Does biogeography select for human disease patterns among Salmonella serovars

生物地理学是否选择沙门氏菌血清型中的人类疾病模式

• 批准号: 7940093
• 负责人: Sonia Hernandez-Divers
• 金额: $ 44.49万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-07 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7940093
• 关键词: Accounting; Address; Affect; Animal Diseases; Animals; Behavior; Biology; Blood Circulation; Cessation of life; Clinical; Complex; Country; Custom; Discipline; Disease; Disease Outbreaks; Ecology; Enteral; Environment; Environmental Microbiology; Epidemiology; Food; Genetic; Geographic Locations; Geography; Goals; Grant; Health; Hospitalization; Human; Incidence; Infection; Light; Link; Modeling; Natural History; Pattern; Physical environment; Population Density; Positioning Attribute; Prevalence; Province; Public Health; Pulsed-Field Gel Electrophoresis; Research; Research Personnel; Role; Salmonella; Salmonella enterica; Salmonella infections; Source; Southeastern United States; Stratification; Surface; United States; Veterinary Medicine; Water; Work; base; demographics; disease transmission; expectation; exposed human population; human disease; innovation; land use; novel; public health relevance; regional difference; transmission process; vector; water quality

DESCRIPTION (provided by applicant): The interplay of biology and behavior, and interactions between specific serovars, reservoir hosts, humans and the physical environment contributes to the transmission of Salmonella from non-food sources. The overall objective of this application is to establish the link between the environment and sporadic cases of salmonellosis. The central hypothesis is that unique environmental and ecological composition of a geographic region selects specific S. enterica serovars and influences human disease pattern(s). The following specific aims will be pursued: 1) compare Salmonella prevalence and serovar distribution in wildlife and the environment in distinct watersheds, and 2) identify the ecological/environmental parameters affecting the presence of specific serovars and strains among wildlife, waters and humans. The novel notion that landscape, land-use, demographics, and geography drive biogeographical patterns in Salmonella prevalence, serovar distribution and incidence of human cases will be explored through the examination of key watersheds for Salmonella carriage in wildlife, loading in surface waters, incidence of clinical human and animal disease and comparison of isolates between sources. This work will elucidate important ecological factors responsible for patterns in Salmonella serovar distribution and human disease, while providing an innovative approach to help understand the role of the environment in human enteric disease. PUBLIC HEALTH RELEVANCE: Despite continued efforts to reduce rates of Salmonella infection in the U.S., incidence remains much higher (16.2 cases/100,000) than the goal of 6.8 set for 2010 and certain regions of the country are disproportionately affected. This project aims to examine the unique environmental and ecological composition of a geographic region selects specific Salmonella enterica serovars and influences human disease patterns. This work will elucidate important ecological factors responsible for patterns in Salmonella serovar distribution and human disease, while providing an innovative approach to help understand the role of the environment in human enteric disease.

描述（由申请人提供）：生物学和行为的相互作用，以及特定血清型、储存宿主、人类和物理环境之间的相互作用，有助于沙门氏菌从非食物来源的传播。该应用的总体目标是建立环境与沙门氏菌病散发病例之间的联系。中心假设是地理区域独特的环境和生态组成选择了特定的肠沙门氏菌血清型并影响人类疾病模式。将追求以下具体目标：1）比较不同流域野生动物和环境中沙门氏菌的流行率和血清型分布，2）确定影响野生动物、水域和人类中特定血清型和菌株存在的生态/环境参数。通过检查野生动物中沙门氏菌携带的关键流域、地表水中的负荷、临床人类和动物疾病的发生率以及来源之间的分离株比较，将探索景观、土地利用、人口统计和地理驱动沙门氏菌流行、血清型分布和人类病例发病率的生物地理模式的新概念。这项工作将阐明导致沙门氏菌血清型分布和人类疾病模式的重要生态因素，同时提供一种创新方法来帮助了解环境在人类肠道疾病中的作用。 公共卫生相关性：尽管美国不断努力降低沙门氏菌感染率，但发病率（16.2 例/100,000 例）仍然远高于 2010 年设定的 6.8 例目标，而且该国某些地区受到的影响尤为严重。该项目旨在研究某个地理区域的独特环境和生态组成，选择特定的肠沙门氏菌血清型并影响人类疾病模式。这项工作将阐明导致沙门氏菌血清型分布和人类疾病模式的重要生态因素，同时提供一种创新方法来帮助了解环境在人类肠道疾病中的作用。

项目成果

Diversity and Persistence of Salmonella enterica Strains in Rural Landscapes in the Southeastern United States.

美国东南部乡村地区肠道沙门氏菌菌株的多样性和持久性。

• DOI: 10.1371/journal.pone.0128937
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Maurer,JohnJ;Martin,Gordon;Hernandez,Sonia;Cheng,Ying;Gerner-Smidt,Peter;Hise,KelleyB;TobinD'Angelo,Melissa;Cole,Dana;Sanchez,Susan;Madden,Marguerite;Valeika,Steven;Presotto,Andrea;Lipp,ErinK
• 通讯作者: Lipp,ErinK