Beyond textbook, yet simple, statistical tools for reproducible animal research

超越教科书的简单统计工具，用于可重复的动物研究

• 批准号: 9142329
• 负责人: DAVID B ALLISON
• 金额: $ 6.91万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-10 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9142329
• 关键词: Address; Advocate; American; Animal Experimentation; Animals; Basic Science; Biometry; Characteristics; Collaborations; Communication; Communities; Complex; Consult; Country; Crossover Design; Data; Education; Educational Materials; Educational process of instructing; Equation; Evaluation; Experimental Designs; Face; Failure; Fostering; Health; Human; Human Resources; Immersion Investigative Technique; Intervention; Investigation; Knowledge; Laboratories; Laboratory Animals; Laboratory Research; Laboratory Scientists; Learning; Measures; Methods; Mission; Modeling; National Institute of General Medical Sciences; Natural Sciences; Paper; Postdoctoral Fellow; Procedures; Protocols documentation; Publishing; Randomized; Reading; Recommendation; Reproducibility; Research; Research Design; Research Misconduct; Research Personnel; Resources; Science; Scientist; Self Assessment; Statistical Data Interpretation; Testing; Textbooks; Training; Training Activity; Translating; Uncertainty; United States National Institutes of Health; Woman; Writing; career; cost; design; experience; experimental analysis; graduate student; help-seeking behavior; improved; innovation; laboratory experience; learning materials; men; next generation; research study; statistics; tool; web portal; web site

 DESCRIPTION (provided by applicant): The capacity of laboratory animal research to be translated to interventions for human health is dependent on research reproducibility, replicability, and generalizability (RRG). It is often the case that challenges with RRG arise from differences in scientific protocols, unknown or uncontrolled confounding factors, incomplete communication of scientific protocols, and unintentional misapplication of statistical principles, rather than the oft-discussed research misconduct. Many of these challenges with RRG involve practical and theoretical aspects of statistics and study design that go beyond what is taught in basic statistics courses or textbooks. We therefore propose creating a set of animated vignettes to educate early career, laboratory animal investigators (namely, graduate students, postdoctoral fellows, and beginning investigators) about these issues. We specifically propose modules on variability, power, randomization, hypothesis testing, and inferences that address common, and yet not routine-textbook needs of laboratory researchers. Each module will be composed of several short, animated vignettes that will 1) discuss a statistical or design principle that is important for RRG; 2) foster dialogue and collaboration between statistical and laboratory animal scientists; and 3) model diversity of statistical and laboratory animal scientist with respect to expertise and demographic characteristics. Each vignette will also be evaluated for content validity, face validity, and educational value by consulting with statistical experts, experienced lab animal researchers, and early career investigators, respectively. Finally, vignettes will be reinforced with additional online instructional content, including tutorial literture and self-assessment quizzes. Our team will widely disseminate the instructional materials leveraging our experience and resources creating and sharing online educational content, and we commit to maintain the materials in an openly available web portal without cost to end users. By supporting principles of RRG in this way, we contribute broadly to the mission of the NIH in fostering fundamental creative discoveries, innovative research strategies, and their applications; developing, maintaining, and renewing scientific human resources; and exemplifying and promoting the highest level of scientific integrity in the conduct of science. We specifically contribute to the mission of the NIGMS by "training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacities throughout the country."

 描述（由申请人提供）：实验动物研究转化为人类健康干预措施的能力取决于研究的再现性、可复制性和普遍性（RRG）。 RRG 的挑战通常来自于 科学协议的差异、未知或不受控制的混杂因素、科学协议的不完整沟通以及统计原理的无意误用，而不是经常讨论的研究不当行为。 RRG 面临的许多挑战涉及统计学和研究设计的实践和理论方面，超出了基础统计学课程或教科书所教授的内容。因此，我们建议创建一组动画短片，以教育早期职业、实验动物研究人员（即研究生、博士后研究员和初级研究人员）了解这些问题。我们特别提出了有关变异性、功效、随机化、假设检验和推论的模块，以满足实验室研究人员的常见但非常规教科书需求。每个模块将由几个简短的动画小插图组成，这些小插图将 1) 讨论对 RRG 很重要的统计或设计原理； 2）促进统计和实验动物科学家之间的对话与合作； 3）统计和实验动物科学家在专业知识和人口特征方面的多样性模型。每个小插图还将分别咨询统计专家、经验丰富的实验动物研究人员和早期职业调查人员，评估其内容有效性、表面有效性和教育价值。最后，小插图将通过额外的在线教学内容得到加强，包括教程文献和自我评估测验。我们的团队将利用我们创建和共享在线教育内容的经验和资源来广泛传播教学材料，并且我们承诺在公开可用的门户网站中维护这些材料，而无需最终用户付费。通过以这种方式支持 RRG 的原则，我们为 NIH 促进基本创造性发现、创新研究策略及其应用的使命做出了广泛贡献；开发、维持和更新科学人力资源；体现和促进科学行为中最高水平的科学诚信。我们通过“培训下一代科学家， 增强科学队伍的多样性，并发展全国各地的研究能力。”