2016 Membrane Transport Proteins: Translating Molecules to Medicine Gordon Research Conference and Seminar

2016年戈登膜转运蛋白研究会议题为"将分子转化为医学" 将为临床相关和高度可药用的研究带来迫切需要的转化重点 膜转运蛋白尽管它们占人类基因组的10%，并对人类基因组的全部功能有贡献， 高度流行（自闭症、糖尿病）以及孤儿和罕见疾病（粘脂沉积症4型，Christianson 综合征），膜转运蛋白作为治疗靶点的潜力在很大程度上仍未开发。九 科学会议是高度跨学科的，汇集了一些不太重要的主题和技术。 传统上相关的：这些包括干细胞技术，3D类器官，化学物质的虚拟开采， 宇宙的抑制剂，和单分子动力学，作为例子。每次演讲后都有充足的讨论时间， 每天的海报会议和下午的自由时间为非正式讨论、建立网络提供了大量的机会。 形成新的合作。一个特别的制药会议将有助于建立行业和 学术界应对药物开发管道中的挑战。主题演讲将以GRC为特色， 亚历山大M. Cruickshank讲座获奖者Nieng Yan博士，其最近的里程碑式的高分辨率结构 的人类葡萄糖转运蛋白已经抓住了这种膜转运蛋白的挑战和机遇， 领域大约150名与会者将来自工业界、学术界、研究机构和 政府和将跨越所有职业水平，从早期的职业调查员（研究生， 博士后研究员）预计将占与会者的50%，职业中期和高级科学家， 教授们。这种组合提供了一个理想的机会，垂直和同行的指导，和网络，必不可少的 这一领域未来的健康和生产力。第一次，我们将举办一个会前毕业生 研究研讨会组织的，并专门为，年轻的研究人员。GRS将包括海报 会议，简短的会谈和职业小组邀请来自制药，学术界和出版界的领导人， 其目标是促进科学和专业发展， 实习生和研究员。组织者致力于促进妇女的多样性和包容性， 少数民族和残疾人。为此，我们的目标是在发言者中实现性别平等（50%）， 讨论领导人，并提高所有代表性不足的群体的可见度。的另一个创新特点， 这次会议，电力小时，是一个论坛，旨在解决妇女在科学面临的挑战。到 为了促进国际影响，与会者选择在美国和美国之间交替举行会议， 和欧洲最近，会议在佛蒙特州举行，2016年的地点是意大利。集团风险管理委员会 提供种子资金，并直接与会议地点谈判费用，以将费用控制在最低限度。 该申请寻求部分资金，以支付受邀演讲者，包括妇女和 少数民族和年轻的调查员。

The 2016 Gordon Research Conference on Membrane Transporters titled “Translating Molecules to Medicine” will bring an urgently needed translational focus to research on clinically relevant and highly druggable membrane transporters. Although they account for 10% of the human genome and contribute to a gamut of highly prevalent (autism, diabetes) as well as orphan and rare diseases (Mucolipidosis type 4, Christianson syndrome), membrane transporters remain largely untapped in their potential as therapeutic targets. The nine scientific sessions are highly interdisciplinary, bringing together topics and techniques that are not conventionally related: these include stem cell technology, 3D organoids, virtual mining of the chemical universe for inhibitors, and single molecule dynamics, as examples. Ample discussion time after each talk, daily poster sessions and afternoon free time allow plenty of opportunity for informal discussion, networking and forming new collaborations. A special Pharma session will help build consortia between industry and academics to tackle challenges in the drug development pipeline. The Keynote session will feature the GRC Alexander M. Cruickshank Lecture awardee, Dr. Nieng Yan, whose recent landmark high-resolution structures of human glucose transporters have captured the challenges and opportunities of this membrane transporter field. Approximately 150 participants will be drawn from industry, academia, research institutions and government and will span all career levels, ranging from early career investigators (graduate students, postdoctoral fellows) projected to comprise 50% of attendees, to mid-career and senior scientists and professors. This mix offers an ideal opportunity for vertical and peer mentoring, and networking, essential for the future health and productivity of this field. For the first time, we will host a pre-conference Graduate Research Seminar organized by, and exclusively for, young investigators. The GRS will include poster sessions, short talks and a Careers Panel with invited leaders from pharma, academia and publishing sectors, with a goal of fostering scientific and professional development and instilling confidence and leadership skills in student trainees and fellows. The organizers are committed to promote diversity and inclusion of women, minorities and persons of disability. To this end, our goal is to achieve gender parity (50%) in speakers and discussion leaders, and to increase the visibility of all underrepresented groups. Another innovative feature of this conference, the Power Hour, is a forum designed to address challenges that women face in science. To foster international reach, participants have elected to alternate the location of the conference between the US and Europe. Most recently, the conference was held in Vermont, and in 2016 the venue is Italy. The GRC provides seed money and negotiates costs directly with the conference site, to keep expenses at a minimum. This application seeks partial funding to cover registration costs for invited speakers, including women and minorities, and young investigators.