Training Program In Cellular and Molecular Medicine

项目总结/摘要 细胞与分子医学（CMM）培养计划的使命是培养博士生。科学家 在细胞和分子水平上对直接影响理解的主题进行实验室研究， 诊断、治疗和预防人类疾病。通过一系列量身定制的课程， 讨论，个性化的临床暴露和实验室研究，博士该计划的候选人将 接受严格的科学研究培训，全面了解人体生物学和人类 疾病与对转化研究的强调一致，大多数CMM教师在临床环境中工作， 分布在约翰霍普金斯医学院的22个临床和基础科学部门和4个研究所。 医学和公共卫生学院。培训师将接受导师培训并接受严格评估 根据优点，指导能力和程序适合的标准。目前的课程规模为121名教师， 115名学生通过积极的导师招聘，更新和 流动性，以确保最佳的培养环境博士。候选人全面审查接纳20-24名受训人员 从一个强大的池大小约150培训补助金合格的候选人，最近增加了40%， 在基于证据的决定取消GRE之后，代表性不足的少数民族申请人数增加了一倍 要求。培训计划将利用机构资金支付所有年份的学费， 管理和所有计划活动，并保证培训生的支持。第一年的课程将开始与 密集的人体入门课程，结合了动手解剖人体尸体， 虚拟组织学实验室，课堂和电子讲座，以及学生的小组报告。遵循一门基础科学 课程涵盖分子生物学，遗传学，生物化学和细胞生物学的原理，伴随着 三个为期10周的实验室轮换，今年将结束介绍临床研究和细胞， 疾病的分子基础，涵盖了人类的临床和/或社会相关疾病谱 身体，完成一年的循环从“书到板凳到床边”。其他特定于计划的活动将 包括一个赠款写作讲习班，一个新开发的严谨性和再现性研究（3R）课程， 在临床合作指导下的个性化Bench to Bedside and Back（3B）临床体验， 3-4年的导师。该计划赞助了年度务虚会，期刊俱乐部和学生运行的研究， 进步研讨会系列。在教学和非学术轨道上有组织的职业培训机会 （选项）是内置的课程要求和毕业生追求多样化的研究事业，包括 学术教师（20%），工业（31%），医生科学家（19%），政府（6%），商业，政策或作为 博士后入学率很低（5.5%），毕业时间平均为5.7年。总的来说， CMM拥有丰富的经验、资源和人才，可以在研究生教育方面进行创新， 拥有博士学位的员工毕业生经过严格培训，以满足当前和未来的需求。

PROJECT SUMMARY/ABSTRACT The mission of the training program in Cellular and Molecular Medicine (CMM) is to prepare Ph.D. scientists for laboratory research at the cellular and molecular level on topics with a direct impact on the understanding, diagnosis, treatment and prevention of human diseases. Through a series of tailored courses, small group discussions, individualized clinical exposure and laboratory research, Ph.D. candidates of this program will receive a rigorous training in scientific research and a thorough knowledge of human biology and human diseases. Consistent with the emphasis on translational research, most CMM faculty work in clinical settings, distributed over 22 clinical and basic science departments and 4 institutes within the Johns Hopkins School of Medicine and School of Public Health. Trainers will receive mentor training and are rigorously evaluated according to criteria of merit, mentorship ability and program fit. The current program size of 121 faculty and 115 students maintains ~ 1:1 faculty-student ratio by an active process of mentor recruitment, renewal and turnover to ensure the best training environment for Ph.D. candidates. A holistic review admits 20-24 trainees from a robust pool size of ~150 training grant eligible candidates, which recently increased by 40% with a doubling of underrepresented minority applications following an evidence-based decision to remove the GRE requirement. The training program will leverage institutional funds to defray tuition charges in all years, support administration and all program activities and guarantee trainee support. The first year curriculum will begin with the intensive Introduction to Human Body course that combines hands-on dissection of the human cadaver, virtual histology labs, in-class and e-lectures, and group presentations by students. Following a basic science curriculum covering principles in molecular biology, genetics, biochemistry and cell biology, accompanied by three 10-week laboratory rotations, the year will end with Introduction to Clinical Research and Cellular and Molecular Basis of Disease that covers a spectrum of clinically and/or socially relevant disorders of the human body, completing the cycle of the year from "book to bench to bedside". Other program-specific activities will include a Grant Writing workshop, a newly developed Rigor and Reproducibility in Research (3R) course and an individualized Bench to Bedside and Back (3B) clinical experience under the direction of a clinical co- mentor in years 3-4. The program sponsors an Annual Retreat, journal club and student-run research in progress seminar series. Structured career training opportunities in teaching and non-academic tracks (OPTIONS) are built into the curriculum requirements and graduates pursue diverse research careers including academic faculty (20%), industry (31%), physician scientists (19%), government (6%), business, policy or as postdoctoral fellows. Attrition rates are low (5.5%) and time to graduation has averaged 5.7 years. In summary, CMM has the experience, resources and talent to innovate in graduate education and supply the biomedical workforce with Ph.D. graduates rigorously trained to meet current and future needs.