Methods; Monitor; National Children' s Study; Nature; Nutritional; Outcome; Parents; Patient Self-Report; Physical activity; Physiology; Positioning Attribute; Public Health; Public Health Practice; Quality of life; Recommendation; Regimen; Research; Risk; Role; Sampling; Science; Self Care; Teenagers; Time; Training; Universities; Ursidae Family; Washington; Youth; adverse outcome; base; biobehavior; blood glucose regulation; cardiovascular risk factor; diabetes control; diabetes management; epidemiologic data; evidence base; experience; fitness; follow-up; glucose monitor; knowledge base; meetings; nutrition; programs; protective effect; stem; tool

DESCRIPTION (provided by applicant): Type 1 diabetes is a lifelong illness that demands constant attention and management, requiring adhering to a complex, medically prescribed self-care regimen. Behavioral interventions to promote adherence in diabetes management in youth have largely focused on consistent blood glucose monitoring, and the role of physical activity has been inconsistently examined in relationship to metabolic outcomes. This is true despite regular physical activity being medically advised as part of comprehensive care planning, as supported by data from large, national studies of children's metabolic control. However, little is known about the specific nature and timing of the impact of levels on children's blood glucose regulation. Some indications of benefit include short- term changes in metabolic control and enhanced quality of life, balanced against the risks of low blood glucose levels that can accompany high energy expenditure. Though there are new and advanced measures and methods in exercise science that could be brought to bear in addressing these complex biobehavioral questions, this knowledge and expertise tends to reside outside of the clinical and behavioral research literature in childhood diabetes. By combining these tools for the assessment of physical activity and energy expenditure (i.e., the amount of energy used to perform a physical activity) with those that measure glycemic variability (i.e., excursions of blood glucose from low to high and back again), I plan to incorporate more informed physical activity recommendations into my behavioral interventions for youth with diabetes. I propose to do this by seeking mentored training experiences with Dr. Loretta DiPietro (an expert in exercise science) at The George Washington University, as well as by taking additional coursework at the University in exercise science methods and data analysis, biostatistics, and physiology. These are cornerstones of basic behavioral research in health, and hold promise in enriching my clinical research program and strengthening my capacity to meet the public health challenges associated with pediatric diabetes prevention and control. PUBLIC HEALTH RELEVANCE: The management of type 1 diabetes in children demands constant attention and careful adherence to a complex medical regimen, including monitoring of physical activity. However, behavioral interventions aimed to promote adherence in children with type 1 diabetes rarely include physical activity. By examining the relationship among energy expenditure and glycemic variability, we will gain a better understanding of the role of physical activity in diabetes management. Findings can lead to the inclusion of physical activity into future behaviorally based adherence promotion programs.

描述（由申请人提供）：1型糖尿病是一种终身疾病，需要持续关注和管理，需要坚持复杂的医学规定的自我护理方案。促进青少年糖尿病管理依从性的行为干预主要集中在持续的血糖监测上，而身体活动在与代谢结果的关系方面的作用一直没有得到一致的检验。这是事实，尽管有规律的体育活动被医学建议作为全面护理计划的一部分，这得到了大型国家儿童代谢控制研究数据的支持。然而，对儿童血糖调节水平影响的具体性质和时间知之甚少。一些有益的迹象包括代谢控制的短期变化和生活质量的提高，与伴随高能量消耗的低血糖水平的风险相平衡。尽管在运动科学中有新的和先进的措施和方法可以用来解决这些复杂的生物行为问题，但这些知识和专业知识往往存在于儿童糖尿病的临床和行为研究文献之外。通过将这些评估体力活动和能量消耗的工具（即，进行体力活动所消耗的能量）与测量血糖变异性的工具（即，血糖从低到高再到高的波动）相结合，我计划将更明智的体力活动建议纳入我对青少年糖尿病患者的行为干预中。我建议通过寻求乔治华盛顿大学Loretta DiPietro博士（运动科学专家）的指导训练经验，以及在大学里参加运动科学方法和数据分析、生物统计学和生理学方面的额外课程来做到这一点。这些都是健康基础行为研究的基石，有望丰富我的临床研究项目，增强我应对与儿童糖尿病预防和控制相关的公共卫生挑战的能力。