Transport ATPases: From Molecules to Maladies

运输ATP酶：从分子到疾病

• 批准号: 7908312
• 负责人: RAJINI RAO
• 金额: $ 0.75万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908312
• 关键词: ATP phosphohydrolase; Acid-Base Equilibrium; Antineoplastic Agents; Applications Grants; Attention; Biochemistry; Biogenesis; Catalysis; Cations; Cell membrane; Cellular biology; Chemotherapy-Oncologic Procedure; Cholesterol; Collaborations; Communicable Diseases; Computational Biology; Copper; Development; Diabetic ulcer; Disabled Persons; Discipline; Disease; Drug Transport; Drug resistance; Drug usage; Enzymes; Fellowship; Fostering; Future; Gastric ulcer; Genetic Medicine; Goals; Health; Heart Diseases; Heart failure; Hereditary Disease; Human Pathology; Human body; Immune; Ions; Lead; Life; Lipids; Liver; Malignant Neoplasms; Membrane; Mentors; Metabolic; Mitochondrial Diseases; Movement; Multi-Drug Resistance; Names; Nanotechnology; Nerve Degeneration; Occupations; Orphan; Parkinson Disease; Participant; Pharmaceutical Preparations; Pharmacology; Process; Public Health; Pump; Research; Research Personnel; Role; Scientist; Site; Sodium Chloride; Structure; Technology; Trace metal; Treatment Failure; Vesicle; Vision; Water Movements; Work; Writing; hearing impairment; member; metalloenzyme; novel strategies; posters; skin disorder; solute; symposium; trafficking

DESCRIPTION (provided by applicant): The FASEB Summer Conference entitled, "Transport ATPases: From Molecules to Maladies" will bring together approximately 150 investigators from diverse scientific disciplines, including structural and computational biology, genetics and medicine, cell biology, biochemistry and pharmacology, to discuss exciting new developments relating to ion and solute pumps from June 6-11, 2010 at Snowmass Village, CO. The goal of the conference will be the timely integration of different lines of research on this topic for a deep, mechanistic understanding of human pathologies, paving the way for new therapies and advances in nanotechnology. An impetus for the conference is the rapidly growing number of diseases associated with Transport ATPases, among them: cancer and drug resistance, heart disease, immune and infectious diseases, ulcers, diabetes, vision and hearing loss, neurodegeneration and mitochondrial diseases. Sessions will include Rotary Catalysis, Structure and Mechanism of ATPases, Membrane Dynamics and Vesicle Fusion, Orphan ATPases, Transport ATPases and Cancer, Biogenesis, turnover and trafficking of ATPases. All major classes of Transport ATPases (P, V, F and ABC-type) will be covered, ranging in substrate from cations (H+, Na+, K+, Ca2+, Cu+) to hydrophobic drugs, cholesterol and lipids. Several speakers will be junior investigators and a Young Investigator's Forum will include selected talks from poster presentations. There will be two mentoring sessions for junior investigators: Resume building and Job searches, and Writing a Fellowship or Grant application. Special attention will be given to increase diversity among participants and the conference site will be accessible to persons with disabilities. The conference will provide ample opportunities for collegial discussions, stimulate new ideas and collaborations and foster future research on these important enzymes and metabolic engines. This is the only conference that unites scientists working in disparate fields on the sole and common topic of Transport ATPases. Project Narrative Relevance of the Conference to Public Health: Transport ATPases are essential for life and good health. They work as nanomotors or metabolic engines, producing virtually all the ATP used to fuel active processes in the human body. Other members control acid-base balance, salt and water movements within, outside and across cell membranes. Still others control the movement of trace metals, like copper into metalloenzymes. In cancer, chemotherapy often leads to increased activity of drug transporting ATPases, leading to multidrug resistance and failure of treatment. Other transport ATPases are defective in a host of genetic disorders, including a form of Parkinsons, liver and skin disease, vision and hearing loss, to name a few. Some are targets of drugs used to treat heart failure and stomach ulcers. Thus, bringing together researchers who use very different approaches to study Transport ATPases will lead to a better understanding of their role in disease and offer new approaches in treatment and technology.

描述（申请人提供）：FASEB夏季会议，题为“运输ATPases：从分子到疾病”将汇集大约150名来自不同科学学科的研究人员，包括结构和计算生物学、遗传学和医学、细胞生物学、生物化学和药理学，讨论与离子和溶质泵相关的令人兴奋的新发展，6月6日至11日，2010年在斯诺马斯村，公司的会议的目标将是对这个主题的深入，机械的理解，为新的疗法和纳米技术的进步铺平了道路的不同研究线的及时整合。会议的推动力是与转运ATP酶相关的疾病数量迅速增加，其中包括：癌症和耐药性，心脏病，免疫和传染病，溃疡，糖尿病，视力和听力损失，神经变性和线粒体疾病。会议将包括旋转催化，ATP酶的结构和机制，膜动力学和囊泡融合，孤儿ATP酶，运输ATP酶和癌症，生物发生，ATP酶的周转和贩运。所有主要类别的转运ATP酶（P，V，F和ABC型）将被涵盖，从阳离子（H+，Na+，K+，Ca2+，Cu+）到疏水药物，胆固醇和脂质的底物范围。几位发言者将是初级调查员，青年调查员论坛将包括从海报展示中挑选的演讲。将有两个初级调查员辅导会议：简历建设和求职，写奖学金或赠款申请。将特别注意增加与会者的多样性，会议地点将方便残疾人使用。会议将为大学讨论提供充足的机会，激发新的想法和合作，并促进对这些重要酶和代谢引擎的未来研究。这是唯一的会议，团结科学家在不同领域的唯一和共同的主题运输ATP酶工作。 项目叙述 会议与公共卫生的相关性：运输ATP酶对生命和良好健康至关重要。它们作为纳米发动机或代谢引擎工作，产生几乎所有用于为人体活动过程提供燃料的ATP。其他成员控制酸碱平衡，盐和水在细胞膜内外和跨细胞膜的运动。还有一些控制微量金属的运动，如铜进入金属酶。在癌症中，化疗通常导致药物转运ATP酶活性增加，导致多药耐药性和治疗失败。其他转运ATP酶在许多遗传疾病中有缺陷，包括帕金森氏症、肝脏和皮肤病、视力和听力损失等。有些是治疗心力衰竭和胃溃疡的药物的靶点。因此，将使用非常不同方法研究转运ATP酶的研究人员聚集在一起，将有助于更好地了解它们在疾病中的作用，并提供新的治疗方法和技术。