Adipogenic and Metabolic Effects of Antipsychotic Drugs

描述(申请人提供)：抗精神病药物(APD)，特别是非典型抗精神病药物，是许多患者的治疗福音，也是最广泛使用的处方药之一。虽然许多APD具有许多优点，但在已经处于代谢脆弱状态的人群中，许多APD在促进肥胖、肥胖和代谢失调方面存在重大缺陷。过去十年见证了旨在量化、理解、预防和减轻这些不利影响的大量研究工作。本次会议的具体目的1是向与会者提供关于以下方面的全面的科学最新情况：(A)肥胖、糖尿病和其他代谢紊乱在典型的APDS患者群体中的严重程度和频率；(B)药物不良代谢影响的严重程度；(C)这些APD不良影响的生化和分子机制；(D)这些APD不良影响的行为和能量机制；(E)减少这些不良影响的治疗和预防策略的安全性和有效性；(F)这些APD引起的肥胖和新陈代谢改变对发病率、死亡率、生活质量、治疗依从性和保健费用的下游影响；以及(G)所涉及的统计和方法问题。具体目标2是通过促进来自不同学科的科学家之间的互动，促进新的跨学科和转化性研究，范围从基础工作台生物学家到临床医生和流行病学家。具体目标3是在我们的网站上向全球社区免费提供完整的会议录像。这次为期两天的会议将汇集来自不同学科的专家科学家，探讨有关APDS的代谢和成脂影响的未回答问题，并为未来的研究引入新的想法。 公共卫生相关性：抗精神病药物对许多患者来说是一个重要的治疗选择，但会导致严重的体重增加和代谢紊乱。本次会议将探讨原因和潜在的解决方案。

DESCRIPTION (provided by applicant): Antipsychotic drugs (APDs), and atypical antipsychotic drugs in particular, are a therapeutic boon for many patients and are among the most widely prescribed drugs. Though possessing many advantages, many APDs have a major liability in their ability to promote adiposity, obesity, and metabolic dysregulation in an already metabolically vulnerable population. The past decade has been witness to substantial research effort aimed at quantifying, understanding, preventing, and alleviating these adverse effects. Specific Aim 1 of this meeting is to provide participants a thorough state of science uddate regarding: (a) The magnitude and frequency of obesity, diabetes, and other metabolic disturbances among patient populations that typically receive APDs; (b) The magnitude of the adverse metabolic effects by drug; (c) Biochemical and molecular mechanisms of these adverse APD effects; (d) The behavioral and energetic mechanisms of these adverse APD effects; (e) The safety and efficacy of treatment and prevention strategies to reduce these adverse effects; (f) The down-stream effects of these APDinduced alterations in adiposity and metabolism on morbidity, mortality, quality of life,treatment adherence, and health care costs; and; (g) The statistical and methodological issues involved. Specific Aim 2 is to promote new interdisciplinary and translational research by facilitating interactions among scientists from different disciplines and ranging from basic bench biologists to clinicians and epidemiologists. Specific Aim 3 is to make complete videotaped proceedings freely available to the worldwide community on our website. This 2-day meeting will bring together expert scientists from diverse disciplines to explore unanswered questions about these the metabolic and adipogenic effects of APDs and to introduce novel thoughts for future research. PUBLIC HEALTH RELEVANCE: Antipsychotic drugs are an important therapeutic option for many patients, but can cause serious weight gains, and metabolic disregulations. This conference will explore the reasons why and the potential solutions.