Obesity and Longevity Across Generations
Obesity and Longevity Across Generations
批准号:
10177831
负责人:
DAVID B ALLISON
金额:
$27.65万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-01 至 2023-05-31
关键词:
AdultAffectAgingAnimal ModelBehavioralBiologyBirth WeightBody mass indexCharacteristicsCollectionComplexData SetDevelopmentDiabetes MellitusElderlyEnvironmentEnvironmental Risk FactorEpidemiologyExperimental ModelsFamilyFutureFuture GenerationsGenerationsGenetic Predisposition to DiseaseGenomeHealthHeart DiseasesHumanIndividualInterventionLeadLifeLife ExpectancyLongevityLow Birth Weight InfantModelingMultiple Birth OffspringObesityOutcomePersonsPhenotypePhysiologicalPopulationPopulation trendsPositioning AttributePredispositionPrevalencePrevention strategyPublic HealthPublic PolicyResearch PersonnelRiskSocietiesSociologyStigmatizationTestingTimeWeightWorkcohortcritical perioddevelopmental plasticitydeviantintergenerationallife historymortalitymultiple datasetsobesity riskoffspringoffspring obesitypopulation healthpreventive interventionreproductiverisk variantsocialsocial stigmasociodemographicssociologiststemtheories
中文摘要
父母和早期生活因素的变化是否会改变肥胖和长寿之间的关系?
英文摘要
Are changing distributions of parental and early life factors altering the relation between obesity and longevity?
Will the increasing prevalence of obesity in the US reverse recent gains in US life expectancy? What makes
some individuals more susceptible to the life-shortening effects of obesity than others? Answering these
questions requires a better understanding of the complex relations between obesity and longevity; in particular,
the potential for the early environment and related developmental factors to exert powerful modifying effects on
the association between obesity and longevity.
We test four interrelated hypotheses about how demographic changes in the distribution of body mass index
(BMI) may affect the current generation's lifespan and modify obesity's effect on lifespan in subsequent
generations. These hypotheses are built on findings from experimental model organisms and human
epidemiology, theories of life histories and developmental plasticity from evolutionary biology, and sociologic
frameworks for understanding both intergenerational change and the health consequences of obesity's stigma.
Relying on a large, rich, and complementary collection of secondary datasets, we will complete the following
aims: Aim 1 - Test the hypothesis that relative BMI position in one's generational or cohort BMI distribution
predicts longevity above and beyond one's absolute BMI. Aim 2 - Test the hypotheses that each of several
factors related to offspring development and BMI—parental BMI, offspring genome risk score for obesity
(BMIGP), and family common environment risk for obesity, exert transgenerational effects and predict (and
hence plausibly influence) offspring mortality rate independent of offspring BMI. Aim 3 - Test the hypotheses
that a “mismatch” between an offspring's physiological predisposition for a given level of obesity and actual
offspring obesity will be, all else being equal, associated with decreased longevity. This hypothesis draws on
the idea of adaptive developmental plasticity, in which individuals may be physiologically `calibrated' during
early development to achieve best function and longevity for a phenotype in later life that would be predicted
by their environmental and genetic predisposition during early development. Aim 4 - Estimate the extent to
which adjusting for changes in the distributions of parental BMI, offspring birth weight, and offspring BMIGP
accounts for secular changes in the BMI-longevity relation that have occurred in the last half century.
An interdisciplinary team of statisticians, aging researchers, obesity researchers, sociologists, geneticists, and
evolutionary and reproductive biologists has been carefully assembled for this work. Understanding how and
why obesity is associated with reduced longevity and who is most vulnerable to its health risks is vital to
informing public policies and anticipating population health needs. Further, identifying early life characteristics
and environmental conditions which exacerbate obesity's effects on health and longevity is vital to identifying
critical periods and populations where biomedical or behavioral preventive interventions can be most effective.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.ssmph.2022.101200
发表时间:
2022-09
期刊:
SSM-POPULATION HEALTH
影响因子:
4.7
作者:
[Pavela, Gregory, Yi, Nengjun, Mestre, Luis, Lartey, Stella, Xun, Pengcheng, Allison, David B.]
通讯作者:
Allison, David B.
Strengthening Causal Inference in Behavioral Obesity Research
-
批准号:9651880
-
项目类别:
-
资助金额:$14.14万
-
财政年份:2018
-
负责人:DAVID B ALLISON
-
依托单位:
Strengthening Causal Inference in Behavioral Obesity Research
-
批准号:9764709
-
项目类别:
-
资助金额:$19.93万
-
财政年份:2018
-
负责人:DAVID B ALLISON
-
依托单位:
Core E - Comparative Data Analytics Core
-
批准号:10044657
-
项目类别:
-
资助金额:$12.01万
-
财政年份:2015
-
负责人:DAVID B ALLISON
-
依托单位:
Core E - Comparative Data Analytics Core
-
批准号:10260430
-
项目类别:
-
资助金额:$11.82万
-
财政年份:2015
-
负责人:DAVID B ALLISON
-
依托单位:
Beyond textbook, yet simple, statistical tools for reproducible animal research
-
批准号:9142329
-
项目类别:
-
资助金额:$6.91万
-
财政年份:2015
-
负责人:DAVID B ALLISON
-
依托单位:
Core E - Comparative Data Analytics Core
-
批准号:10633299
-
项目类别:
-
资助金额:$14.16万
-
财政年份:2015
-
负责人:DAVID B ALLISON
-
依托单位:
Core E - Comparative Data Analytics Core
-
批准号:10461874
-
项目类别:
-
资助金额:$16.11万
-
财政年份:2015
-
负责人:DAVID B ALLISON
-
依托单位:
Core E: Comparative Data Analytics Core
-
批准号:8958642
-
项目类别:
-
资助金额:$8.67万
-
财政年份:2015
-
负责人:DAVID B ALLISON
-
依托单位:
Strengthening Causal Inference in Behavioral Obesity Research
-
批准号:10442511
-
项目类别:
-
资助金额:$20.59万
-
财政年份:2014
-
负责人:DAVID B ALLISON
-
依托单位:
Strengthening Causal Inference in Behavioral Obesity Research
-
批准号:9306177
-
项目类别:
-
资助金额:$5.79万
-
财政年份:2014
-
负责人:DAVID B ALLISON
-
依托单位:
Strengthening Causal Inference in Behavioral Obesity Research
-
批准号:10653986
-
项目类别:
-
资助金额:$20.82万
-
财政年份:2014
-
负责人:DAVID B ALLISON
-
依托单位:
Strengthening Causal Inference in Behavioral Obesity Research
-
批准号:8769557
-
项目类别:
-
资助金额:$20.47万
-
财政年份:2014
-
负责人:DAVID B ALLISON
-
依托单位:
Strengthening Causal Inference in Behavioral Obesity Research
-
批准号:10217227
-
项目类别:
-
资助金额:$21.04万
-
财政年份:2014
-
负责人:DAVID B ALLISON
-
依托单位:
Evaluating Bioactive Food Components in Obesity and Cancer Prevention
-
批准号:8459147
-
项目类别:
-
资助金额:$1.5万
-
财政年份:2013
-
负责人:DAVID B ALLISON
-
依托单位:
The Mathematical Sciences in Obesity Research
-
批准号:10602417
-
项目类别:
-
资助金额:$10.8万
-
财政年份:2013
-
负责人:DAVID B ALLISON
-
依托单位:
The Mathematical Sciences in Obesity Research
-
批准号:9086367
-
项目类别:
-
资助金额:$10.82万
-
财政年份:2013
-
负责人:DAVID B ALLISON
-
依托单位:
The Mathematical Sciences in Obesity Research
-
批准号:8853277
-
项目类别:
-
资助金额:$10.89万
-
财政年份:2013
-
负责人:DAVID B ALLISON
-
依托单位:
The Mathematical Sciences in Obesity Research
-
批准号:10368960
-
项目类别:
-
资助金额:$10.8万
-
财政年份:2013
-
负责人:DAVID B ALLISON
-
依托单位:
The Mathematical Sciences in Obesity Research
-
批准号:8549549
-
项目类别:
-
资助金额:$10.95万
-
财政年份:2013
-
负责人:DAVID B ALLISON
-
依托单位:
The Mathematical Sciences in Obesity Research
-
批准号:8675851
-
项目类别:
-
资助金额:$10.95万
-
财政年份:2013
-
负责人:DAVID B ALLISON
-
依托单位:
海外基金