Pemphigus & Pemphigoid: from the bench to the bedside

天疱疮

• 批准号: 7996440
• 负责人: SERGEI A GRANDO
• 金额: $ 2万
• 依托单位: INTERNATIONAL PEMPHIGUS PEMPHIGOID FDN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7996440
• 关键词: Address; Algorithms; Area; Autoantibodies; Basic Science; Bulla; Bullous Pemphigoid; Clinical; Clinical Investigator; Clinical Trials; Communities; Consensus; Data; Development; Disease; Foundations; Goals; Human; International; Mediating; Multicenter Trials; Orphan Disease; Pathogenesis; Patients; Pemphigus; Physicians; Public Health; Rare Diseases; Research; Research Personnel; Scientist; Severity of illness; Terminology; Touch sensation; United States National Institutes of Health; Work; bench to bedside; clinical application; clinically relevant; effective therapy; interest; meetings; novel; novel strategies; novel therapeutic intervention; randomized trial; response; skin disorder; symposium

DESCRIPTION (provided by applicant): Pemphigus and pemphigoid are serious blistering diseases of the skin. Rapid advances are being made in understanding the pathogenesis of pemphigus and pemphigoid and developing novel approaches to these diseases. The first and second national conferences on pemphigus were held on the NIH campus in 2001 and 2005 and were very successful. We now propose a third conference -- "Pemphigus & Pemphigoid: from the bench to the bedside". It will be sponsored by the International Pemphigus and Pemphigoid Foundation, and will bring together basic scientists and clinical investigators working on the mechanisms of, and novel therapeutic approaches to, human autoantibody mediated diseases in general and pemphigus and pemphigoid, in particular. The goal will be to identify areas of research opportunity that will most effectively promote our further understanding of the causes and the treatments of pemphigus and pemphigoid, and to cross-hybridize ideas on how to reach these goals among interested researchers. The Specific Aims of this conference are to: 1) highlight recent advances in defining the pathogenesis of pemphigus and pemphigoid; 2) discuss the feasibility of setting up cooperative multinational endeavors, so as to: i) define agreed upon algorithm to treat patients with pemphigus or pemphigoid; and ii) conduct multi-institutional randomized trials; and 3) respond to patient's requests and needs for better information and for more rapid progress in the treatment of these orphan diseases. There will be focused presentations of the clinical trial data in patients with pemphigus and pemphigoid by the leading investigators from all over the world. The scientific presentations will be followed by an extended group discussion of the most urgent, clinically relevant issues that hamper development of safer treatments, and specifically address obstacles to organizing multicenter trials for blistering diseases. We expect the conference will attract 140-160 scientists and clinicians dedicated to investigate and treat pemphigus and pemphigoid.

描述（由申请人提供）：Pemphigus和Pemphigoid是皮肤的严重起泡疾病。在理解Pemphigus和Pemphigoid的发病机理以及为这些疾病开发新的方法时，正在取得快速的进步。 2001年和2005年在NIH校园举行了关于Pemphigus的第一和第二个国家会议，非常成功。现在，我们提出了第三次会议 - “ Pemphigus＆Pemphigoid：从长凳到床边”。它将由国际Pemphigus和Pemphigoid Foundation赞助，并将将基础科学家和临床研究人员汇总为致力于人类自身抗体介导的疾病，尤其是Pemphigus和Pemphigoid的新型治疗方法和新型治疗方法。目的是确定研究机会领域，这些领域将最有效地促进我们对Pemphigus和Pemphigoid的原因和治疗方法的进一步理解，并跨杂交思想，即如何在有兴趣的研究人员中实现这些目标。这次会议的具体目的是：1）突出显示定义Pemphigus和Pemphigoid发病机理的最新进展； 2）讨论建立合作跨国努力的可行性，以便以下内容：i）定义同意的算法以治疗Pemphigus或Pemphigoid的患者； ii）进行多机构的随机试验； 3）响应患者的要求和需求，以便对这些孤儿疾病的治疗方法进行更快的进展。来自世界各地的领先研究人员将重点介绍Pemphigus和Pemphigoid患者的临床试验数据。科学演讲将进行扩展的小组讨论，讨论最紧急，与临床相关的问题，以阻碍开发更安全的治疗方法，并特别解决组织多中心试验的障碍。我们预计会议将吸引140-160名科学家和临床医生，专门研究和治疗Pemphigus和Pemphigoid。