Cell Death 2010 Gordon Research Conference

细胞死亡 2010 戈登研究会议

• 批准号: 7993820
• 负责人: John M Abrams
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7993820
• 关键词: Aftercare; Apoptosis; Area; Arts; Autophagocytosis; Cell Death; Cell Death Process; Cells; Development; Disease; Embryonic Development; Excision; Failure; Human body; Immune; Immune system; Lead; Life Expectancy; Malignant Neoplasms; Necrosis; Neurodegenerative Disorders; Pathology; Process; Radiation; Regulation; Research; Specific qualifier value; Therapeutic Intervention; Time; age related; brain cell; cancer cell; cancer therapy; carcinogenesis; novel strategies; public health relevance; symposium

DESCRIPTION (provided by applicant): Cell death contributes to many different processes, including (but not restricted to) the elimination of cells during normal embryo development, the maturation and functions of the immune system, and the removal of cancer cells after treatment with radiation or chemotherapeutics. Hence, a failure of appropriately timed cell death can lead to developmental abnormalities, immune deficiencies, and failure of cancer therapy. Excessive cell death underlies the pathology of many degenerative and age-related instances to carcinogenesis. Therefore, we are hopeful that detailed understanding of the cell death process (including apoptosis, necrosis and autophagy) will greatly enhance our ability to treat a wide range of pathological conditions, including neurodegenerative disorders and cancer. The 2010 Gordon Research Conference on Cell Death will promote free exchange of state-of-the-art unpublished scientific information, focusing on the mechanisms that specify the main distinct types of cell death. The conference should both accelerate discovery in the area and help to identify new approaches to for therapeutic intervention in many diseases that result from inappropriate regulation of cell death. PUBLIC HEALTH RELEVANCE: The human body contains cells with different life expectancies. Diseases are caused by either too much cell death such as with untimely brain cell death or too little cell death such as with the cell accumulation seen in cancer. The 2010 Gordon Research Conference on Cell Death will promote free exchange of state- of-the-art unpublished scientific information, focusing on the mechanisms that specify the main distinct types of cell death. The conference should both accelerate discovery in the area and help to identify new approaches for therapeutic intervention in the many diseases that result from inappropriate regulation of cell death.

描述（由申请人提供）：细胞死亡有助于许多不同的过程，包括（但不限于）正常胚胎发育期间细胞的消除，免疫系统的成熟和功能，以及放射或化疗治疗后癌细胞的清除。因此，适当时间的细胞死亡失败可能导致发育异常、免疫缺陷和癌症治疗失败。过度的细胞死亡是许多退行性和与年龄相关的癌变的病理基础。因此，我们希望对细胞死亡过程（包括细胞凋亡、坏死和自噬）的详细了解将大大提高我们治疗包括神经退行性疾病和癌症在内的各种病理状况的能力。2010年戈登细胞死亡研究会议将促进最新的尚未发表的科学信息的自由交流，重点是确定主要不同类型细胞死亡的机制。这次会议既应加速这一领域的发现，又应有助于确定对许多因细胞死亡调节不当而导致的疾病进行治疗干预的新方法。